Search Result

Results for "

intestine

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Acyltransferase (1) Apoptosis (5) Autophagy (1) Bacterial (4) Biochemical Assay Reagents (1) Chloride Channel (2) Dopamine Receptor (4) Endogenous Metabolite (19) Fluorescent Dye (3) FXR (3) G protein-coupled Bile Acid Receptor 1 (2) GCGR (1) Glucosidase (1) GLUT (2) Histamine Receptor (5) Interleukin Related (1) Isotope-Labeled Compounds (2) mAChR (6) MMP (1) Neurokinin Receptor (3) Parasite (1) Potassium Channel (1) Proteasome (1) Ras (1) Ser/Thr Protease (1) SGLT (2) TET Protein (1) TNF Receptor (1) VD/VDR (1)
By Research Areas:	Cancer (17) Cardiovascular Disease (4) Endocrinology (7) Infection (6) Inflammation/Immunology (13) Metabolic Disease (24) Neurological Disease (14)

By Targets:

Acyltransferase (1)

Apoptosis (5)

Autophagy (1)

Bacterial (4)

Biochemical Assay Reagents (1)

Chloride Channel (2)

Dopamine Receptor (4)

Endogenous Metabolite (19)

Fluorescent Dye (3)

FXR (3)

G protein-coupled Bile Acid Receptor 1 (2)

GCGR (1)

Glucosidase (1)

GLUT (2)

Histamine Receptor (5)

Interleukin Related (1)

Isotope-Labeled Compounds (2)

mAChR (6)

MMP (1)

Neurokinin Receptor (3)

Parasite (1)

Potassium Channel (1)

Proteasome (1)

Ras (1)

Ser/Thr Protease (1)

SGLT (2)

TET Protein (1)

TNF Receptor (1)

VD/VDR (1)

By Research Areas:

Cancer (17)

Cardiovascular Disease (4)

Endocrinology (7)

Infection (6)

Inflammation/Immunology (13)

Metabolic Disease (24)

Neurological Disease (14)

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P2818

Alkaline phosphatase, Bovine intestine 1 Publications Verification Apase	Endogenous Metabolite	Metabolic Disease Cancer
Alkaline phosphatase, Bovine intestine (Apase) is a membrane-bound glycoprotein that catalyzes the hydrolysis of phosphate monoesters at alkaline pH. Alkaline phosphatase can be used in molecular biology and enzyme-free analysis. Inhibition of tissue nonspecific alkaline phosphatase can block intracellular lipid accumulation .

HY-143712

Allolithocholic acid	Endogenous Metabolite	Metabolic Disease
Allolithocholic acid is a steroid acid could found in normal serum and feces. Allolithocholic acid facilitates excretion, absorption, and transport of fats and sterols in the intestine and liver .

HY-B1132

Clidinium bromide Ro 2-3773	mAChR	Neurological Disease
Clidinium bromide is a quaternary amine antimuscarinic agent. Clidinium bromide may help symptoms of cramping and abdominal/stomach pain by decreasing stomach acid, and slowing the intestines in vivo .

HY-N7387

3-Oxocholic acid	Endogenous Metabolite	Metabolic Disease
3-Oxocholic acid is an oxo-bile acid metabolite and also a major degradation product from cholic by C. perfringens in the intestine. 3-Oxocholic acid is steroid acid found predominantly in bile of mammals .

HY-P2818B

Alkaline phosphatase, Chicken Intestine Apase, Chicken intestine	Endogenous Metabolite	Metabolic Disease
Alkaline phosphatase, Chicken Intestine (Apase, Chicken Intestine) is an ubiquitous membrane-bound glycoprotein that catalyzes the hydrolysis of phosphate monoesters at basic pH values .

HY-NP111

Highly purified Type V collagen, from mouse intestine Mouse Type V collagen, immunization grade	MMP	Inflammation/Immunology
Highly purified Type V collagen, from mouse intestine (Mouse Type II collagen, immunization grade) is an immune grade collagen derived from mouse intestine, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .

HY-156964

Benzmalecene	Others	Cancer
Benzmalecene is a Krebs cycle inhibitor, and inhibits the active absorption of taurocholate by the small intestine in vivo and in vitro .

HY-P1067A

Enterostatin(human,mouse,rat) TFA	Endogenous Metabolite	Metabolic Disease
Enterostatin (human,mouse,rat) TFA is a pentapeptide mainly formed in the intestine by the cleavage of secreted pancreatic procolipase. Enterostatin selectively reduces fat intake, bodyweight, and body fat in vivo .

HY-142957

NaPi2b-IN-1	Others	Others
NaPi2b-IN-1 is a potent and orally active inhibitor of sodium-dependent phosphate transport protein 2b (NaPi2b) with an IC₅₀ of 64 nM. NaPi2b is primarily expressed in the small intestine, lungs, and testes and plays an important role in phosphate homeostasis. NaPi2b-IN-1 has the potential for the research of hyperphosphatemia .

HY-B1132R

Clidinium bromide (Standard)	mAChR	Neurological Disease
Clidinium (bromide) (Standard) is the analytical standard of Clidinium (bromide). This product is intended for research and analytical applications. Clidinium bromide is a quaternary amine antimuscarinic agent. Clidinium bromide may help symptoms of cramping and abdominal/stomach pain by decreasing stomach acid, and slowing the intestines in vivo .

HY-B0310

Nizatidine	Histamine Receptor	Inflammation/Immunology Endocrinology Cancer
Nizatidine is a potent and orally active histamine H₂ receptor antagonist, can be used for the research of stomach?and?intestines ulcers. Nizatidine works by decreasing the secretion of gastric?acid the stomach makes and prevent ulcers from coming back after they have healed in animal models .

