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Results for "

cot

" in MedChemExpress (MCE) Product Catalog:

5

Inhibitors & Agonists

1

Biochemical Assay Reagents

2

Recombinant Proteins

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-32018
    Cot inhibitor-2
    3 Publications Verification

    		 MAP3K Cancer
    Cot inhibitor-2 is a potent, selective and orally active cot (Tpl2/MAP3K8) inhibitor with an IC50 of 1.6 nM. Cot inhibitor-2 inhibts TNF-α production in LPS-stimulated human whole blood with an IC50 of 0.3 μM .
    Cot inhibitor-2
  • HY-32015
    Cot inhibitor-1
    2 Publications Verification

    		 MAP3K Inflammation/Immunology
    Cot inhibitor-1 (compound 28) is a selective tumor progression loci-2 (Tpl2) kinase inhibitor with an IC50 of 28 nM. Cot inhibitor-1 shows an inhibition of TNF-alpha production in human whole blood with an IC50 of 5.7 nM .
    Cot inhibitor-1
  • HY-12358
    Tpl2 Kinase Inhibitor 1
    1 Publications Verification

    		 MAP3K p38 MAPK MAPKAPK2 (MK2) Inflammation/Immunology Cancer
    Tpl2 Kinase Inhibitor 1 is a 3-pyridylmethylamino analog, and is a selective Tpl2 inhibitor (IC50=50 nM). Tpl2 consists of COT kinase and MAP3K8. Tpl2 Kinase Inhibitor 1 plays an important role in the regulation of the inflammatory response and the progression of some cancers .
    Tpl2 Kinase Inhibitor 1
  • HY-124953
    7,3',4'-Trihydroxyisoflavone

    		MAP3K Apoptosis Cancer
    7,3',4'-Trihydroxyisoflavone, a major metabolite of Daidzein, is an ATP-competitive inhibitor of Cot (Tpl2/MAP3K8) and MKK4. 7,3',4'-Trihydroxyisoflavone has anticancer, anti-angiogenic, chemoprotective, and free radical scavenging activities .
    7,3',4'-Trihydroxyisoflavone
  • HY-169153
    Cot inhibitor-3

    		Others Inflammation/Immunology
    Cot inhibitor-3 (Compound 33) is a potent and selective cancer osaka thyroid (COT) kinase inhibitor, with an IC50 of 4 nM. Cot inhibitor-3 can be used to prevent inflammation-driven lameness .
    Cot inhibitor-3

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