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hCAIX-IN-23

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-168030
    hCAIX-IN-23

    		Apoptosis Ferroptosis Carbonic Anhydrase Reactive Oxygen Species Caspase Mitochondrial Metabolism Cancer
    hCAIX-IN-23 (Compound 27) is a human carbonic anhydrase (hCA) inhibitor with Ki values of 10.4 and 8.5 nM for hCA IX and hCA XII, respectively. In addition to inhibiting hCA activity, hCAIX-IN-23 releases NO, exhibiting dual antitumor activity. hCAIX-IN-23 induces apoptosis by regulating mitochondrial caspase activity and the ferroptosis pathway (ferroptosis) through the downregulation of hCA IX and iron-regulatory protein expression. hCAIX-IN-23 is useful for renal cancer research .
    hCAIX-IN-23

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