HY-113586

Besifovir Dipivoxil LB-80380	Others	Infection
Besifovir Dipivoxil (LB-80380), an analog of guanosine monophosphate, is an acyclic nucleotide phosphonate with antiviral effect. Besifovir Dipivoxil is rapidly converted by the liver and intestine to the intermediate metabolite LB80331 via the esterification process, subsequently phosphorylated into the di- and triphosphate forms, which act as antiviral DNA synthesis inhibitors. Besifovir Dipivoxil is promising for research of chronic hepatitis B .

HY-154912

PAT1inh-B01	Others	Inflammation/Immunology
PAT1inh-B01 is a selective SLC26A6 inhibitor. PAT1inh-B01 inhibits PAT1 (a Cl ^-/HCO3 ^- exchanger)-mediated anion exchange (IC₅₀: 350 nM). PAT1inh-B01 blocks fluid absorption in small intestine. PAT1inh-B01 can be used for research of small intestinal hyposecretory disorders .

HY-154912A

PAT1inh-B01 hydrochloride	Others	Inflammation/Immunology
PAT1inh-B01 hydrocholide is a selective SLC26A6 inhibitor. PAT1inh-B01 hydrocholide inhibits PAT1 (a Cl ^-/HCO3 ^- exchanger)-mediated anion exchange (IC₅₀: 350 nM). PAT1inh-B01 hydrocholide blocks fluid absorption in small intestine. PAT1inh-B01 hydrocholide can be used for research of small intestinal hyposecretory disorders .

HY-B0310R

Nizatidine (Standard)	Histamine Receptor	Inflammation/Immunology Endocrinology Cancer
Nizatidine (Standard) is the analytical standard of Nizatidine. This product is intended for research and analytical applications. Nizatidine is a potent and orally active histamine H₂ receptor antagonist, can be used for the research of stomach and intestines ulcers. Nizatidine works by decreasing the secretion of gastric acid the stomach makes and prevent ulcers from coming back after they have healed in animal models .

HY-B1278S1

α-Tocopherol-d6 acetate	Endogenous Metabolite	Metabolic Disease Cancer
α-Tocopherol-d₆ (acetate) is the deuterium labeled D-α-Tocopherol acetate. D-α-Tocopherol acetate (D-Vitamin E acetate) can be hydrolyzed to d-alpha-tocopherol (VE) and absorbed in the small intestine[1].

HY-B0411S

Domperidone-d6	Dopamine Receptor	Neurological Disease
Domperidone-d₆ is the deuterium labeled Domperidone. Domperidone (R33812) is a selective dopamine-2 receptor antagonist. Domperidone acts as an antiemetic and a prokinetic agent through its effects on the chemoreceptor trigger zone and motor function of the stomach and small intestine[1][2].

HY-B0967

Phthalylsulfacetamide	Bacterial	Infection
Phthalylsulfacetamide is a sulfa drug, after oral administration, slowly decompose in the intestine,and release sulfacetamide ,generating antibacterial effect.

HY-B1278

D-α-Tocopherol acetate D-Vitamin E acetate	Endogenous Metabolite	Metabolic Disease Cancer
D-α-Tocopherol acetate (D-Vitamin E acetate) can be hydrolyzed to d-alpha-tocopherol (VE) and absorbed in the small intestine .

HY-156868

22-Hydroxyvitamin D3	VD/VDR	Metabolic Disease
22-Hydroxyvitamin D3 a novel vitamin D analog, that displays no vitamin D agonist activity in the intestine or in bone .

HY-B1731

Phenyl salicylate	Bacterial	Neurological Disease
Phenyl salicylate (PS) has antibacterial activity when hydrolyzed in small intestine and is often used as nervous system inhibitor and intestinal preservative .

HY-P1276

Men 10376 Neurokinin-2 receptor antagonist	Neurokinin Receptor	Endocrinology
Men 10376 is a selective tachykinin NK-2 receptor antagonist, with a K_i of 4.4 μM for rat small intestine NK-2 receptor.

HY-163072

FXR antagonist 3	FXR	Metabolic Disease
FXR antagonist 3 (V02-8) is an intestine-specific farnesoid X receptor (FXR) antagonist, with an IC₅₀ of 0.89 μM .

HY-N0169

Hyodeoxycholic acid HDCA	Endogenous Metabolite G protein-coupled Bile Acid Receptor 1	Metabolic Disease
Hyodeoxycholic acid is a secondary bile acid formed in the small intestine by the gut flora, and acts as a TGR5 (GPCR19) agonist, with an EC₅₀ of 31.6 µM in CHO cells.

HY-114392

Gly-β-MCA 10+ Cited Publications	FXR Autophagy	Metabolic Disease
Gly-β-MCA, a bile acid, is a potent, sable, intestine-selective and oral bioactive farnesoid X receptor (FXR) inhibitor that may be a candidate for the treatment of metabolic disorders .

HY-P1276A

Men 10376 TFA 1 Publications Verification Neurokinin-2 receptor antagonist TFA	Neurokinin Receptor	Endocrinology
Men 10376 TFA is a selective tachykinin NK-2 receptor antagonist, with a K_i of 4.4 μM for rat small intestine NK-2 receptor .

HY-105589

Liroldine HL 707	Parasite	Infection
Liroldine (Compound 10) is an anti-amebic agent that exhibits effective anti-amebic activity in both the intestines and livers of mice. Liroldine can be utilized for the research of amebiasis .

