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Results for "

isomerization

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) Endogenous Metabolite (7) Fluorescent Dye (1) HDAC (2) Histone Methyltransferase (2) Lipoxygenase (1) MicroRNA (1) Phosphodiesterase (PDE) (1) Toll-like Receptor (TLR) (1)
By Research Areas:	Cancer (3) Endocrinology (1) Infection (4) Inflammation/Immunology (2) Metabolic Disease (8) Neurological Disease (2)

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Screening Libraries

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Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P2918

Phosphoglucose Isomerase, Rabbit muscle GPI; Phosphoglucose Isomerase	Endogenous Metabolite	Metabolic Disease
Phosphoglucose Isomerase, Rabbit muscle (GPI), i.e., phosphoglucose isomerase/phosphoglucoisomerase (PGI) or phosphohexose isomerase (PHI), is often used in biochemical studies. Glucose 6-phosphate isomeras is a highly conserved glycolytic and dimeric enzyme. Glucose 6-phosphate isomeras catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate .

HY-W027631

cis-2-Butene-1,4-diol	Others	Infection
cis-2-Butene-1,4-diol, an industrial product, can be used for the synthesis of antiviral product oxetanocin A. cis-2-Butene-1,4-diol is a probe for studying isomerization versus hydrogenation and hydrogenolysis reactions .

HY-113478

3β-Ursodeoxycholic acid Isoursodeoxycholic acid	Others	Metabolic Disease
3β-Ursodeoxycholic acid (Isoursodeoxycholic acid) is a bile acid. 3β-Ursodeoxycholic acid shows good tolerance and well intestinal absorption by oral adminstation. 3β-Ursodeoxycholic acid can be isomerized by intestinal and hepatic enzymes to yield UDCA .

HY-19720

Emixustat ACU-4429	Others	Metabolic Disease
Emixustat is an orally active RPE65 inhibitor with an IC₅₀ value of 4.4 nM. Emixustat is also a visual cycle modulator, capable of regulating visual cycle activity by inhibiting retinol isomerization, and holds potential for studying vision disorders such as age-related macular degeneration (AMD) .

HY-P2918A

Phosphoglucose isomerase, bacillus stearothermophilus	Endogenous Metabolite	Metabolic Disease
Phosphoglucose isomerase, bacillus stearothermophilus is a highly conserved glycolytic and dimeric enzyme. Phosphoglucose isomerase, bacillus stearothermophilus catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate .

HY-P2918B

Phosphoglucose isomerase, Baker's Yeast	Endogenous Metabolite	Metabolic Disease
Phosphoglucose isomerase, bacillus stearothermophilus is a highly conserved glycolytic and dimeric enzyme. Phosphoglucose isomerase, bacillus stearothermophilus catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate .

HY-118828A

(9S,13R)-12-Oxo phytodienoic acid (9S,13R)-12-OPDA	Lipoxygenase	Others
9S,13R)-12-Oxo phytodienoic acid is the isomerization of 12-oxo PDA (HY-118828). (9S,13R)-12-Oxo phytodienoic acid is a lipoxygenase metabolite in the leaves of green plants .

HY-W216621

Pinacyanol iodide	Fluorescent Dye	Others
Pinacyanol iodide is a fluorescent cyanine dye. Pinacyanol iodide exhibits ultrafast excited state isomerization .

HY-W753500

(E,E)-9,11-Tetradecadienyl acetate	Others	Endocrinology
(E,E)-9,11-Tetradecadienyl acetate is a female sex pheromone isolated from light-induced isomerization products in female coastal noctuid moths .

HY-W033573

Hexaammineruthenium(II) chloride	Others	Others
Hexaammineruthenium(II) chloride is a yellow crystalline coordination compound with limited solubility in water, serving as a catalyst for various chemical reactions such as hydrogenation, isomerization, and oxidation, while also functioning as a redox probe in electroanalytical methods.

HY-E70022

D-Mannose isomerase (PsMaSeAF)	Others	Others
D-Mannose isomerase (PsMaSeAF) is a carbohydrate isomerase catalyzing the reversible isomerization of d-mannose to d-fructose. D-Mannose isomerase (PsMaSeAF) belongs to the N-acylglucosamine 2-epimerase (AGE) superfamily along with AGE, cellobiose 2-epimerase (CE), and aldose-ketose isomerase (AKI) .

