2. Apoptosis Metabolic Enzyme/Protease
  3. Proteasome Apoptosis
  4. Z-LLY-FMK

Z-LLY-FMK  (Synonyms: Calpain Inhibitor IV)

Cat. No.: HY-136750 Purity: 98.65%
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Z-LLY-FMK (Calpain Inhibitor IV) is a calpain inhibitor, involved in apoptosis of many cell systems. Z-LLY-FMK inhibits the intestine apoptosis after common bile duct ligation.

For research use only. We do not sell to patients.

Z-LLY-FMK Chemical Structure

Z-LLY-FMK Chemical Structure

CAS No. : 133410-84-1

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Based on 1 publication(s) in Google Scholar

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Description

Z-LLY-FMK (Calpain Inhibitor IV) is a calpain inhibitor, involved in apoptosis of many cell systems. Z-LLY-FMK inhibits the intestine apoptosis after common bile duct ligation[1].

IC50 & Target

Calpain[1]
Molecular Weight

557.65

Formula

C30H40FN3O6
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(CF)[C@@H](NC([C@H](CC(C)C)NC([C@H](CC(C)C)NC(OCC1=CC=CC=C1)=O)=O)=O)CC(C=C2)=CC=C2O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (224.15 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7932 mL 8.9662 mL 17.9324 mL
5 mM 0.3586 mL 1.7932 mL 3.5865 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7932 mL 8.9662 mL 17.9324 mL 44.8310 mL
5 mM 0.3586 mL 1.7932 mL 3.5865 mL 8.9662 mL
10 mM 0.1793 mL 0.8966 mL 1.7932 mL 4.4831 mL
15 mM 0.1195 mL 0.5977 mL 1.1955 mL 2.9887 mL
20 mM 0.0897 mL 0.4483 mL 0.8966 mL 2.2415 mL
25 mM 0.0717 mL 0.3586 mL 0.7173 mL 1.7932 mL
30 mM 0.0598 mL 0.2989 mL 0.5977 mL 1.4944 mL
40 mM 0.0448 mL 0.2242 mL 0.4483 mL 1.1208 mL
50 mM 0.0359 mL 0.1793 mL 0.3586 mL 0.8966 mL
60 mM 0.0299 mL 0.1494 mL 0.2989 mL 0.7472 mL
80 mM 0.0224 mL 0.1121 mL 0.2242 mL 0.5604 mL
100 mM 0.0179 mL 0.0897 mL 0.1793 mL 0.4483 mL
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Z-LLY-FMK Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Z-LLY-FMK133410-84-1Calpain Inhibitor IVProteasomeApoptosisInhibitorinhibitorinhibit

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