HY-129878

N-Trifluoroacetyladriamycin AD-41	Others	Cancer
N-Trifluoroacetyladriamycin (AD-41) is a chemotherapeutic compound with antitumor activity. N-Trifluoroacetyladriamycin exhibits the highest fluorescence and radioactivity levels in the small intestine and liver, indicating its significant accumulation in these tissues. N-Trifluoroacetyladriamycin also shows significant accumulation in the kidney, spleen, large intestine, lung, and heart. N-Trifluoroacetyladriamycin is a metabolite of Valrubicin, which is used to inhibit bladder cancer. The presence of N-Trifluoroacetyladriamycin and its derivatives may be related to the biotransformation of the compound and its antitumor mechanism .

HY-B1188S

Propantheline-d3 bromide	mAChR	Neurological Disease
Propantheline-d₃ (bromide) is the deuterium labeled Propantheline bromide. Propantheline bromide is an antimuscarinic agent, used for the treatment of hyperhidrosis, cramps or spasms of the stomach, intestines or bladder, and enuresis.

HY-113529

Stachyose tetrahydrate	Apoptosis Endogenous Metabolite	Cancer
Stachyose tetrahydrate, a functional oligosaccharide, acts as a prebiotic. Stachyose tetrahydrate can prevent indirectly colon cancer cell growth by promoting the proliferation of probiotics or producing beneficial materials in the intestine .

HY-B1188A

Propantheline	mAChR	Neurological Disease
Propantheline is an orally active mAChR antagonist. Propantheline can be used in the research of smooth muscle dysfunction, excessive sweating, cramps or spasms of the stomach, intestines or bladder, and involuntary urination .

HY-136750

Z-LLY-FMK Calpain Inhibitor IV	Apoptosis Proteasome	Cancer
Z-LLY-FMK (Calpain Inhibitor IV) is a calpain inhibitor, involved in apoptosis of many cell systems. Z-LLY-FMK inhibits the intestine apoptosis after common bile duct ligation .

HY-B1188

Propantheline bromide	mAChR	Neurological Disease
Propantheline bromide is an orally active mAChR antagonist. Propantheline bromide can be used in the research of smooth muscle dysfunction, excessive sweating, cramps or spasms of the stomach, intestines or bladder, and involuntary urination .

HY-B0411

Domperidone 5 Publications Verification R33812	Dopamine Receptor	Neurological Disease
Domperidone (R33812) is an orally active and selective dopamine-2 receptor antagonist. Domperidone acts as an antiemetic and a prokinetic agent through its effects on the chemoreceptor trigger zone and motor function of the stomach and small intestine .

HY-U00369

FCE 28654	Acyltransferase	Cardiovascular Disease
FCE 28654 is an inhibitor of acylCoA: cholesterol acyltransferase (ACAT), weakly inhibiting ACAT in microsomes from rabbit aorta and intestine, and monkey liver, with IC₅₀s of 2.55, 1.08 and 5.69 μM, respcetively.

HY-N0169S

Hyodeoxycholic acid-d5 HDCA-d₅	Endogenous Metabolite G protein-coupled Bile Acid Receptor 1	Metabolic Disease
Hyodeoxycholic acid-d₅ is the deuterium labeled Hyodeoxycholic acid. Hyodeoxycholic acid is a secondary bile acid formed in the small intestine by the gut flora, and acts as a TGR5 (GPCR19) agonist, with an EC50 of 31.6 µM in CHO cells.

HY-B0411A

Domperidone monomaleate 5 Publications Verification R33812 monomaleate	Dopamine Receptor	Neurological Disease
Domperidone (R33812) monomaleate is an orally active and selective dopamine-2 receptor antagonist. Domperidone monomaleate acts as an antiemetic and a prokinetic agent through its effects on the chemoreceptor trigger zone and motor function of the stomach and small intestine .

HY-P2879C

Cholesterol esterase, schizophyllum commune	Endogenous Metabolite	Metabolic Disease
Cholesterol esterase, Schizophyllum commune is an enzyme that catalyzes the hydrolysis of cholesterol esters into free cholesterol and fatty acids, facilitating the absorption of cholesterol in the intestine. Cholesterol esterase, Schizophyllum commune can be used in combination with cholesterol oxidase to measure cholesterol content .

HY-P2990

Enteropeptidase TMPRSS15	Ser/Thr Protease	Metabolic Disease
Enteropeptidase (TMPRSS15), a type II transmembrane serine protease and a physiological activator of trypsinogen. Enteropeptidase is associated with the brush border membrane (BBM) of the enterocytes in the upper small intestine. Trypsinogen is the primary substrate for Enteropeptidase. Enteropeptidase is involved in digestion in humans and animals .

HY-P3003

Cereulide	Apoptosis	Neurological Disease Inflammation/Immunology
Cereulide, a toxin depsipeptide, can be produced by Bacillus cereus. Cereulide induces cell apoptosis. Cereulide acts on mitochondria, leading to dysfunction in different organs (liver, pancreatic islet, brain, intestines, etc.) and body systems (immune system and nervous system) .

HY-135541

Darexaban maleate YM150 maleate	Others	Cardiovascular Disease
Darexaban maleate (YM150 maleate) is a direct factor Xa inhibitor with activity in preventing venous thromboembolism. The major metabolite of Darexaban maleate in humans is Darexaban glucitol, which acts pharmacologically. The glucitolation reaction of Darexaban maleate is mainly catalyzed by UGT1A9 and UGT1A10 in the human liver and intestine. The K(m) value of Darexaban maleate glucitolation in the liver is greater than 250 μM, while in the intestine it exhibits substrate inhibition kinetics with a K(m) value of 27.3 μM. The unbound K(m) value of Darexaban maleate is significantly reduced by the influence of fatty acid-free bovine serum albumin in both HLM and UGT1A9 .

