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immunosuppressant agent

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Cytotoxin (5) Antifolate (9) Apoptosis (8) Autophagy (2) Bacterial (7) CD3 (1) Cytochrome P450 (2) Deubiquitinase (2) Dihydrofolate reductase (DHFR) (2) DNA Alkylator/Crosslinker (4) DNA Methyltransferase (2) DNA/RNA Synthesis (6) Drug Metabolite (3) Endogenous Metabolite (9) Fungal (2) Glucocorticoid Receptor (8) Interleukin Related (1) Isotope-Labeled Compounds (5) Nuclear Factor of activated T Cells (NFAT) (2) Parasite (2) SARS-CoV (2)
By Research Areas:	Cancer (19) Endocrinology (8) Infection (5) Inflammation/Immunology (27) Metabolic Disease (1)

By Targets:

ADC Cytotoxin (5)

Antifolate (9)

Apoptosis (8)

Autophagy (2)

Bacterial (7)

CD3 (1)

Cytochrome P450 (2)

Deubiquitinase (2)

Dihydrofolate reductase (DHFR) (2)

DNA Alkylator/Crosslinker (4)

DNA Methyltransferase (2)

DNA/RNA Synthesis (6)

Drug Metabolite (3)

Endogenous Metabolite (9)

Fungal (2)

Glucocorticoid Receptor (8)

Interleukin Related (1)

Isotope-Labeled Compounds (5)

Nuclear Factor of activated T Cells (NFAT) (2)

Parasite (2)

SARS-CoV (2)

By Research Areas:

Cancer (19)

Endocrinology (8)

Infection (5)

Inflammation/Immunology (27)

Metabolic Disease (1)

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P99152

Muromonab	CD3	Inflammation/Immunology Cancer
Muromonab is a monoclonal antibody targeting the CD3 receptor. Muromonab can block all cytotoxic T cell function. Muromonab also as an immunosuppressant agent given to reduce acute solid organ transplant rejection .

HY-17420

Cyclophosphamide 25+ Cited Publications	DNA Alkylator/Crosslinker	Cancer
Cyclophosphamide is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic activity, a immunosuppressant.

HY-A0133

Chlorphenesin	Bacterial Fungal	Inflammation/Immunology Cancer
Chlorphenesin is a reversible antigen-associated immunosuppressant. Chlorphenesin is an antibacterial and antifungal agent used in numerous eye care cosmetics .

HY-W019721

Cyclosporin D	Nuclear Factor of activated T Cells (NFAT)	Inflammation/Immunology
Cyclosporin D, a metabolite of Cyclosporin A, is a weak immunosuppressant. Cyclosporin D is used as internal standard for quantification of Cyclosporin A . Cyclosporin A is a potent immunosuppressant agent, suppress T cell activation by inhibiting calcineurin and the calcineurin-dependent transcription factors nuclear factor of activated T cells (NFAc) .

HY-122402

Umirolimus	Bacterial	Inflammation/Immunology
Umirolimus, a macrocyclic triene lactone Rapamycin derivative, is powerful immunosuppressant and anti-inflammatory agent. Umirolimus has highly lipophilicity and can be used agent-eluting stent (DES) applications .

HY-150581

CYP3A4-IN-3	Cytochrome P450	Infection Inflammation/Immunology
CYP3A4-IN-3 is a high-affinity specific inhibitor of cytochrome P450 3A4 (CYP3A4) with the IC₅₀ value of 0.075 μM. CYP3A4-IN-3 is a ritonavir analogue, but with a simpler structure and twice the inhibitory effect of ritonavir. CYP3A4-IN-3 is used as an antiviral agent and immunosuppressant .

HY-150580

CYP3A4-IN-2	Cytochrome P450	Inflammation/Immunology Cancer
CYP3A4-IN-2 is a specific inhibitor of cytochrome P450 3A4 (CYP3A4) with the IC₅₀ value of 0.055 μM. CYP3A4-IN-2 is a ritonavir analogue with increased hydrophobicity of the R2 side group and stronger inhibitory effect compared to ritonavir. CYP3A4-IN-2 can be used as an antiviral agent and immunosuppressants .

