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Results for "

epoxidase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (2) Akt (1) Antibiotic (9) Bacterial (7) COX (2) Fungal (11) Isotope-Labeled Compounds (3) Photosystem II (2) PI3K (1) PTEN (1) Transthyretin (TTR) (2)
By Research Areas:	Cancer (2) Infection (11) Inflammation/Immunology (2) Metabolic Disease (9)

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Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0348

Liranaftate Piritetrate; M-732	Fungal	Infection
Liranaftate (Piritetrate) is a squalene epoxidase inhibitor with anti-fungicidal activities. Liranaftate can be used for the research of dermatophytes. Liranaftate also suppresses fungal element-promoted production of IL-8 and experimental inflammation .

HY-160093

SQLE-IN-1	PTEN Akt PI3K	Metabolic Disease
SQLE-IN-1 (compound 19) is a *squalene epoxidase* (SQLE) inhibitor. SQLE-IN-1 inhibits the proliferation and migration of Huh7 cells. SQLE-IN-1 inhibits the cell cholesterol generation. SQLE-IN-1 increases the expression of PTEN and inhibits PI3K and AKT** .

HY-17395

Terbinafine hydrochloride 5+ Cited Publications TDT 067 hydrochloride	Fungal Bacterial Antibiotic	Infection
Terbinafine hydrochloride (TDT 067 hydrochloride) is an orally active and potent antifungal agent. Terbinafine hydrochloride is a potent non-competitive inhibitor of squalene epoxidase from Candida, with a K_i of 30 nM. Terbinafine hydrochloride also shows antibacterial activity against certain Gram-positive and Gram-negative bacteria . Terbinafine hydrochloride is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-17395A

Terbinafine 5+ Cited Publications TDT 067	Fungal Bacterial Antibiotic	Infection
Terbinafine (TDT 067) is an orally active and potent antifungal agent. Terbinafine is a potent non-competitive inhibitor of squalene epoxidase from Candida, with a K_i of 30 nM. Terbinafine also shows antibacterial activity against certain Gram-positive and Gram-negative bacteria . Terbinafine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-100303A

FR194738 2 Publications Verification	Others	Metabolic Disease
FR194738 is a squalene epoxidase inhibitor. FR194738 inhibits squalene epoxidase activity in HepG2 cell homogenates with an IC₅₀ of 9.8 nM.

HY-N9777

Procyanidin B-5 3,3'-di-O-gallate	Others	Metabolic Disease
Procyanidin B-5 3,3'-di-O-gallate is a potent inhibitor of squalene epoxidase with an IC₅₀ of 0.55 μM. Procyanidin B-5 3,3'-di-O-gallate reduces cholesterol by inhibiting squalene epoxidase activity .

HY-B0348R

Liranaftate (Standard)	Fungal	Infection
Liranaftate (Standard) is the analytical standard of Liranaftate. This product is intended for research and analytical applications. Liranaftate (Piritetrate) is a squalene epoxidase inhibitor with anti-fungicidal activities. Liranaftate can be used for the research of dermatophytes. Liranaftate also suppresses fungal element-promoted production of IL-8 and experimental inflammation .

HY-17395B

Terbinafine lactate TDT 067 lactate	Antibiotic Fungal Bacterial	Infection
Terbinafine lactate (TDT 067 lactate) is an orally active and potent antifungal agent. Terbinafine lactate is a potent non-competitive inhibitor of squalene epoxidase from Candida, with a K_i of 30 nM. Terbinafine lactate also shows antibacterial activity against certain Gram-positive and Gram-negative bacteria . Terbinafine (lactate) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-17395AR

Terbinafine (Standard)	Fungal Bacterial Antibiotic	Infection
Terbinafine (Standard) is the analytical standard of Terbinafine. This product is intended for research and analytical applications. Terbinafine (TDT 067) is an orally active and potent antifungal agent. Terbinafine is a potent non-competitive inhibitor of squalene epoxidase from Candida, with a K_i of 30 nM. Terbinafine also shows antibacterial activity against certain Gram-positive and Gram-negative bacteria . Terbinafine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-17395R

Terbinafine hydrochloride (Standard)	Fungal Bacterial Antibiotic	Infection
Terbinafine hydrochloride (Standard) is the analytical standard of Terbinafine hydrochloride. This product is intended for research and analytical applications. Terbinafine hydrochloride (TDT 067 hydrochloride) is an orally active and potent antifungal agent. Terbinafine hydrochloride is a potent non-competitive inhibitor of squalene epoxidase from Candida, with a K_i of 30 nM. Terbinafine hydrochloride also shows antibacterial activity against certain Gram-positive and Gram-negative bacteria . Terbinafine hydrochloride is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-100303

FR194738 free base 2 Publications Verification	Others	Metabolic Disease
FR194738 free base is a squalene epoxidase inhibitor. FR194738 inhibits squalene epoxidase activity in HepG2 cell homogenates with an IC₅₀ of 9.8 nM.