HY-E70308

Glucose isomerase	Endogenous Metabolite	Others
Glucose isomerase is a glucose isomerase that catalyzes the reversible isomerization of D-glucose and D-xylose into D-fructose and D-xylulose, respectively. Glucose isomerase is thermally stable and can be used to produce fructose syrup at high temperatures above 90°C. Glucose isomerase is widely distributed in prokaryotes .

HY-19720A

Emixustat hydrochloride ACU-4429 hydrochloride	Others	Metabolic Disease
Emixustat (ACU-4429) hydrochloride is an orally active RPE65 inhibitor with an IC₅₀ value of 4.4 nM. Emixustat hydrochloride is also a visual cycle modulator, capable of regulating visual cycle activity by inhibiting retinol isomerization, and holds potential for studying vision disorders such as age-related macular degeneration (AMD) .

HY-113465A

11-trans Leukotriene E4	Endogenous Metabolite	Inflammation/Immunology
11-trans Leukotriene E4 is an isomer of Leukotriene E4 (LTE4). Slow isomerization of the C-11 double bond of LTE4 leads to the formation of 11-trans LTE4. 11-trans Leukotriene E4 is equipotent to LTE4 in contracting guinea pig ileum .

HY-117583A

BG47	HDAC Histone Methyltransferase	Neurological Disease
BG47 is a prototypical histone deacetylases HDAC1 and HDAC2 selective, optoepigenetic probe. BG47 can bind to and competitively inhibits the deacetylase activity of HDAC targets upon a light-induced trans-to-cis isomerization, and increases Histone Methyltransferase H3K9 acetylation. BG47 can be used for neurological disease research .

HY-W004500

All-trans-retinal 1 Publications Verification	Endogenous Metabolite Apoptosis	Metabolic Disease
All-trans-retinal is an vitamin A metabolite in the retina, and is produced following photo-isomerization of the visual chromophore 11-cis-Retinal. All-trans-retinal is cleared from photoreceptors by ATP-binding cassette transporter (ABCA4) and all-trans-retinol dehydrogenase (RDH). All-trans-retinal induces Bax activation via DNA damage to mediate retinal cell apoptosis .

HY-P2848

Cholesterol oxidase, Microorganism ChOx	Endogenous Metabolite	Others
Cholesterol oxidase, Microorganism (ChOx) is a bacterial flavin oxidase containing FAD, commonly used in biochemical research. Cholesterol oxidase catalyzes the oxidation of the C(3)-OH group of cholesterol (and other sterols) to cholest-5-en-3-one and isomerizes it to cholest-4-en-3-one .

HY-145344

ONO-8430506	Phosphodiesterase (PDE)	Cancer
ONO-8430506 is an orally bioavailable and potent autotaxin (ATX)/ENPP2 inhibitor with the IC₉₀ of 100 nM for ATX activity in mouse plasma .

HY-117583

cis-BG47	HDAC Histone Methyltransferase	Neurological Disease
cis-BG47 is an cis-isomer of BG47, BG47 is a prototypical histone deacetylases HDAC1 and HDAC2 selective, optoepigenetic probe. BG47 can bind to and competitively inhibits the deacetylase activity of HDAC targets upon a light-induced trans-to-cis isomerization, and increases Histone Methyltransferase H3K9 acetylation. cis-BG47 can be used for neurological disease research .

HY-P2848A

Cholesterol oxidase, rhodococcus sp	Toll-like Receptor (TLR)	Infection Metabolic Disease
Cholesterol oxidase, Rhodococcus sp. is a key enzyme in the cholesterol degradation process. It catalyzes the isomerization and oxidation of cholesterol mediated by the coenzyme FAD. Research indicates that cholesterol oxidase plays a crucial role in the pathogenicity of Mycobacterium tuberculosis by modulating the host macrophage immune response through inhibition of the Toll-like receptor 2 (TLR2) signaling pathway, thereby enhancing the survival of Mycobacterium tuberculosis. Cholesterol oxidase, from Rhodococcus sp., shows potential for research in the field of tuberculosis .