HY-17420S

Cyclophosphamide-d4	DNA Alkylator/Crosslinker	Cancer
Cyclophosphamide-d₄ is the deuterium labeled Cyclophosphamide. Cyclophosphamide is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic activity, a immunosuppressant[1][2].

HY-B0214S

Prednisone-d8 Dehydrocortisone-d₈	Glucocorticoid Receptor Apoptosis	Inflammation/Immunology Endocrinology Cancer
Prednisone-d₈ is the deuterium labeled Prednisone. Prednisone (Adasone) is a synthetic corticosteroid agent that is particularly effective as an immunosuppressant compound.

HY-17420S1

Cyclophosphamide-d8	Isotope-Labeled Compounds DNA Alkylator/Crosslinker	Cancer
Cyclophosphamide-d₈ is deuterium labeled Cyclophosphamide. Cyclophosphamide is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic activity, a immunosuppressant.

HY-108251S

Methotrexate metabolite-d3 DAMPA-d₃	Isotope-Labeled Compounds Antifolate Drug Metabolite	Inflammation/Immunology
Methotrexate metabolite-d₃ is the deuterium labeled Methotrexate metabolite. Methotrexate metabolite (DAMPA), the active metabolite of Methotrexate. Methotrexate is a folic acid antagonist that is widely used as an immunosuppressant and chemotherapeutic agent[1].

HY-17420R

Cyclophosphamide (Standard)	DNA Alkylator/Crosslinker	Cancer
Cyclophosphamide (Standard) is the analytical standard of Cyclophosphamide. This product is intended for research and analytical applications. Cyclophosphamide is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic activity, a immunosuppressant.

HY-133887

Methotrexate α-tert-butyl ester	Antifolate DNA/RNA Synthesis	Cancer
Methotrexate α-tert-butyl ester, capped by OtBu, significantly reduces tumor growth in HT1080 tumor bearing mice. Methotrexate is an antimetabolite and antifolate agent and is also an immunosuppressant and antineoplastic agent .

HY-W019721R

Cyclosporin D (Standard)	Nuclear Factor of activated T Cells (NFAT)	Inflammation/Immunology
Cyclosporin D (Standard) is the analytical standard of Cyclosporin D. This product is intended for research and analytical applications. Cyclosporin D, a metabolite of Cyclosporin A, is a weak immunosuppressant. Cyclosporin D is used as internal standard for quantification of Cyclosporin A . Cyclosporin A is a potent immunosuppressant agent, suppress T cell activation by inhibiting calcineurin and the calcineurin-dependent transcription factors nuclear factor of activated T cells (NFAc) .

HY-A0133R

Chlorphenesin (Standard)	Bacterial Fungal	Inflammation/Immunology Cancer
Chlorphenesin (Standard) is the analytical standard of Chlorphenesin. This product is intended for research and analytical applications. Chlorphenesin is a reversible antigen-associated immunosuppressant. Chlorphenesin is an antibacterial and antifungal agent used in numerous eye care cosmetics .

HY-14519

Methotrexate Maximum Cited Publications 38 Publications Verification Amethopterin; CL14377; WR19039	Antifolate DNA/RNA Synthesis ADC Cytotoxin Apoptosis Bacterial	Inflammation/Immunology Cancer
Methotrexate (Amethopterin), an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis. Methotrexate, also an immunosuppressant and antineoplastic agent, is used for the research of rheumatoid arthritis and a number of different cancers (such as acute lymphoblastic leukemia) .

HY-14519D

Methotrexate monohydrate Amethopterin monohydrate; CL14377 monohydrate; WR19039 monohydrate	Antifolate DNA/RNA Synthesis ADC Cytotoxin Apoptosis Bacterial	Inflammation/Immunology Cancer
Methotrexate (Amethopterin) monohydrate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis. Methotrexate monohydrate, also an immunosuppressant and antineoplastic agent, is used for the research of rheumatoid arthritis and a number of different cancers (such as acute lymphoblastic leukemia) .