HY-17396

Butenafine Hydrochloride 1 Publications Verification KP363 Hydrochloride	Fungal Antibiotic	Infection
Butenafine Hydrochloride (KP363 Hydrochloride) is a synthetic benzylamine antifungal, works by inhibiting the synthesis of sterols by inhibiting squalene epoxidase.

HY-17396S

Butenafine-13C,d3 hydrochloride KP363-¹³C,d₃ hydrochloride	Isotope-Labeled Compounds Fungal Antibiotic	Infection
Butenafine- ¹³C,d₃ (hydrochloride) is the ¹³C- and deuterium labeled. Butenafine Hydrochloride (KP363 Hydrochloride) is a synthetic benzylamine antifungal, works by inhibiting the synthesis of sterols by inhibiting squalene epoxidase.

HY-N9625

Violaxanthin	Photosystem II	Others
Violaxanthin is a carotenoid which can be biosynthesized from zeaxanthin with zeaxanthin epoxidase (ZEP) by way of antheraxanthin only in photosynthetic eukaryotes including higher plants and involved in the xanthophyll cycle to eliminate excessive light energy .

HY-N12970

14S(15R)-EET	Others	Others
14S(15R)-EET is an endogenous epoxytrienoic acid derivative that mainly exists in rat organs. By studying its metabolic process, it was found that its stereoselective hydration and formation of chiral diols were significantly affected by epoxidase. Different 14,15-EET enantiomers showed different regions and stereochemistry of hydration reactions, among which 14(R),15(S)-EET showed specific hydration for C15. These findings reveal the important role of epoxidase in the metabolism of endogenous EETs, and the differences in enzyme affinity and reaction rate for individual EET enantiomers may lead to their stereoselective metabolism .

HY-16343C

NB-598 Maleate Maximum Cited Publications 12 Publications Verification	Others	Metabolic Disease
NB-598 Maleate is a potent and competitive inhibitor of *squalene epoxidase* (SE)**, and suppresses triglyceride biosynthesis through the farnesol pathway. NB-598 (Maleate) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-16343

NB-598 Maximum Cited Publications 12 Publications Verification	Others	Metabolic Disease
NB-598 is a potent and competitive inhibitor of *squalene epoxidase* (SE)**, and suppresses triglyceride biosynthesis through the farnesol pathway. NB-598 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-16343A

NB-598 hydrochloride	Others	Metabolic Disease
NB-598 hydrochloride is a potent and competitive inhibitor of *squalene epoxidase* (SE)**, and suppresses triglyceride biosynthesis through the farnesol pathway. NB-598 (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-N9625R

Violaxanthin (Standard)	Photosystem II	Others
Violaxanthin (Standard) is the analytical standard of Violaxanthin. This product is intended for research and analytical applications. Violaxanthin is a carotenoid which can be biosynthesized from zeaxanthin with zeaxanthin epoxidase (ZEP) by way of antheraxanthin only in photosynthetic eukaryotes including higher plants and involved in the xanthophyll cycle to eliminate excessive light energy .

HY-17395S

Terbinafine-d3 hydrochloride TDT 067-d₃ hydrochloride	Isotope-Labeled Compounds Fungal Bacterial Antibiotic	Infection
Terbinafine-d₃ (hydrochloride) is the deuterium labeled Terbinafine hydrochloride. Terbinafine hydrochloride (TDT 067 hydrochloride) is an antifungal medication used to treat fungal infections. It is a potent non-competitive inhibitor of squalene epoxidase from Candida with a Ki of 30 nM[1][2]. Terbinafine hydrochloride also antibacterial activity against certain Gram-positive and Gram-negative bacteria[3].

HY-17395AS

Terbinafine-d7 TDT 067-d₇	Isotope-Labeled Compounds Fungal Bacterial Antibiotic	Infection
Terbinafine-d₇ is the deuterium labeled Terbinafine. Terbinafine (TDT 067) is an antifungal medication used to treat fungal infections. It is a potent non-competitive inhibitor of squalene epoxidase from Candida with a Ki of 30 nM[1][2]. Terbinafine also antibacterial activity against certain Gram-positive and Gram-negative bacteria[3].

