2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. JX237

JX237 is an inhibitor of the epithelial neutral amino acid transporter B0AT1 (SLC6A19) with an IC50 value of 31 nM. JX237 is the main transporter for the absorption of neutral amino acids in the intestines and their reabsorption in the kidneys. By inhibiting B0AT1, JX237 can help normalize elevated plasma amino acids in rare amino acid metabolic disorders like phenylketonuria and urea cycle disorders.

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JX237 Chemical Structure

JX237 Chemical Structure

CAS No. : 1021125-90-5

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Description

JX237 is an inhibitor of the epithelial neutral amino acid transporter B0AT1 (SLC6A19) with an IC50 value of 31 nM. JX237 is the main transporter for the absorption of neutral amino acids in the intestines and their reabsorption in the kidneys. By inhibiting B0AT1, JX237 can help normalize elevated plasma amino acids in rare amino acid metabolic disorders like phenylketonuria and urea cycle disorders[1].
Molecular Weight

271.15

Formula

C11H15BrN2O
CAS No.
Appearance

Solid

Color

Yellow to brown

SMILES

BrC1=C(C)C=C(NCC(NCC)=O)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (922.00 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6880 mL 18.4400 mL 36.8800 mL
5 mM 0.7376 mL 3.6880 mL 7.3760 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.6880 mL 18.4400 mL 36.8800 mL 92.1999 mL
5 mM 0.7376 mL 3.6880 mL 7.3760 mL 18.4400 mL
10 mM 0.3688 mL 1.8440 mL 3.6880 mL 9.2200 mL
15 mM 0.2459 mL 1.2293 mL 2.4587 mL 6.1467 mL
20 mM 0.1844 mL 0.9220 mL 1.8440 mL 4.6100 mL
25 mM 0.1475 mL 0.7376 mL 1.4752 mL 3.6880 mL
30 mM 0.1229 mL 0.6147 mL 1.2293 mL 3.0733 mL
40 mM 0.0922 mL 0.4610 mL 0.9220 mL 2.3050 mL
50 mM 0.0738 mL 0.3688 mL 0.7376 mL 1.8440 mL
60 mM 0.0615 mL 0.3073 mL 0.6147 mL 1.5367 mL
80 mM 0.0461 mL 0.2305 mL 0.4610 mL 1.1525 mL
100 mM 0.0369 mL 0.1844 mL 0.3688 mL 0.9220 mL
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JX237 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JX2371021125-90-5JX 237JX-237Endogenous MetaboliteSLC6A19amino acid metabolism disorderphenylketonuriaInhibitorinhibitorinhibit

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