HY-17461A

Cortisone acetate 1 Publications Verification Cortisone 21-acetate	Glucocorticoid Receptor Endogenous Metabolite	Inflammation/Immunology Endocrinology
Cortisone acetate (Cortisone 21-acetate), an oxidized metabolite of Cortisol (a Glucocorticoid). Cortisone acetate acts as an immunosuppressant and anti-inflammatory agent. Cortisone acetate can partially intervene in binding of Glucocorticoid to Glucocorticoid-receptor at high concentrations .

HY-108251R

Methotrexate metabolite (Standard) DAMPA (Standard)	Antifolate Drug Metabolite Dihydrofolate reductase (DHFR) Parasite	Infection Inflammation/Immunology
Methotrexate metabolite (Standard) is the analytical standard of Methotrexate metabolite. This product is intended for research and analytical applications. Methotrexate metabolite (DAMPA), the active metabolite of Methotrexate. Methotrexate is a folic acid antagonist that is widely used as an immunosuppressant and chemotherapeutic agent .

HY-14519A

Methotrexate disodium Maximum Cited Publications 38 Publications Verification Amethopterin disodium; CL14377 disodium; WR19039 disodium	Antifolate DNA/RNA Synthesis ADC Cytotoxin Apoptosis Bacterial	Inflammation/Immunology Cancer
Methotrexate (Amethopterin) disodium, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis. Methotrexate disodium, also an immunosuppressant and antineoplastic agent, is used for the research of rheumatoid arthritis and a number of different cancers (such as acute lymphoblastic leukemia) .

HY-17461

Cortisone 2 Publications Verification 17-Hydroxy-11-dehydrocorticosterone; Kendall's compound E	Glucocorticoid Receptor Endogenous Metabolite	Inflammation/Immunology Endocrinology
Cortisone (17-Hydroxy-11-dehydrocorticosterone), an oxidized metabolite of Cortisol (a Glucocorticoid). Cortisone acts as an immunosuppressant and anti-inflammatory agent. Cortisone can partially intervene in binding of Glucocorticoid to Glucocorticoid-receptor at high concentrations .

HY-14519S1

Methotrexate-d3 diammonium	Isotope-Labeled Compounds	Metabolic Disease Inflammation/Immunology Cancer
Methotrexate-d₃ diammonium is the deuterium labeled Methotrexate diammonium. Methotrexate (Amethopterin), an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis. Methotrexate, also an immunosuppressant and antineoplastic agent, is used for the research of rheumatoid arthritis and a number of different cancers (such as acute lymphoblastic leukemia) .

HY-14519R

Methotrexate (Standard)	Antifolate DNA/RNA Synthesis ADC Cytotoxin Apoptosis Bacterial	Inflammation/Immunology Cancer
Methotrexate (Standard) is the analytical standard of Methotrexate. This product is intended for research and analytical applications. Methotrexate (Amethopterin), an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis. Methotrexate, also an immunosuppressant and antineoplastic agent, is used for the research of rheumatoid arthritis and a number of different cancers (such as acute lymphoblastic leukemia) .

HY-14519S

Methotrexate-d3	Antifolate DNA/RNA Synthesis ADC Cytotoxin Apoptosis	Inflammation/Immunology Cancer
Methotrexate-d₃ (Amethopterin-d3) is the deuterium labeled Methotrexate. Methotrexate (Amethopterin), an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis. Methotrexate, also an immunosuppressant and antineoplastic agent, is used for the research of rheumatoid arthritis and a number of different cancers (such as acute lymphoblastic leukemia)[1][2][3].

HY-17461AR

Cortisone acetate (Standard) 1 Publications Verification Cortisone 21-acetate (Standard)	Glucocorticoid Receptor Endogenous Metabolite	Inflammation/Immunology Endocrinology
Cortisone acetate (Standard) is the analytical standard of Cortisone acetate. This product is intended for research and analytical applications. Cortisone acetate (Cortisone 21-acetate), an oxidized metabolite of Cortisol (a Glucocorticoid). Cortisone acetate acts as an immunosuppressant and anti-inflammatory agent. Cortisone acetate can partially intervene in binding of Glucocorticoid to Glucocorticoid-receptor at high concentrations .