HY-N12962

11S(12R)-EET	Others	Others
11S(12R)-EET is a dominant enantiomer of epoxytrienoic acid (EET) that is metabolized at a higher rate in rat organs. It shows enantiomeric-dependent reaction selectivity in hydration, especially in the case of 11,12-EET, where water addition is non-regioselective, while in 8,9-EET, water addition occurs mainly at the C9 position. In addition, 11S(12R)-EET generates diol products with specific stereochemistry through enzymatic hydration reactions, which are affected by the selective recognition of epoxidases, reaction conversion rates, and substrate binding parameters .

HY-N1957

Gamma-Mangostin 1 Publications Verification γ-Mangostin	5-HT Receptor COX Transthyretin (TTR)	Metabolic Disease Inflammation/Immunology Cancer
Gamma-Mangostin is a novel competitive 5-hydroxytryptamine 2A (5-HT2A) receptor antagonist and potent epoxidase 2 (COX-2) inhibitor, as well as a transthyroxin protein (TTR) profibrosis inhibitor. Gamma-Mangostin binds to the thyroxine (T4)-binding sites and stabilized the TTR tetramer . Gamma-Mangostin inhibits [3 ^H] spiperone binding to cultured rat aortic myocytes (IC₅₀=3.5 nM) and reduces The perfusion pressure response of rat coronary artery to 5-HT2A (IC₅₀=0.32 μM). Gamma-Mangostin has anti-inflammatory, antibacterial, antioxidant and anticancer activities, and can be used in the study of metabolic disorders such as diabetes .

HY-N1957R

Gamma-Mangostin (Standard)	5-HT Receptor COX Transthyretin (TTR)	Metabolic Disease Inflammation/Immunology Cancer
Gamma-Mangostin (Standard) is the analytical standard of Gamma-Mangostin. This product is intended for research and analytical applications. Gamma-Mangostin is a novel competitive 5-hydroxytryptamine 2A (5-HT2A) receptor antagonist and potent epoxidase 2 (COX-2) inhibitor, as well as a transthyroxin protein (TTR) profibrosis inhibitor. Gamma-Mangostin binds to the thyroxine (T4)-binding sites and stabilized the TTR tetramer . Gamma-Mangostin inhibits [3H] spiperone binding to cultured rat aortic myocytes (IC₅₀=3.5 nM) and reduces The perfusion pressure response of rat coronary artery to 5-HT2A (IC₅₀=0.32 μM). Gamma-Mangostin has anti-inflammatory, antibacterial, antioxidant and anticancer activities, and can be used in the study of metabolic disorders such as diabetes .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N1957

Gamma-Mangostin 1 Publications Verification γ-Mangostin	Structural Classification Xanthones Classification of Application Fields Guttiferae Phenols Polyphenols Garcinia mangostana Linn. Metabolic Disease Plants Disease Research Fields	5-HT Receptor COX Transthyretin (TTR)
Gamma-Mangostin is a novel competitive 5-hydroxytryptamine 2A (5-HT2A) receptor antagonist and potent epoxidase 2 (COX-2) inhibitor, as well as a transthyroxin protein (TTR) profibrosis inhibitor. Gamma-Mangostin binds to the thyroxine (T4)-binding sites and stabilized the TTR tetramer . Gamma-Mangostin inhibits [3 ^H] spiperone binding to cultured rat aortic myocytes (IC₅₀=3.5 nM) and reduces The perfusion pressure response of rat coronary artery to 5-HT2A (IC₅₀=0.32 μM). Gamma-Mangostin has anti-inflammatory, antibacterial, antioxidant and anticancer activities, and can be used in the study of metabolic disorders such as diabetes .

HY-N9777

Procyanidin B-5 3,3'-di-O-gallate	Structural Classification Rheum palmatum L. Polygonaceae Source classification Phenols Polyphenols Plants	Others
Procyanidin B-5 3,3'-di-O-gallate is a potent inhibitor of squalene epoxidase with an IC₅₀ of 0.55 μM. Procyanidin B-5 3,3'-di-O-gallate reduces cholesterol by inhibiting squalene epoxidase activity .

HY-N9625

Violaxanthin	Structural Classification Natural Products Microorganisms Viola tricolor L. Source classification Violaceae Plants	Photosystem II
Violaxanthin is a carotenoid which can be biosynthesized from zeaxanthin with zeaxanthin epoxidase (ZEP) by way of antheraxanthin only in photosynthetic eukaryotes including higher plants and involved in the xanthophyll cycle to eliminate excessive light energy .

HY-N12970

14S(15R)-EET	Structural Classification Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Others
14S(15R)-EET is an endogenous epoxytrienoic acid derivative that mainly exists in rat organs. By studying its metabolic process, it was found that its stereoselective hydration and formation of chiral diols were significantly affected by epoxidase. Different 14,15-EET enantiomers showed different regions and stereochemistry of hydration reactions, among which 14(R),15(S)-EET showed specific hydration for C15. These findings reveal the important role of epoxidase in the metabolism of endogenous EETs, and the differences in enzyme affinity and reaction rate for individual EET enantiomers may lead to their stereoselective metabolism .