HY-N9457

Norcholic acid	Others	Metabolic Disease Endocrinology
Norcholic acid is a normal minorbile C23 bile acid having four side chain and exsits in human urine and meconium. Norcholic acid can become prominent under certain pathological conditions. Norcholic acid is efficiently absorbed from intestine and quickly excreted into the bile but not into urine .

HY-145316

Vanin-1-IN-2	Others	Metabolic Disease
Vanin-1-IN-2 is a potent vanin-1 inhibitor with an IC₅₀ of 162 nM. Vanin-1 is a cell-surface-associated, glycosylphosphatidyl inositol (GPI)-anchored protein which is expressed at high levels in the kidney, liver, and small intestine .

HY-P3498

Elsiglutide ZP1846	GCGR	Others
Elsiglutide (ZP1846) is a GLP-2 analogue, an orally active and selective GLP-2 receptor agonist, increases cell proliferation and reduces apoptosis in the intestine. Elsiglutide improves Lapatinib (HY-50898)-induced diarrhoea in rat model .

HY-N10526

Isoglobotriaose Gala-3Galb-4Glc	Others	Others
Isoglobotriaose (Gala-3Galb-4Glc) is a glycosphingolipid found in mammalian tissues. Isoglobotriaose is an analogue of Globotriaose, the ganglioside derivatives of them locate in difference position of small intestine, isoglobotriaosylceramide is restricted to the nonepithelial residue, while globotriaosylceramide is in both compartments .

HY-118103

Coprostanol Coprostan-3-ol	Endogenous Metabolite	Others
Coprostanol (Coprostan-3-ol) is a fecal sterol formed by microbial reduction of cholesterol in the intestines of man and higher animals. Coprostanol can be used as an indicator sterol of fecal pollution. Coprostanol has been recognized as a good indicator of pollution of water resources by sewage discharges .

HY-P2317

Cecropin P1, porcine	Bacterial Endogenous Metabolite	Infection
Cecropin P1, porcine is an antibacterial peptide that can be isolated from the upper part of the small intestine of the pig. Cecropin P1, porcine shows antibacterial activity against Gram-negative bacteria. Cecropin P1, porcine shows antiviral activity and inhibits PRRSV infection .

HY-P2317A

Cecropin P1, porcine acetate	Bacterial Endogenous Metabolite	Infection
Cecropin P1, porcine acetate is an antibacterial peptide that can be isolated from the upper part of the small intestine of the pig. Cecropin P1, porcine acetate shows antibacterial activity against Gram-negative bacteria. Cecropin P1, porcine acetate shows antiviral activity and inhibits PRRSV infection .

HY-P1142

GLP-2(rat)	Apoptosis	Others
GLP-2(rat) is an intestinal growth factor. GLP-2(rat) stimulates cell proliferation and inhibits apoptosis. GLP-2(rat) enhances mucosal mass and function in residual small intestine after massive small bowel resection (MSBR) .

HY-P3069

γ-Neuropeptide (rabbit)	Neurokinin Receptor	Neurological Disease Endocrinology
γ-Neuropeptide (rabbit) can be isolated from rabbit intestine. γ-Neuropeptide is an endogenous neurokinin peptide that acts as a neurokinin 2 (NK2) receptor agonist. γ-Neuropeptide mediates hypothalamic-pituitary-adrenal (HPA) axis, as well as reproductive hormone release .

Cat. No.	Product Name

HY-L103

Anti-Colorectal Cancer Compound Library

1,725 compounds

Colorectal cancer (CRC), also known as bowel cancer, colon cancer, or rectal cancer, arises as adenocarcinoma from glandular epithelial cells of the large intestine comprised of the colon and rectum. The majority of cases of CRC are sporadic and result from risk factors, such as a sedentary lifestyle, obesity, processed diets, alcohol consumption and smoking. CRC is also a common preventable cancer.

Studies showed several cellular signaling pathways dysregulated in CRC, leading to the onset of malignant phenotypes. Therefore, it is necessary to analyze the signaling pathways involved in the occurrence and development of colorectal cancer to study the progression and drug treatment of colorectal cancer. Among them, Wnt/β-catenin, p53, TGF-β/SMAD, NF-κB, Notch, VEGF and other target genes and signaling pathways are the focus of research. MCE offers a unique collection of 1,725 compounds with identified and potential anti-colorectal cancer activity. MCE anti-colorectal cancer compound library is a useful tool for anti-colorectal cancer drugs screening and other related research.

Cat. No.	Product Name	Type

HY-111956B

D-Ala-Lys-AMCA hydrochloride	Fluorescent Dyes/Probes
D-Ala-Lys-AMCA hydrochloride is a known proton-coupled oligopeptide transporter 1 (PEPT1) substrate that emits blue fluorescence. D-Ala-Lys-AMCA hydrochloride may be transported into liver cancer cells and Caco-2 cells based on fluorescence analysis. D-Ala-Lys-AMCA hydrochloride can be used for characterizing PEPT1-specific substrates or inhibitors .