HY-17461S1

Cortisone-d8	Isotope-Labeled Compounds Glucocorticoid Receptor Endogenous Metabolite	Inflammation/Immunology Endocrinology
Cortisone-d₈ is the deuterium labeled Cortisone. Cortisone (17-Hydroxy-11-dehydrocorticosterone), an oxidized metabolite of Cortisol (a Glucocorticoid). Cortisone acts as an immunosuppressant and anti-inflammatory agent. Cortisone can partially intervene in binding of Glucocorticoid to Glucocorticoid-receptor at high concentrations[1][3][4].

HY-17461S

Cortisone-13C3	Glucocorticoid Receptor Endogenous Metabolite	Inflammation/Immunology Endocrinology
Cortisone- ¹³C₃ is the ¹³C-labeled Cortisone. Cortisone (17-Hydroxy-11-dehydrocorticosterone), an oxidized metabolite of Cortisol (a Glucocorticoid). Cortisone acts as an immunosuppressant and anti-inflammatory agent. Cortisone can partially intervene in binding of Glucocorticoid to Glucocorticoid-receptor at high concentrations[1][3][4].

HY-17461S3

Cortisone-d2 17-Hydroxy-11-dehydrocorticosterone-d₂; Kendall's compound E-d₂	Isotope-Labeled Compounds Glucocorticoid Receptor Endogenous Metabolite	Endocrinology
Cortisone-d₂ is the deuterium labeled Cortisone. Cortisone (17-Hydroxy-11-dehydrocorticosterone), an oxidized metabolite of Cortisol (a Glucocorticoid). Cortisone acts as an immunosuppressant and anti-inflammatory agent. Cortisone can partially intervene in binding of Glucocorticoid to Glucocorticoid-receptor at high concentrations[1][3][4][5].

HY-17461R

Cortisone (Standard) 2 Publications Verification 17-Hydroxy-11-dehydrocorticosterone(Standard); Kendall's compound E (Standard)	Glucocorticoid Receptor Endogenous Metabolite	Inflammation/Immunology Endocrinology
Cortisone (Standard) is the analytical standard of Cortisone. This product is intended for research and analytical applications. Cortisone (17-Hydroxy-11-dehydrocorticosterone), an oxidized metabolite of Cortisol (a Glucocorticoid). Cortisone acts as an immunosuppressant and anti-inflammatory agent. Cortisone can partially intervene in binding of Glucocorticoid to Glucocorticoid-receptor at high concentrations .

HY-13765

6-Thioguanine 5+ Cited Publications Thioguanine; 2-Amino-6-purinethiol	SARS-CoV Deubiquitinase DNA Methyltransferase Autophagy Apoptosis Endogenous Metabolite	Infection Inflammation/Immunology Cancer
6-Thioguanine (Thioguanine; 2-Amino-6-purinethiol) is an anti-leukemia and immunosuppressant agent, acts as an inhibitor of SARS and MERS coronavirus papain-like proteases (PLpros) and also potently inhibits USP2 activity, with IC₅₀s of 25 μM and 40 μM for Plpros and recombinant human USP2, respectively.

HY-P99328

Tucotuzumab Anti-EPCAM Recombinant Antibody; huKS-IL2	Interleukin Related	Inflammation/Immunology Cancer
Tucotuzumab (Anti-EPCAM Recombinant Antibody) is an antigen-specific IgG1 monoclonal antibody that targets human epithelial cell adhesion molecule (EpCAM). Tucotuzumab links two IL-2 molecules and is an immunosuppressant and anti-tumor active molecule .

