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hCES2A-IN-2

" in MedChemExpress (MCE) Product Catalog:
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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-155181
    hCES2-IN-1

    		Others Cancer
    hCES2-IN-1 (Compound 24) is a reversible and selective hCES2 inhibitor (IC50: 6.72 μM). hCES2-IN-1 reduces the level of hCES2 in living cells. hCES2-IN-1 is effective against Irinotecan (HY-16562)-induced delayed diarrhea and DSS-induced ulcerative colitis .
    hCES2-IN-1
  • HY-173267
    hCES2A-IN-2

    		Carboxylesterase (CES) Metabolic Disease Cancer
    hCES2A-IN-2 (compound 14n) is an orally active, highly specific, irreversible and covalent hCES2A inhibitor with an IC50 of 0.04 nM. hCES2A-IN-2 covalently binds to hCES2A by specifically targeting the catalytic serine residue (Ser-228). hCES2A-IN-2 can significantly ameliorate Irinotecan-triggered gut toxicity (ITGT) without diminishing the anti-tumor effects of Irinotecan (HY-16562) in tumor-bearing mice .
    hCES2A-IN-2
  • HY-155228
    LK-44

    		Others Inflammation/Immunology
    hCES2A-IN-2 (Compound 44) is an orally active human carboxylesterase 2 (hCES2A) inhibitor (IC50: 5.02 μM). hCES2A-IN-2 improves Irinotecan (HY-16562)-induced delayed diarrhea .
    LK-44
  • HY-155755
    hCES2A-IN-1

    		Carboxylesterase (CES) Drug Derivative Cancer
    hCES2A-IN-1 (compound 20w) is a potent hCES2A inhibitor, with an IC50 value of 1.6 nM. hCES2A-IN-1, a bysspectin A derivative, shows an approximately 1000-fold improvement over the lead compound bysspectin A .
    hCES2A-IN-1
  • HY-147915
    Benz-AP

    		Carboxylesterase (CES) Reactive Oxygen Species Cancer
    Benz-AP is a potent photosensitizer. Benz-AP produces singlet oxygen, with a negative correlation with hCES2 (Human carboxylesterase 2) activity. Benz-AP displays a higher photocytotoxicity potency in cancer cells under low hCES2 environments. Upon TPE (Two-photon excitation), Benz-AP produces ROS and kills cancer cells and tumor spheroids .
    Benz-AP

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