HY-111956

D-Ala-Lys-AMCA	Fluorescent Dyes/Probes
D-Ala-Lys-AMCA is a known proton-coupled oligopeptide transporter 1 (PEPT1) substrate that emits blue fluorescence. D-Ala-Lys-AMCA may be transported into liver cancer cells and Caco-2 cells based on fluorescence analysis. D-Ala-Lys-AMCA can be used for characterizing PEPT1-specific substrates or inhibitors .

HY-111956A

D-Ala-Lys-AMCA TFA	Fluorescent Dyes/Probes
D-Ala-Lys-AMCA TFA is a known proton-coupled oligopeptide transporter 1 (PEPT1) substrate that emits blue fluorescence. D-Ala-Lys-AMCA TFA may be transported into liver cancer cells and Caco-2 cells based on fluorescence analysis. D-Ala-Lys-AMCA TFA can be used for characterizing PEPT1-specific substrates or inhibitors .

Cat. No.	Product Name	Type

HY-NP111

Highly purified Type V collagen, from mouse intestine Mouse Type V collagen, immunization grade	Native Proteins
Highly purified Type V collagen, from mouse intestine (Mouse Type II collagen, immunization grade) is an immune grade collagen derived from mouse intestine, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .

HY-P2823

Trypsinogen

Biochemical Assay Reagents

Trypsinogen, a proenzyme synthesized in the pancreas, is activated to form trypsin by enterokinase upon reaching the small intestine lumen, where it opens a hexapeptide bond at the Lys6 - Ile7 junction, leading to the production of the active enzyme. This single polypeptide chain, composed of 229 amino acids and stabilized by six disulfide bridges, further autocatalytically converts additional trypsinogen into trypsin, which is initially present as β-trypsin before undergoing autolysis at the Lys131 - Ser132 site to form α-trypsin. As a serine protease, trypsin features His46 and Ser183 at its active site and exhibits optimal enzymatic activity at a pH range of 7 to 9.

Cat. No.	Product Name	Target	Research Area

HY-P1276A

Men 10376 TFA 1 Publications Verification Neurokinin-2 receptor antagonist TFA	Neurokinin Receptor	Endocrinology
Men 10376 TFA is a selective tachykinin NK-2 receptor antagonist, with a K_i of 4.4 μM for rat small intestine NK-2 receptor .

HY-P3151

Gliadin p31-43	Peptides	Inflammation/Immunology
Gliadin p31-43 is an undigested gliadin peptide. Gliadin p31-43 induces an innate immune response in the intestine and interferes with endocytic trafficking. Gliadin p31-43 can be used for celiac disease research .

HY-P1067A

Enterostatin(human,mouse,rat) TFA	Endogenous Metabolite	Metabolic Disease
Enterostatin (human,mouse,rat) TFA is a pentapeptide mainly formed in the intestine by the cleavage of secreted pancreatic procolipase. Enterostatin selectively reduces fat intake, bodyweight, and body fat in vivo .

HY-106128

Lagatide BN 52080	Peptides	Infection
Lagatide (BN 52080), a heptapeptide, is a short C-terminal analog of sorbin. Lagatide has proabsorptive and antisecretory effect in the different parts of the intestine. Lagatide can be used for the research of chronic diarrhea .

HY-P1276

Men 10376 Neurokinin-2 receptor antagonist	Neurokinin Receptor	Endocrinology
Men 10376 is a selective tachykinin NK-2 receptor antagonist, with a K_i of 4.4 μM for rat small intestine NK-2 receptor.

HY-P3611

Valosin (porcine)	Peptides	Metabolic Disease
Valosin (porcine) is a biologically active peptide with 25-amino-acid. Valosin (porcine) can be isolated recently from pig intestine. Valosin (porcine) can be used for the research of digestive system .

HY-P4839

GLP-2 (1-34) (human)	Peptides	Metabolic Disease
GLP-2 (1-34) (human) is a polypeptide released from the intestine within minutes after food intake. GLP-2 (1-34) (human) can be used for the research of bone remodeling processes .

HY-P3003

Cereulide	Apoptosis	Neurological Disease Inflammation/Immunology
Cereulide, a toxin depsipeptide, can be produced by Bacillus cereus. Cereulide induces cell apoptosis. Cereulide acts on mitochondria, leading to dysfunction in different organs (liver, pancreatic islet, brain, intestines, etc.) and body systems (immune system and nervous system) .

HY-P3498

Elsiglutide ZP1846	GCGR	Others
Elsiglutide (ZP1846) is a GLP-2 analogue, an orally active and selective GLP-2 receptor agonist, increases cell proliferation and reduces apoptosis in the intestine. Elsiglutide improves Lapatinib (HY-50898)-induced diarrhoea in rat model .

HY-P3151A

Gliadin p31-43 TFA	Peptides	Inflammation/Immunology
Gliadin p31-43 TFA is an undigested gliadin peptide. Gliadin p31-43 TFA induces an innate immune response in the intestine and interferes with endocytic trafficking. Gliadin p31-43 TFA can be used for celiac disease research .

HY-P2317

Cecropin P1, porcine	Bacterial Endogenous Metabolite	Infection
Cecropin P1, porcine is an antibacterial peptide that can be isolated from the upper part of the small intestine of the pig. Cecropin P1, porcine shows antibacterial activity against Gram-negative bacteria. Cecropin P1, porcine shows antiviral activity and inhibits PRRSV infection .

HY-P2317A

Cecropin P1, porcine acetate	Bacterial Endogenous Metabolite	Infection
Cecropin P1, porcine acetate is an antibacterial peptide that can be isolated from the upper part of the small intestine of the pig. Cecropin P1, porcine acetate shows antibacterial activity against Gram-negative bacteria. Cecropin P1, porcine acetate shows antiviral activity and inhibits PRRSV infection .