HY-13765R

6-Thioguanine (Standard)	SARS-CoV Deubiquitinase DNA Methyltransferase Autophagy Apoptosis Endogenous Metabolite	Infection Inflammation/Immunology Cancer
6-Thioguanine (Standard) is the analytical standard of 6-Thioguanine. This product is intended for research and analytical applications. 6-Thioguanine (Thioguanine; 2-Amino-6-purinethiol) is an anti-leukemia and immunosuppressant agent, acts as an inhibitor of SARS and MERS coronavirus papain-like proteases (PLpros) and also potently inhibits USP2 activity, with IC₅₀s of 25 μM and 40 μM for Plpros and recombinant human USP2, respectively.

HY-108251

Methotrexate metabolite 1 Publications Verification DAMPA	Antifolate Drug Metabolite Dihydrofolate reductase (DHFR) Parasite	Infection Inflammation/Immunology
Methotrexate metabolite (DAMPA) is an active metabolite of Methotrexate. Methotrexate is a Folic acid (HY-16637) antagonist, widely used as an immunosuppressant. Methotrexate metabolite is an antimalarial agent that inhibits parasite growth under physiological folic acid conditions, with IC₅₀ values of 446 nM and 812 nM against folic acid-sensitive strains and highly resistant strains, respectively. Methotrexate metabolite exhibits pharmacokinetic characteristics of rapid clearance and extensive metabolism, with a mean clearance rate of 1.9 l/kg/h and a mean terminal half-life of 51 minutes. Methotrexate metabolite is promising for research in the field of inflammation .

Cat. No.	Product Name	Target	Research Area

HY-W019721

Cyclosporin D	Nuclear Factor of activated T Cells (NFAT)	Inflammation/Immunology
Cyclosporin D, a metabolite of Cyclosporin A, is a weak immunosuppressant. Cyclosporin D is used as internal standard for quantification of Cyclosporin A . Cyclosporin A is a potent immunosuppressant agent, suppress T cell activation by inhibiting calcineurin and the calcineurin-dependent transcription factors nuclear factor of activated T cells (NFAc) .

HY-W019721R

Cyclosporin D (Standard)	Nuclear Factor of activated T Cells (NFAT)	Inflammation/Immunology
Cyclosporin D (Standard) is the analytical standard of Cyclosporin D. This product is intended for research and analytical applications. Cyclosporin D, a metabolite of Cyclosporin A, is a weak immunosuppressant. Cyclosporin D is used as internal standard for quantification of Cyclosporin A . Cyclosporin A is a potent immunosuppressant agent, suppress T cell activation by inhibiting calcineurin and the calcineurin-dependent transcription factors nuclear factor of activated T cells (NFAc) .

Cat. No.	Product Name	Target	Research Area

HY-P99152

Muromonab	CD3	Inflammation/Immunology Cancer
Muromonab is a monoclonal antibody targeting the CD3 receptor. Muromonab can block all cytotoxic T cell function. Muromonab also as an immunosuppressant agent given to reduce acute solid organ transplant rejection .

HY-P99328

Tucotuzumab Anti-EPCAM Recombinant Antibody; huKS-IL2	Interleukin Related	Inflammation/Immunology Cancer
Tucotuzumab (Anti-EPCAM Recombinant Antibody) is an antigen-specific IgG1 monoclonal antibody that targets human epithelial cell adhesion molecule (EpCAM). Tucotuzumab links two IL-2 molecules and is an immunosuppressant and anti-tumor active molecule .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-P99152

Muromonab	Classification of Application Fields Disease Research Fields Cancer	CD3
Muromonab is a monoclonal antibody targeting the CD3 receptor. Muromonab can block all cytotoxic T cell function. Muromonab also as an immunosuppressant agent given to reduce acute solid organ transplant rejection .

HY-W019721

Cyclosporin D	Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Inflammation/Immunology Disease Research Fields	Nuclear Factor of activated T Cells (NFAT)
Cyclosporin D, a metabolite of Cyclosporin A, is a weak immunosuppressant. Cyclosporin D is used as internal standard for quantification of Cyclosporin A . Cyclosporin A is a potent immunosuppressant agent, suppress T cell activation by inhibiting calcineurin and the calcineurin-dependent transcription factors nuclear factor of activated T cells (NFAc) .

