Phenyl salicylate

Cat. No.: HY-B1731 Purity: 99.98%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Phenyl salicylate (PS) has antibacterial activity when hydrolyzed in small intestine and is often used as nervous system inhibitor and intestinal preservative.

For research use only. We do not sell to patients.

Phenyl salicylate Chemical Structure

CAS No. : 118-55-8

Size	Price	Stock	Quantity
25 g	USD 25	In-stock	Estimated Time of Arrival: December 31
100 g	USD 35	In-stock	Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

Other Forms of Phenyl salicylate:

Phenyl salicylate (Standard) Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Phenyl salicylate (PS) has antibacterial activity when hydrolyzed in small intestine and is often used as nervous system inhibitor and intestinal preservative^[1].

Molecular Weight

214.22

Formula

C₁₃H₁₀O₃

CAS No.

118-55-8

Appearance

Solid

Color

White to off-white

SMILES

O=C(OC1=CC=CC=C1)C2=CC=CC=C2O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

Ethanol : 100 mg/mL (466.81 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.6681 mL	23.3405 mL	46.6810 mL
5 mM	0.9336 mL	4.6681 mL	9.3362 mL
10 mM	0.4668 mL	2.3340 mL	4.6681 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% EtOH 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 5 mg/mL (23.34 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% EtOH 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 5 mg/mL (23.34 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (50.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% EtOH 90% Corn Oil
Solubility: ≥ 5 mg/mL (23.34 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (50.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.98%

Select Batch:

Data Sheet (272 KB) SDS (597 KB)

COA (250 KB) LCMS (94 KB)

Handling Instructions (2659 KB)

References

[1]. Iqbal, M. J., et al. Thermodynamic studies on the interactions of phenyl salicylate in protic solvents at different temperatures. Journal of Molecular Liquids, 143(2–3), 75–80.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

Ethanol	1 mM	4.6681 mL	23.3405 mL	46.6810 mL	116.7025 mL
	5 mM	0.9336 mL	4.6681 mL	9.3362 mL	23.3405 mL
	10 mM	0.4668 mL	2.3340 mL	4.6681 mL	11.6702 mL
	15 mM	0.3112 mL	1.5560 mL	3.1121 mL	7.7802 mL
	20 mM	0.2334 mL	1.1670 mL	2.3340 mL	5.8351 mL
	25 mM	0.1867 mL	0.9336 mL	1.8672 mL	4.6681 mL
	30 mM	0.1556 mL	0.7780 mL	1.5560 mL	3.8901 mL
	40 mM	0.1167 mL	0.5835 mL	1.1670 mL	2.9176 mL
	50 mM	0.0934 mL	0.4668 mL	0.9336 mL	2.3340 mL
	60 mM	0.0778 mL	0.3890 mL	0.7780 mL	1.9450 mL
	80 mM	0.0584 mL	0.2918 mL	0.5835 mL	1.4588 mL
	100 mM	0.0467 mL	0.2334 mL	0.4668 mL	1.1670 mL