HY-P1142

GLP-2(rat)	Apoptosis	Others
GLP-2(rat) is an intestinal growth factor. GLP-2(rat) stimulates cell proliferation and inhibits apoptosis. GLP-2(rat) enhances mucosal mass and function in residual small intestine after massive small bowel resection (MSBR) .

HY-P3069

γ-Neuropeptide (rabbit)	Neurokinin Receptor	Neurological Disease Endocrinology
γ-Neuropeptide (rabbit) can be isolated from rabbit intestine. γ-Neuropeptide is an endogenous neurokinin peptide that acts as a neurokinin 2 (NK2) receptor agonist. γ-Neuropeptide mediates hypothalamic-pituitary-adrenal (HPA) axis, as well as reproductive hormone release .

HY-P1142A

GLP-2(rat) TFA	Apoptosis	Others
GLP-2(rat) TFA is an intestinal growth factor. GLP-2(rat) TFA stimulates cell proliferation and inhibits apoptosis. GLP-2(rat) TFA enhances mucosal mass and function in residual small intestine after massive small bowel resection (MSBR) .

HY-P5495

Uroguanylin-15 (Rat)	Peptides	Others
Uroguanylin-15 (Rat) is a biological active peptide. (Uroguanylin is a natriuretic peptide, a hormone that regulates sodium excretion by the kidney when excess NaCl is consumed. Uroguanylin and guanylin are related peptides that activate common guanylate cyclase signaling molecules in the intestine and kidney. Uroguanylin was isolated from urine and duodenum but was not detected in extracts from the colon of rats.)

HY-111956

D-Ala-Lys-AMCA	Fluorescent Dye	Cancer
D-Ala-Lys-AMCA is a known proton-coupled oligopeptide transporter 1 (PEPT1) substrate that emits blue fluorescence. D-Ala-Lys-AMCA may be transported into liver cancer cells and Caco-2 cells based on fluorescence analysis. D-Ala-Lys-AMCA can be used for characterizing PEPT1-specific substrates or inhibitors .

HY-111956B

D-Ala-Lys-AMCA hydrochloride	Fluorescent Dye	Cancer
D-Ala-Lys-AMCA hydrochloride is a known proton-coupled oligopeptide transporter 1 (PEPT1) substrate that emits blue fluorescence. D-Ala-Lys-AMCA hydrochloride may be transported into liver cancer cells and Caco-2 cells based on fluorescence analysis. D-Ala-Lys-AMCA hydrochloride can be used for characterizing PEPT1-specific substrates or inhibitors .

HY-111956A

D-Ala-Lys-AMCA TFA	Fluorescent Dye	Cancer
D-Ala-Lys-AMCA TFA is a known proton-coupled oligopeptide transporter 1 (PEPT1) substrate that emits blue fluorescence. D-Ala-Lys-AMCA TFA may be transported into liver cancer cells and Caco-2 cells based on fluorescence analysis. D-Ala-Lys-AMCA TFA can be used for characterizing PEPT1-specific substrates or inhibitors .

HY-P3704

Enterostatin (rat)	Endogenous Metabolite	Metabolic Disease
Enterostatin (rat), an orally active activation peptide of procolipase, selectively reduces fat intake. Enterostatin (rat) reduces serum cholesterol levels by way of a CCK1 receptor-dependent mechanism .

HY-P1142S1

GLP-2(rat) (Ala-13C3,15N) (TFA)	Isotope-Labeled Compounds	Others
GLP-2(rat) (Ala- ¹³C3, ¹⁵N) TFA is ¹³C and ¹⁵N labeled GLP-2(rat) (HY-P1142). GLP-2(rat) is an intestinal growth factor. GLP-2(rat) stimulates cell proliferation and inhibits apoptosis. GLP-2(rat) enhances mucosal mass and function in residual small intestine after massive small bowel resection (MSBR).

HY-P1142S

GLP-2(rat) (Ala-13C3,15N)	Isotope-Labeled Compounds	Others
GLP-2(rat) (Ala- ¹³C3, ¹⁵N) is ¹³C and ¹⁵N labeled GLP-2(rat) (HY-P1142). GLP-2(rat) is an intestinal growth factor. GLP-2(rat) stimulates cell proliferation and inhibits apoptosis. GLP-2(rat) enhances mucosal mass and function in residual small intestine after massive small bowel resection (MSBR).

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-P2818

Alkaline phosphatase, Bovine intestine 1 Publications Verification Apase	Structural Classification Natural Products Animals Classification of Application Fields Source classification Metabolic Disease Disease Research Fields	Endogenous Metabolite
Alkaline phosphatase, Bovine intestine (Apase) is a membrane-bound glycoprotein that catalyzes the hydrolysis of phosphate monoesters at alkaline pH. Alkaline phosphatase can be used in molecular biology and enzyme-free analysis. Inhibition of tissue nonspecific alkaline phosphatase can block intracellular lipid accumulation .

HY-143712

Allolithocholic acid	Structural Classification Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Steroids	Endogenous Metabolite
Allolithocholic acid is a steroid acid could found in normal serum and feces. Allolithocholic acid facilitates excretion, absorption, and transport of fats and sterols in the intestine and liver .

HY-N7387

3-Oxocholic acid	Structural Classification Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Steroids	Endogenous Metabolite
3-Oxocholic acid is an oxo-bile acid metabolite and also a major degradation product from cholic by C. perfringens in the intestine. 3-Oxocholic acid is steroid acid found predominantly in bile of mammals .

