2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. JX237

JX237 is an inhibitor of the epithelial neutral amino acid transporter B0AT1 (SLC6A19) with an IC50 value of 31 nM. JX237 is the main transporter for the absorption of neutral amino acids in the intestines and their reabsorption in the kidneys. By inhibiting B0AT1, JX237 can help normalize elevated plasma amino acids in rare amino acid metabolic disorders like phenylketonuria and urea cycle disorders.

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JX237 Chemical Structure

JX237 Chemical Structure

CAS No. : 1021125-90-5

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Description

JX237 is an inhibitor of the epithelial neutral amino acid transporter B0AT1 (SLC6A19) with an IC50 value of 31 nM. JX237 is the main transporter for the absorption of neutral amino acids in the intestines and their reabsorption in the kidneys. By inhibiting B0AT1, JX237 can help normalize elevated plasma amino acids in rare amino acid metabolic disorders like phenylketonuria and urea cycle disorders[1].
Molecular Weight

271.15

Formula

C11H15BrN2O
CAS No.
SMILES

BrC1=C(C)C=C(NCC(NCC)=O)C=C1
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Purity & Documentation
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JX237 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JX2371021125-90-5JX 237JX-237Endogenous MetaboliteSLC6A19amino acid metabolism disorderphenylketonuriaInhibitorinhibitorinhibit

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