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Results for "

digoxin

" in MedChemExpress (MCE) Product Catalog:

7

Inhibitors & Agonists

2

Biochemical Assay Reagents

1

Natural
Products

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-158292
    Digoxin-OVA

    		Endogenous Metabolite Na+/K+ ATPase Inflammation/Immunology
    Digoxin-OVA is a biochemical reagent that can be used as a biological material or organic compound for life science related research .
    Digoxin-OVA
  • HY-119101
    AZD-5672
    1 Publications Verification

    		 CCR Potassium Channel P-glycoprotein Inflammation/Immunology
    AZD-5672 is an orally active, potent, and selective CCR5 antagonist (IC50=0.32 nM). AZD-5672 shows moderate activity against the hERG ion channel (binding IC50=7.3 μM). AZD5672 is a substrate of human P-gp, and inhibits P-gp-mediated digoxin transport (IC50=32 μM). AZD-5672 can be used for the research of rheumatoid arthritis .
    AZD-5672
  • HY-145154
    Digoxigenin monodigitoxoside

    		Na+/K+ ATPase Metabolic Disease
    Digoxigenin monodigitoxoside is a Na+/K+ ATPase inhibitor and cardiac glycoside metabolite of digoxin.
    Digoxigenin monodigitoxoside
  • HY-161533
    Digoxin/BSA

    		Biochemical Assay Reagents Inflammation/Immunology
    Digoxin/BSA is an antigen-adjuvant conjugate of Digoxin (HY-B1049) and Bovine Serum Albumin (BSA). By conjugating the antigen with a protein adjuvant, the production of antigen-specific antibodies in vaccine models can be enhanced. The conjugate does not affect protein folding or disrupt major epitopes, and it can enhance cross-presentation and the generation of antigen-specific T cells.
    Digoxin/BSA
  • HY-125337
    SC4453

    		Na+/K+ ATPase Cardiovascular Disease
    SC4453 is a digoxin analogue in which the lactone ring at C17β is replaced by a pyrazine ring. SC4453 is slightly inferior to digoxin in inhibiting (Na+ + K+)-ATPase, but shows similar sensitivity to potassium ions. The differences in the sensitivity of SC4453 to heart and brain tissue from different species are mainly due to differences in its dissociation rate from the receptor. These observations confirm the high sensitivity of the human heart to cardiac glycosides.
    SC4453
  • HY-15718B
    Istaroxime oxalate

    PST2744 oxalate

    		 Na+/K+ ATPase Cardiovascular Disease
    Istaroxime oxalate (PST2744 oxalate) is the oxalate form of Istaroxime (HY-15718). Istaroxime oxalate is is an inotropic agent, that inhibits Na +/K +-ATPase with an IC50 of 0.11 μM. Istaroxime oxalate increases force of contraction in guinea pig atria and twitch amplitude in isolated guinea pig myocytes without causing lethal arrhythmias .
    Istaroxime oxalate
  • HY-136677
    Lnd 796

    		Others Cardiovascular Disease
    LND 796 is an aminosteroidal derivative with positive inotropic effects similar to those of digitalis. It exhibits electrophysiological, toxic, and inotropic effects in normal and partially potassium-depolarized ventricular muscles. LND 796 requires higher concentrations than digoxin to induce the same toxic symptoms. It exhibits a concentration-dependent positive inotropic effect on guinea pig papillary muscles in normal potassium solution. In partially potassium-depolarized papillary muscles, LND 796 enhances both components of contraction and increases the amplitude of slow action potentials. The mechanism of positive inotropic action of LND 796 involves enhanced calcium entry in calcium channels and inhibition of sodium-potassium ATPase. Due to its expanded positive inotropic range, LND 796 may have potential application in the treatment of congestive heart failure.
    Lnd 796

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