HY-B1278

D-α-Tocopherol acetate D-Vitamin E acetate	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite
D-α-Tocopherol acetate (D-Vitamin E acetate) can be hydrolyzed to d-alpha-tocopherol (VE) and absorbed in the small intestine .

HY-N0169

Hyodeoxycholic acid HDCA	Structural Classification Human Gut Microbiota Metabolites Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Steroids	Endogenous Metabolite G protein-coupled Bile Acid Receptor 1
Hyodeoxycholic acid is a secondary bile acid formed in the small intestine by the gut flora, and acts as a TGR5 (GPCR19) agonist, with an EC₅₀ of 31.6 µM in CHO cells.

HY-113529

Stachyose tetrahydrate	Structural Classification Polysaccharides other families Classification of Application Fields Source classification Plants Disease Research Fields Saccharides Cancer	Apoptosis Endogenous Metabolite
Stachyose tetrahydrate, a functional oligosaccharide, acts as a prebiotic. Stachyose tetrahydrate can prevent indirectly colon cancer cell growth by promoting the proliferation of probiotics or producing beneficial materials in the intestine .

HY-N9457

Norcholic acid	Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Steroids	Others
Norcholic acid is a normal minorbile C23 bile acid having four side chain and exsits in human urine and meconium. Norcholic acid can become prominent under certain pathological conditions. Norcholic acid is efficiently absorbed from intestine and quickly excreted into the bile but not into urine .

HY-118103

Coprostanol Coprostan-3-ol	Structural Classification Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields Steroids	Endogenous Metabolite
Coprostanol (Coprostan-3-ol) is a fecal sterol formed by microbial reduction of cholesterol in the intestines of man and higher animals. Coprostanol can be used as an indicator sterol of fecal pollution. Coprostanol has been recognized as a good indicator of pollution of water resources by sewage discharges .

HY-P3003

Cereulide	Microorganisms Source classification	Apoptosis
Cereulide, a toxin depsipeptide, can be produced by Bacillus cereus. Cereulide induces cell apoptosis. Cereulide acts on mitochondria, leading to dysfunction in different organs (liver, pancreatic islet, brain, intestines, etc.) and body systems (immune system and nervous system) .

HY-N10526

Isoglobotriaose Gala-3Galb-4Glc	Structural Classification Natural Products Microorganisms	Others
Isoglobotriaose (Gala-3Galb-4Glc) is a glycosphingolipid found in mammalian tissues. Isoglobotriaose is an analogue of Globotriaose, the ganglioside derivatives of them locate in difference position of small intestine, isoglobotriaosylceramide is restricted to the nonepithelial residue, while globotriaosylceramide is in both compartments .

HY-N3931

Gardneramine	Structural Classification Alkaloids Nepenthes mirabilis (Lour.) Druce Source classification Plants Nepenthaceae	Others
Gardneramine is an orally active alkaloid that acts like papaverine. Gardneramine has peripheral vascular diastolic effect, direct inhibition on myocardium and central inhibition. Gardneramine showed antihypertensive, vasodilatation and atrial inhibition effects in rabbit, dog and guinea pig models, respectively. Gardneramine also inhibits the movement of smooth muscle organs such as the stomach and intestines .

HY-N0142

Phloretin Maximum Cited Publications 16 Publications Verification NSC 407292; RJC 02792	Structural Classification Classification of Application Fields Source classification Rosaceae Plants Dihydrochalcones Endogenous metabolite Human Gut Microbiota Metabolites Flavonoids Microorganisms Malus pumila Mill. Phenols Polyphenols Disease Research Fields Cancer	SGLT Endogenous Metabolite GLUT
Phloretin (NSC 407292; RJC 02792) is a flavonoid extracted from Malus pumila Mill., has anti-inflammatory activities. Phloridzin is a specific, competitive and orally active inhibitor of sodium/glucose cotransporters in the intestine (SGLT1) and kidney (SGLT2). Phloretin inhibits Yeast-made GLUT1 as well as Human erythrocyte GLUT1 with IC₅₀values of 49 μM and 61 μM, respectively .Phloretin has the potential for the treatment of rheumatoid arthritis (RA) and allergic airway inflammation .

HY-N0142R

Phloretin (Standard) NSC 407292 (Standard); RJC 02792 (Standard)	Structural Classification Human Gut Microbiota Metabolites Flavonoids Classification of Application Fields Source classification Malus pumila Mill. Rosaceae Phenols Plants Endogenous metabolite Disease Research Fields Cancer	SGLT Endogenous Metabolite GLUT
Phloretin (Standard) is the analytical standard of Phloretin. This product is intended for research and analytical applications. Phloretin (NSC 407292; RJC 02792) is a flavonoid extracted from Malus pumila Mill., has anti-inflammatory activities. Phloridzin is a specific, competitive and orally active inhibitor of sodium/glucose cotransporters in the intestine (SGLT1) and kidney (SGLT2). Phloretin inhibits Yeast-made GLUT1 as well as Human erythrocyte GLUT1 with IC₅₀values of 49 μM and 61 μM, respectively .Phloretin has the potential for the treatment of rheumatoid arthritis (RA)?and allergic airway inflammation .