HY-W747563

11-trans Leukotriene D4 11-trans LTD4	Others	Others
11-trans Leukotriene D4 (11-trans LTD4) is a C-11 double bond isomer of LTD4. LTD4 undergoes slow temperature-dependent isomerization to 11-trans LTD4 during storage. 11-trans LTD4 retains about 10-25 % of the potency for contraction of guinea pig ileum, trachea and parenchyma compared to LTD4. It exhibits an ED50 ranging between 12-60 nM for contraction of guinea pig trachea.

HY-118132

LL-Z1220	Others	Infection
LL-Z1220 is a novel antibiotic with the structure of 2-(3,8-dioxopentacyclo[5.1.0.0^~^~]oct-5-en-5-yl)-4H-pyran-4-one. This appears to be the first reported natural product containing a benzene dioxide group. This antibiotic readily undergoes valence isomerization to form 1,4-dioxopentacyclo. The chemical and spectroscopic properties of the antibiotic suggest that the benzene dioxide has a cis configuration.

HY-100072

(2E,4E,6Z)-Methyl deca-2,4,6-trienoate Methyl (2E,4E,6Z)-decatrienoate	Others	Infection
(2E,4E,6Z)-Methyl deca-2,4,6-trienoate (Methyl (2E,4E,6Z)-decatrienoate) is the aggregation pheromone of the brown-winged green bug, Plautia stali. (2E,4E,6Z)-Methyl deca-2,4,6-trienoate exposed to daylight in solutions and/or on dispensers used for field trapping can readily isomerize to form complex mixtures of isomers, thus causing a concern about lure stability and longevity .

HY-116716

PIN1 inhibitor API-1	MicroRNA	Cancer
PIN1 inhibitor API-1 is a specific Pin1 (peptidyl-prolyl cis-trans isomerase NIMA-interacting 1) inhibitor (API-1) with an IC₅₀ of 72.3 nM. PIN1 inhibitor API-1 directly and specifically binds to the Pin1 peptidyl-prolyl isomerase (PPIase) domain and potently inhibits Pin1 cis-trans isomerizing activity. PIN1 inhibitor API-1 retains the active conformation of pXPO5 and restores the ability of pXPO5 to transport pre-miRNAs from nucleus to cytoplasm, thus up-regulating the anticancer miRNA biogenesis to suppress both in vitro and in vivo hepatocellular carcinoma development .

HY-12031B

(2Z,3Z)-U0126	Others	Inflammation/Immunology
(2Z,3Z)-U0126 is a selective inhibitor of MEK1 and MEK2, demonstrating potent antiinflammatory effects by noncompetitively inhibiting AP-1 transcriptional activity with IC50 values of 72 nM for MEK1 and 58 nM for MEK2. (2Z,3Z)-U0126 also inhibits anchorage-independent growth of Ki-ras-transformed rat fibroblasts by blocking both the extracellular signal-regulated kinase and mammalian target of rapamycin pathways. Additionally, (2Z,3Z)-U0126 can undergo isomerization and cyclization, resulting in various products that show reduced affinity for MEK and diminished AP-1 inhibition compared to the parent compound.

HY-N13081

3-Oxo-cinobufagin	Others	Cancer
3-Oxo-cinobufagin (compound 8) is a potential anticancer compound that can be isolated from the broth of M. spinosus by high-performance liquid chromatography. Compared to other isolated compounds, the hydroxyl group at the C-5 position of 3-Oxo-cinobufagin is further oxidized or isomerized, significantly reducing its cytotoxic activity against most cell lines (except HEL), while increasing its activity against the BEL cell line. The IC50 values of 3-Oxo-cinobufagin's cytotoxicity against cancer cells are: 71.3 μM (HepG2), 90.2 μM (SMMC-7221), 0.11 μM (BEL-7402), 72.5 μM (K562), 5.3 μM (HL-60), and 12 nM (HEL) .

HY-N12748

17βH-Gitoxigenin	Others	Others
17βH-Gitoxigenin is a compound that can be isolated from cell suspension cultures of Stropanthus divaricatus .