HY-17461A

Cortisone acetate 1 Publications Verification Cortisone 21-acetate	Structural Classification Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields Steroids	Glucocorticoid Receptor Endogenous Metabolite
Cortisone acetate (Cortisone 21-acetate), an oxidized metabolite of Cortisol (a Glucocorticoid). Cortisone acetate acts as an immunosuppressant and anti-inflammatory agent. Cortisone acetate can partially intervene in binding of Glucocorticoid to Glucocorticoid-receptor at high concentrations .

HY-17461

Cortisone 2 Publications Verification 17-Hydroxy-11-dehydrocorticosterone; Kendall's compound E	Structural Classification Microorganisms Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields Steroids	Glucocorticoid Receptor Endogenous Metabolite
Cortisone (17-Hydroxy-11-dehydrocorticosterone), an oxidized metabolite of Cortisol (a Glucocorticoid). Cortisone acts as an immunosuppressant and anti-inflammatory agent. Cortisone can partially intervene in binding of Glucocorticoid to Glucocorticoid-receptor at high concentrations .

HY-17461AR

Cortisone acetate (Standard) 1 Publications Verification Cortisone 21-acetate (Standard)	Structural Classification Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields Steroids	Glucocorticoid Receptor Endogenous Metabolite
Cortisone acetate (Standard) is the analytical standard of Cortisone acetate. This product is intended for research and analytical applications. Cortisone acetate (Cortisone 21-acetate), an oxidized metabolite of Cortisol (a Glucocorticoid). Cortisone acetate acts as an immunosuppressant and anti-inflammatory agent. Cortisone acetate can partially intervene in binding of Glucocorticoid to Glucocorticoid-receptor at high concentrations .

HY-17461R

Cortisone (Standard) 2 Publications Verification 17-Hydroxy-11-dehydrocorticosterone(Standard); Kendall's compound E (Standard)	Structural Classification Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields Steroids	Glucocorticoid Receptor Endogenous Metabolite
Cortisone (Standard) is the analytical standard of Cortisone. This product is intended for research and analytical applications. Cortisone (17-Hydroxy-11-dehydrocorticosterone), an oxidized metabolite of Cortisol (a Glucocorticoid). Cortisone acts as an immunosuppressant and anti-inflammatory agent. Cortisone can partially intervene in binding of Glucocorticoid to Glucocorticoid-receptor at high concentrations .

HY-13765

6-Thioguanine Maximum Cited Publications 9 Publications Verification Thioguanine; 2-Amino-6-purinethiol	Infection Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields Cancer	SARS-CoV Deubiquitinase DNA Methyltransferase Autophagy Apoptosis Endogenous Metabolite
6-Thioguanine (Thioguanine; 2-Amino-6-purinethiol) is an anti-leukemia and immunosuppressant agent, acts as an inhibitor of SARS and MERS coronavirus papain-like proteases (PLpros) and also potently inhibits USP2 activity, with IC₅₀s of 25 μM and 40 μM for Plpros and recombinant human USP2, respectively.

HY-P99328

Tucotuzumab Anti-EPCAM Recombinant Antibody; huKS-IL2	Classification of Application Fields Disease Research Fields Cancer	Interleukin Related
Tucotuzumab (Anti-EPCAM Recombinant Antibody) is an antigen-specific IgG1 monoclonal antibody that targets human epithelial cell adhesion molecule (EpCAM). Tucotuzumab links two IL-2 molecules and is an immunosuppressant and anti-tumor active molecule .

HY-W019721R

Cyclosporin D (Standard)	Structural Classification Natural Products Microorganisms Source classification	Nuclear Factor of activated T Cells (NFAT)
Cyclosporin D (Standard) is the analytical standard of Cyclosporin D. This product is intended for research and analytical applications. Cyclosporin D, a metabolite of Cyclosporin A, is a weak immunosuppressant. Cyclosporin D is used as internal standard for quantification of Cyclosporin A . Cyclosporin A is a potent immunosuppressant agent, suppress T cell activation by inhibiting calcineurin and the calcineurin-dependent transcription factors nuclear factor of activated T cells (NFAc) .