Species:	Human (2) Dog (1)
Tag:	His (2) Tag Free (1)
Source:	P. pastoris (1) E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P701972

	Aldose-reductase Protein, Human AKR1B10; Aldo-keto reductase family 1 member B10; ARL-1; Aldose reductase-like; Aldose reductase-related protein; ARP; hARP; Small intestine reductase; SI reductase	Human	E. coli
	The Aldose-reductase protein reduces carbonyl-containing compounds to alcohols, including retinals. It detoxifies unsaturated carbonyls like crotonaldehyde and 4-hydroxynonenal, but lacks reductase activity towards glucose. Aldose-reductase Protein, Human is the recombinant human-derived Aldose-reductase protein, expressed by E. coli , with tag free. The total length of Aldose-reductase Protein, Human is 316 a.a., .

HY-P71714

	Annexin A13/ANXA13 Protein, Dog (P.pastoris, His) ANXA13; ANX13Annexin A13; Annexin XIII; Annexin-13; intestine-specific annexin; ISA	Dog	P. pastoris
	Annexin A13/ANXA13 protein has a high affinity for folic acid and can bind to reduced folic acid derivatives to promote the transport of 5-methyltetrahydrofolate and folic acid analogs into cells. After endocytosis, the FOLR1 protein undergoes conformational changes when exposed to slightly acidic pH, resulting in a significant reduction in its affinity for folate and subsequent release. Annexin A13/ANXA13 Protein, Dog (P.pastoris, His) is the recombinant dog-derived Annexin A13/ANXA13 protein, expressed by P. pastoris , with N-His labeled tag.

HY-P701973

	Aldose-reductase Protein, Human (His) AKR1B10; Aldo-keto reductase family 1 member B10; ARL-1; Aldose reductase-like; Aldose reductase-related protein; ARP; hARP; Small intestine reductase; SI reductase	Human	E. coli
	The Aldose-reductase protein reduces carbonyl-containing compounds to alcohols, including retinals. It detoxifies unsaturated carbonyls like crotonaldehyde and 4-hydroxynonenal, but lacks reductase activity towards glucose. Aldose-reductase Protein, Human (His) is the recombinant human-derived Aldose-reductase protein, expressed by E. coli , with N-6*His labeled tag. The total length of Aldose-reductase Protein, Human (His) is 316 a.a., .

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Species
Source
Tag
Accession
Gene ID
Molecular Weight
Purity
Endotoxin Level
Biological Activity
Appearance
Formulation
Storage & Stability
Shipping
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name	Chemical Structure

HY-B1188S

Propantheline-d3 bromide
Propantheline-d₃ (bromide) is the deuterium labeled Propantheline bromide. Propantheline bromide is an antimuscarinic agent, used for the treatment of hyperhidrosis, cramps or spasms of the stomach, intestines or bladder, and enuresis.

HY-B0310S

Nizatidine-d3
Nizatidine-d₃ is the deuterium labeled Nizatidine. Nizatidine is a potent and orally active histamine H2 receptor antagonist, can be used for the research of stomach and intestines ulcers. Nizatidine works by decreasing the secretion of gastric acid the stomach makes and prevent ulcers from coming back after they have healed in animal models[1].

HY-B1278S1

α-Tocopherol-d6 acetate
α-Tocopherol-d₆ (acetate) is the deuterium labeled D-α-Tocopherol acetate. D-α-Tocopherol acetate (D-Vitamin E acetate) can be hydrolyzed to d-alpha-tocopherol (VE) and absorbed in the small intestine[1].

HY-B0411S

Domperidone-d6
Domperidone-d₆ is the deuterium labeled Domperidone. Domperidone (R33812) is a selective dopamine-2 receptor antagonist. Domperidone acts as an antiemetic and a prokinetic agent through its effects on the chemoreceptor trigger zone and motor function of the stomach and small intestine[1][2].

HY-N0169S

Hyodeoxycholic acid-d5
Hyodeoxycholic acid-d₅ is the deuterium labeled Hyodeoxycholic acid. Hyodeoxycholic acid is a secondary bile acid formed in the small intestine by the gut flora, and acts as a TGR5 (GPCR19) agonist, with an EC50 of 31.6 µM in CHO cells.

HY-P1142S1

GLP-2(rat) (Ala-13C3,15N) (TFA)
GLP-2(rat) (Ala- ¹³C3, ¹⁵N) TFA is ¹³C and ¹⁵N labeled GLP-2(rat) (HY-P1142). GLP-2(rat) is an intestinal growth factor. GLP-2(rat) stimulates cell proliferation and inhibits apoptosis. GLP-2(rat) enhances mucosal mass and function in residual small intestine after massive small bowel resection (MSBR).

HY-P1142S

GLP-2(rat) (Ala-13C3,15N)
GLP-2(rat) (Ala- ¹³C3, ¹⁵N) is ¹³C and ¹⁵N labeled GLP-2(rat) (HY-P1142). GLP-2(rat) is an intestinal growth factor. GLP-2(rat) stimulates cell proliferation and inhibits apoptosis. GLP-2(rat) enhances mucosal mass and function in residual small intestine after massive small bowel resection (MSBR).

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P81368

	AKR1B10 Antibody (YA1113) AKR1B10; AKR1B11; Aldo-keto reductase family 1 member B10; ARL-1; Aldose reductase-like; Aldose reductase-related protein (ARP; hARP); Small intestine reductase (SI reductase)	IHC-P	Human
	AKR1B10 Antibody (YA1113) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1113), targeting AKR1B10. AKR1B10 Antibody (YA1113) can be used for IHC-P experiment in human background.

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Host
Reactivity
Application
Dilution Ratio
Molecular Weight
Conjugation
Clonality
Immunogen
Appearance
Isotype
Gene ID
SwissProt ID
Purity
Formulation
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

intestine

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

NaturalProducts

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Natural
Products