2. GPCR/G Protein Neuronal Signaling Immunology/Inflammation
  3. Histamine Receptor
  4. Nizatidine-d3

Nizatidine-d3 is the deuterium labeled Nizatidine. Nizatidine is a potent and orally active histamine H2 receptor antagonist, can be used for the research of stomach and intestines ulcers. Nizatidine works by decreasing the secretion of gastric acid the stomach makes and prevent ulcers from coming back after they have healed in animal models[1].

For research use only. We do not sell to patients.

Nizatidine-d<sub>3</sub> Chemical Structure

Nizatidine-d3 Chemical Structure

CAS No. : 1246833-99-7

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1 mg USD 200 In-stock
5 mg USD 610 In-stock
10 mg USD 980 In-stock
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100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

Other Forms of Nizatidine-d3:

Nizatidine-d3 Related Antibodies

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H1 Receptor H2 Receptor H3 Receptor H4 Receptor Histamine Receptor

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Nizatidine-d3 is the deuterium labeled Nizatidine. Nizatidine is a potent and orally active histamine H2 receptor antagonist, can be used for the research of stomach and intestines ulcers. Nizatidine works by decreasing the secretion of gastric acid the stomach makes and prevent ulcers from coming back after they have healed in animal models[1].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Nizatidine-d3 Related Antibodies
Molecular Weight

334.48

Formula

C12H18D3N5O2S2
CAS No.
Unlabeled CAS

76963-41-2
Appearance

Solid

Color

White to off-white

SMILES

CN(C)CC1=NC(CSCCN/C(NC([2H])([2H])[2H])=C/[N+]([O-])=O)=CS1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 50 mg/mL (149.49 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMSO : ≥ 50 mg/mL (149.49 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 20 mg/mL (59.79 mM; Need ultrasonic)

H2O : 20 mg/mL (59.79 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9897 mL 14.9486 mL 29.8972 mL
5 mM 0.5979 mL 2.9897 mL 5.9794 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / H2O / DMSO / DMSO 1 mM 2.9897 mL 14.9486 mL 29.8972 mL 74.7429 mL
5 mM 0.5979 mL 2.9897 mL 5.9794 mL 14.9486 mL
10 mM 0.2990 mL 1.4949 mL 2.9897 mL 7.4743 mL
15 mM 0.1993 mL 0.9966 mL 1.9931 mL 4.9829 mL
20 mM 0.1495 mL 0.7474 mL 1.4949 mL 3.7371 mL
25 mM 0.1196 mL 0.5979 mL 1.1959 mL 2.9897 mL
30 mM 0.0997 mL 0.4983 mL 0.9966 mL 2.4914 mL
40 mM 0.0747 mL 0.3737 mL 0.7474 mL 1.8686 mL
50 mM 0.0598 mL 0.2990 mL 0.5979 mL 1.4949 mL
DMSO / DMSO 60 mM 0.0498 mL 0.2491 mL 0.4983 mL 1.2457 mL
80 mM 0.0374 mL 0.1869 mL 0.3737 mL 0.9343 mL
100 mM 0.0299 mL 0.1495 mL 0.2990 mL 0.7474 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Nizatidine-d3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nizatidine-d31246833-99-7Histamine ReceptorInhibitorinhibitorinhibit

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