HY-N9625R

Violaxanthin (Standard)	Structural Classification Natural Products Microorganisms Viola tricolor L. Source classification Violaceae Plants	Photosystem II
Violaxanthin (Standard) is the analytical standard of Violaxanthin. This product is intended for research and analytical applications. Violaxanthin is a carotenoid which can be biosynthesized from zeaxanthin with zeaxanthin epoxidase (ZEP) by way of antheraxanthin only in photosynthetic eukaryotes including higher plants and involved in the xanthophyll cycle to eliminate excessive light energy .

HY-N12962

11S(12R)-EET	Structural Classification Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Others
11S(12R)-EET is a dominant enantiomer of epoxytrienoic acid (EET) that is metabolized at a higher rate in rat organs. It shows enantiomeric-dependent reaction selectivity in hydration, especially in the case of 11,12-EET, where water addition is non-regioselective, while in 8,9-EET, water addition occurs mainly at the C9 position. In addition, 11S(12R)-EET generates diol products with specific stereochemistry through enzymatic hydration reactions, which are affected by the selective recognition of epoxidases, reaction conversion rates, and substrate binding parameters .

HY-N1957R

Gamma-Mangostin (Standard)	Structural Classification Xanthones Guttiferae Phenols Polyphenols Garcinia mangostana Linn. Plants	5-HT Receptor COX Transthyretin (TTR)
Gamma-Mangostin (Standard) is the analytical standard of Gamma-Mangostin. This product is intended for research and analytical applications. Gamma-Mangostin is a novel competitive 5-hydroxytryptamine 2A (5-HT2A) receptor antagonist and potent epoxidase 2 (COX-2) inhibitor, as well as a transthyroxin protein (TTR) profibrosis inhibitor. Gamma-Mangostin binds to the thyroxine (T4)-binding sites and stabilized the TTR tetramer . Gamma-Mangostin inhibits [3H] spiperone binding to cultured rat aortic myocytes (IC₅₀=3.5 nM) and reduces The perfusion pressure response of rat coronary artery to 5-HT2A (IC₅₀=0.32 μM). Gamma-Mangostin has anti-inflammatory, antibacterial, antioxidant and anticancer activities, and can be used in the study of metabolic disorders such as diabetes .

Cat. No.	Compare	Product Name	Species	Source

HY-P703507

	*Halohydrin epoxidase* A Protein, Tistrella mobilis (His)** Tistrella mobilis (strain KA081020-065)	Others	E. coli
	Halohydrin epoxidase A Protein, Tistrella mobilis (His) is the recombinant Halohydrin epoxidase A, expressed by E. coli , with His labeled tag. The total length of Halohydrin epoxidase A Protein, Tistrella mobilis (His) is 248 a.a., .

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Cat. No.	Product Name	Chemical Structure

HY-17395S

Terbinafine-d3 hydrochloride
Terbinafine-d₃ (hydrochloride) is the deuterium labeled Terbinafine hydrochloride. Terbinafine hydrochloride (TDT 067 hydrochloride) is an antifungal medication used to treat fungal infections. It is a potent non-competitive inhibitor of squalene epoxidase from Candida with a Ki of 30 nM[1][2]. Terbinafine hydrochloride also antibacterial activity against certain Gram-positive and Gram-negative bacteria[3].

Terbinafine-d3 hydrochloride

Terbinafine-d₃ (hydrochloride) is the deuterium labeled Terbinafine hydrochloride. Terbinafine hydrochloride (TDT 067 hydrochloride) is an antifungal medication used to treat fungal infections. It is a potent non-competitive inhibitor of squalene epoxidase from Candida with a Ki of 30 nM[1][2]. Terbinafine hydrochloride also antibacterial activity against certain Gram-positive and Gram-negative bacteria[3].

HY-17396S

Butenafine-13C,d3 hydrochloride
Butenafine- ¹³C,d₃ (hydrochloride) is the ¹³C- and deuterium labeled. Butenafine Hydrochloride (KP363 Hydrochloride) is a synthetic benzylamine antifungal, works by inhibiting the synthesis of sterols by inhibiting squalene epoxidase.

HY-17395AS

Terbinafine-d7
Terbinafine-d₇ is the deuterium labeled Terbinafine. Terbinafine (TDT 067) is an antifungal medication used to treat fungal infections. It is a potent non-competitive inhibitor of squalene epoxidase from Candida with a Ki of 30 nM[1][2]. Terbinafine also antibacterial activity against certain Gram-positive and Gram-negative bacteria[3].

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