HY-13765R

6-Thioguanine (Standard)	Structural Classification Natural Products Source classification Endogenous metabolite	SARS-CoV Deubiquitinase DNA Methyltransferase Autophagy Apoptosis Endogenous Metabolite
6-Thioguanine (Standard) is the analytical standard of 6-Thioguanine. This product is intended for research and analytical applications. 6-Thioguanine (Thioguanine; 2-Amino-6-purinethiol) is an anti-leukemia and immunosuppressant agent, acts as an inhibitor of SARS and MERS coronavirus papain-like proteases (PLpros) and also potently inhibits USP2 activity, with IC₅₀s of 25 μM and 40 μM for Plpros and recombinant human USP2, respectively.

Cat. No.	Product Name	Chemical Structure

HY-14519S1

Methotrexate-d3 diammonium

Methotrexate-d₃ diammonium is the deuterium labeled Methotrexate diammonium. Methotrexate (Amethopterin), an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis. Methotrexate, also an immunosuppressant and antineoplastic agent, is used for the research of rheumatoid arthritis and a number of different cancers (such as acute lymphoblastic leukemia) .

HY-17461S1

Cortisone-d8
Cortisone-d₈ is the deuterium labeled Cortisone. Cortisone (17-Hydroxy-11-dehydrocorticosterone), an oxidized metabolite of Cortisol (a Glucocorticoid). Cortisone acts as an immunosuppressant and anti-inflammatory agent. Cortisone can partially intervene in binding of Glucocorticoid to Glucocorticoid-receptor at high concentrations[1][3][4].

HY-17461S

Cortisone-13C3
Cortisone- ¹³C₃ is the ¹³C-labeled Cortisone. Cortisone (17-Hydroxy-11-dehydrocorticosterone), an oxidized metabolite of Cortisol (a Glucocorticoid). Cortisone acts as an immunosuppressant and anti-inflammatory agent. Cortisone can partially intervene in binding of Glucocorticoid to Glucocorticoid-receptor at high concentrations[1][3][4].

HY-17420S

Cyclophosphamide-d4
Cyclophosphamide-d₄ is the deuterium labeled Cyclophosphamide. Cyclophosphamide is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic activity, a immunosuppressant[1][2].

HY-B0214S

Prednisone-d8
Prednisone-d₈ is the deuterium labeled Prednisone. Prednisone (Adasone) is a synthetic corticosteroid agent that is particularly effective as an immunosuppressant compound.

HY-17420S1

Cyclophosphamide-d8
Cyclophosphamide-d₈ is deuterium labeled Cyclophosphamide. Cyclophosphamide is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic activity, a immunosuppressant.

HY-108251S

Methotrexate metabolite-d3
Methotrexate metabolite-d₃ is the deuterium labeled Methotrexate metabolite. Methotrexate metabolite (DAMPA), the active metabolite of Methotrexate. Methotrexate is a folic acid antagonist that is widely used as an immunosuppressant and chemotherapeutic agent[1].

HY-14519S

Methotrexate-d3

Methotrexate-d₃ (Amethopterin-d3) is the deuterium labeled Methotrexate. Methotrexate (Amethopterin), an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis. Methotrexate, also an immunosuppressant and antineoplastic agent, is used for the research of rheumatoid arthritis and a number of different cancers (such as acute lymphoblastic leukemia)[1][2][3].

HY-17461S3

Cortisone-d2
Cortisone-d₂ is the deuterium labeled Cortisone. Cortisone (17-Hydroxy-11-dehydrocorticosterone), an oxidized metabolite of Cortisol (a Glucocorticoid). Cortisone acts as an immunosuppressant and anti-inflammatory agent. Cortisone can partially intervene in binding of Glucocorticoid to Glucocorticoid-receptor at high concentrations[1][3][4][5].

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immunosuppressant agent

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