Cat. No.	Product Name

HY-L098

Drug Metabolite Library	227 compounds
A drug metabolite is a byproduct of the body breaking down, or “metabolizing” a drug into a different substance. Most drugs undergo chemical alteration by various bodily systems as a way to create compounds that are more easily excreted from the body. Drugs can be metabolized by oxidation, reduction, hydrolysis, hydration, conjugation, condensation, or isomerization. Drug metabolism can produce metabolites with physicochemical and pharmacological properties that differ substantially from those of the parent drug, and consequently have important implications for both drug safety and efficacy. MCE offers a unique collection of 227 drug metabolites which is a useful tool for drug safety and efficacy study and drug repurposing.

Drug Metabolite Library

227 compounds

A drug metabolite is a byproduct of the body breaking down, or “metabolizing” a drug into a different substance. Most drugs undergo chemical alteration by various bodily systems as a way to create compounds that are more easily excreted from the body. Drugs can be metabolized by oxidation, reduction, hydrolysis, hydration, conjugation, condensation, or isomerization. Drug metabolism can produce metabolites with physicochemical and pharmacological properties that differ substantially from those of the parent drug, and consequently have important implications for both drug safety and efficacy.

MCE offers a unique collection of 227 drug metabolites which is a useful tool for drug safety and efficacy study and drug repurposing.

Pinacyanol iodide	Fluorescent Dyes/Probes
Pinacyanol iodide is a fluorescent cyanine dye. Pinacyanol iodide exhibits ultrafast excited state isomerization .

All-trans-retinal 1 Publications Verification	Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Terpenoids Source classification Other Diseases Diterpenoids Endogenous metabolite Disease Research Fields	Endogenous Metabolite Apoptosis
All-trans-retinal is an vitamin A metabolite in the retina, and is produced following photo-isomerization of the visual chromophore 11-cis-Retinal. All-trans-retinal is cleared from photoreceptors by ATP-binding cassette transporter (ABCA4) and all-trans-retinol dehydrogenase (RDH). All-trans-retinal induces Bax activation via DNA damage to mediate retinal cell apoptosis .

(9S,13R)-12-Oxo phytodienoic acid (9S,13R)-12-OPDA	Structural Classification Ketones, Aldehydes, Acids Source classification Solanum tuberosum L. Solanaceae Plants	Lipoxygenase
9S,13R)-12-Oxo phytodienoic acid is the isomerization of 12-oxo PDA (HY-118828). (9S,13R)-12-Oxo phytodienoic acid is a lipoxygenase metabolite in the leaves of green plants .

(E,E)-9,11-Tetradecadienyl acetate	Structural Classification Natural Products Animals Source classification	Others
(E,E)-9,11-Tetradecadienyl acetate is a female sex pheromone isolated from light-induced isomerization products in female coastal noctuid moths .

11-trans Leukotriene E4	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Endogenous Metabolite
11-trans Leukotriene E4 is an isomer of Leukotriene E4 (LTE4). Slow isomerization of the C-11 double bond of LTE4 leads to the formation of 11-trans LTE4. 11-trans Leukotriene E4 is equipotent to LTE4 in contracting guinea pig ileum .

3-Oxo-cinobufagin	Structural Classification Microorganisms Source classification Steroids	Others
3-Oxo-cinobufagin (compound 8) is a potential anticancer compound that can be isolated from the broth of M. spinosus by high-performance liquid chromatography. Compared to other isolated compounds, the hydroxyl group at the C-5 position of 3-Oxo-cinobufagin is further oxidized or isomerized, significantly reducing its cytotoxic activity against most cell lines (except HEL), while increasing its activity against the BEL cell line. The IC50 values of 3-Oxo-cinobufagin's cytotoxicity against cancer cells are: 71.3 μM (HepG2), 90.2 μM (SMMC-7221), 0.11 μM (BEL-7402), 72.5 μM (K562), 5.3 μM (HL-60), and 12 nM (HEL) .

17βH-Gitoxigenin	Apocynaceae Structural Classification Natural Products Source classification Strophanthus divaricatus (Lour.) Hook. & Arn. Plants	Others
17βH-Gitoxigenin is a compound that can be isolated from cell suspension cultures of Stropanthus divaricatus .

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