Cortisone-¹³C₃

Cat. No.: HY-17461S: FAQs
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Cortisone-¹³C₃ is the ¹³C-labeled Cortisone. Cortisone (17-Hydroxy-11-dehydrocorticosterone), an oxidized metabolite of Cortisol (a Glucocorticoid). Cortisone acts as an immunosuppressant and anti-inflammatory agent. Cortisone can partially intervene in binding of Glucocorticoid to Glucocorticoid-receptor at high concentrations[1][3][4].

For research use only. We do not sell to patients.

Cortisone-<sup>13</sup>C<sub>3</sub> Chemical Structure

Cortisone-¹³C₃ Chemical Structure

CAS No. : 2350278-95-2

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100μg（275.16 μM * 1 mL in Methanol）	USD 2150	In-stock	Estimated Time of Arrival: December 31

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Based on 1 publication(s) in Google Scholar

Other Forms of Cortisone-¹³C₃:

Cortisone In-stock

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Biological Activity
Purity & Documentation
References
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Description	Cortisone-¹³C₃ is the ¹³C-labeled Cortisone. Cortisone (17-Hydroxy-11-dehydrocorticosterone), an oxidized metabolite of Cortisol (a Glucocorticoid). Cortisone acts as an immunosuppressant and anti-inflammatory agent. Cortisone can partially intervene in binding of Glucocorticoid to Glucocorticoid-receptor at high concentrations[1][3][4].
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Cortisone-¹³C₃ Related Antibodies
Molecular Weight	363.42
Formula	C₁₈¹³C₃H₂₈O₅
CAS No.	2350278-95-2
Unlabeled CAS	53-06-5
Appearance	Liquid
Color	Colorless to light yellow
SMILES	O=C(CO)[C@@]1(O)CCC([C@]1(C)C2)C3CCC4=[13C][13C]([13C]C[C@]4(C)C3C2=O)=O
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Solution, -20°C, 2 years
Purity & Documentation	Data Sheet (273 KB) Handling Instructions (2659 KB)
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief] [2]. Hirano T, et, al. Cortisone counteracts apoptosis-inducing effect of cortisol in human peripheral-blood mononuclear cells. Int Immunopharmacol. 2001 Nov;1(12):2109-15. [Content Brief] [3]. McCue RE, et, al. The effect of cortisone on the accumulation, activation, and necrosis of macrophages in tuberculous lesions. Inflammation. 1978 Jun;3(2):159-76. [Content Brief] [4]. Seleem D, et, al. In Vivo Antifungal Activity of Monolaurin against Candida albicans Biofilms. Biol Pharm Bull. 2018;41(8):1299-1302. [Content Brief] [5]. Rusu VM, et, al. In vivo effects of cortisone on the B cell line in chickens. J Immunol. 1975 Nov;115(5):1370-4. [Content Brief]