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Results for "

human GPR35

" in MedChemExpress (MCE) Product Catalog:

8

Inhibitors & Agonists

1

Oligonucleotides

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-107539
    GPR35 agonist 4

    		GPR35 Others
    GPR35 agonist 4 (compound 10) is a potent GPR35 agonist with an pEC50 of 5.86. GPR35 agonist 4 shows high potency human and rat GPR35. Mutation of arginine 3.36 eliminates agonist function of GPR35 agonist 4 .
    GPR35 agonist 4
  • HY-107536
    ML 145
    1 Publications Verification

    		 GPR35 CXCR Inflammation/Immunology Endocrinology
    ML 145 is a selective and competitive human GPR35/CXCR8 antagonist with an IC50/EC50 of 20.1 nM. ML 145 has over 1000-fold more selective for GPR35 compared to GPR55 (IC50/EC50=21.7 μM) . ML 145 has no significant activity for GPR35 at either rodent ortholog .
    ML 145
  • HY-B1816
    Zaprinast
    1 Publications Verification

    M&B 22948

    		 Phosphodiesterase (PDE) GPR35 Cardiovascular Disease Neurological Disease Endocrinology
    Zaprinast (M&B 22948) is a selective inhibitor of cGMP-selective Phosphodiesterase (PDE5). Zaprinast causes a significant increase in cGMP levels in myocytes. Zaprinast is a G protein-coupled receptor 35 (GPR35) agonist which activates rat GPR35 strongly and activates human GPR35 moderately. Zaprinast reduces vessel remodeling through antiproliferative and proapoptotic effects .
    Zaprinast
  • HY-RS05705
    GPR35 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    GPR35 Human Pre-designed siRNA Set A contains three designed siRNAs for GPR35 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    GPR35 Human Pre-designed siRNA Set A
    GPR35 Human Pre-designed siRNA Set A
  • HY-169302
    GPR35 activator-1

    		GPR35 Cancer
    GPR35 activator-1 (example 5) is a potent GPR35 activator with a Ki of 0.08 nM for human GPR35 .
    GPR35 activator-1
  • HY-169301
    Gpr35 modulator 1

    		GPR35 Cancer
    Gpr35 modulator 1 (compound 1-18) is a potent modulator of Gpr35, with the IC50 of ≤ 100 nM in HEK293 cells stably transfected with human GPR35 .
    Gpr35 modulator 1
  • HY-106481
    Bufrolin

    		GPR35 Histamine Receptor Inflammation/Immunology
    Bufrolin is a Cromoglycate (histamine release inhibitor) analog and a high potency agonist of GPR35. Bufrolin promotes interactions between β-arrestin-2 and either human GPR35a or rat GPR35. Bufrolin also serves as antiallergic mast cell stabilizer and inhibit an anti-inflammatory response inducible by the internalization peptide. Bufrolin acts as an anti-inflammatory agent to be used in research of delivering pharmacol linked with internalization peptide .
    Bufrolin
  • HY-167706
    Diethyl-Lodoxamide

    		Others Inflammation/Immunology
    Diethyl-Lodoxamide is a highly potent GPR35 agonist with potential to inhibit inflammatory bowel disease. Diethyl-Lodoxamide activates GPR35 in humans, mice and rats, showing similar EC50 values. Diethyl-Lodoxamide can alleviate the clinical symptoms of DSS-induced inflammatory bowel disease in mouse models, and the effect is better than the traditional drug 5-ASA. The pharmaceutical properties of Diethyl-Lodoxamide have been optimized to better meet the requirements of drug design .
    Diethyl-Lodoxamide

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