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leukotriene synthesis

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Leukotriene Receptor (10) AP-1 (1) Apoptosis (1) Endogenous Metabolite (4) FLAP (2) Isotope-Labeled Compounds (1) JNK (1) Lipoxygenase (4) Platelet-activating Factor Receptor (PAFR) (1) PROTAC Linkers (4)
By Research Areas:	Cancer (5) Cardiovascular Disease (2) Infection (1) Inflammation/Immunology (13)

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Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Leukotriene Receptor DNA/RNA Synthesis

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-120571

L-674573	Leukotriene Receptor	Cancer
L-674573 is a quinoline *leukotriene* synthesis inhibitor that selectively inhibits 5-lipoxygenase translocation .

HY-107608

Leukotriene B4 1 Publications Verification LTB4; 5(S),12(R)-DiHETE	Endogenous Metabolite PROTAC Linkers Leukotriene Receptor	Inflammation/Immunology Cancer
Leukotriene B4 (LTB4) is known as one of the most potent chemoattractants and activators of leukocytes and is involved in inflammatory diseases. Leukotriene B4 is also an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-107608S

Leukotriene B4-d4 LTB4-d₄; 5(S),12(R)-DiHETE-d₄	PROTAC Linkers Endogenous Metabolite Leukotriene Receptor	Inflammation/Immunology Cancer
Leukotriene B4-d₄ is the deuterium labeled Leukotriene B4. Leukotriene B4 (LTB4) is known as one of the most potent chemoattractants and activators of leukocytes and is involved in inflammatory diseases. Leukotriene B4 is also an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2][3].

HY-107608R

Leukotriene B4 (Standard)	Endogenous Metabolite PROTAC Linkers Leukotriene Receptor	Inflammation/Immunology Cancer
Leukotriene B4 (Standard) is the analytical standard of Leukotriene B4. This product is intended for research and analytical applications. Leukotriene B4 (LTB4) is known as one of the most potent chemoattractants and activators of leukocytes and is involved in inflammatory diseases. Leukotriene B4 is also an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-107608S1

Leukotriene B4-d5 LTB4-d₅	Isotope-Labeled Compounds Endogenous Metabolite PROTAC Linkers Leukotriene Receptor	Inflammation/Immunology Cancer
Leukotriene B4-d₅ (LTB4-d₅) is deuterium labeled Leukotriene B4. Leukotriene B4 (LTB4) is known as one of the most potent chemoattractants and activators of leukocytes and is involved in inflammatory diseases. Leukotriene B4 is also an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-120760

L-691831	Others	Others
L-691831 is a ligand for 5-lipoxygenase activating protein binding assays that has utility as a tool for studying 5-lipoxygenase activating protein (FLAP) related activities. L-691831 can be used to measure the affinity of FLAP on the leukocyte membrane for leukotriene synthesis inhibitors, with binding being correlated with inhibition of leukotriene synthesis.

HY-U00299

LTB4-IN-1	Leukotriene Receptor	Inflammation/Immunology
LTB4-IN-1 (Compound 6) is a **leukotriene synthesis (LTB4) inhibitor with an IC₅₀** of 70 nM .

HY-168015

5-Oxo leukotriene B4	Others	Infection
5-Oxo leukotriene B4 is a byproduct in the synthesis of 12-oxo LTB4 (HY-130497) with antiviral activity. 5-Oxo leukotriene B4 is promising for research of viral infections caused by human and animal enveloped RNA viruses .

HY-106064A

Piriprost potassium U 60257B	Leukotriene Receptor	Inflammation/Immunology
Piriprost (U-60,257B) potassium is an inhibitor of *leukotriene* synthesis. Piriprost potassium inhibits the release of both leukotriene and histamine with an IC₅₀ of 0.11 μM from isolated porcine lung cells. Piriprost potassium increases alkaline phosphatase (ALP) activity in cultured endometrial stromal cells .

HY-113628

ABT-080 VML-530	Leukotriene Receptor	Inflammation/Immunology
ABT-080 is an orally active inhibitor of leukotriene biosynthesis. ABT-080 simultaneously blocks the leukotriene pathways leading to the synthesis of LTB₄ and LTC₄, but does not inhibit PGH2 biosynthesis. ABT-080 can block bronchoconstriction and be used in the research of asthma and related inflammations

HY-112553

HZ52	Lipoxygenase	Inflammation/Immunology
HZ52 is a potent, reversible 5-lipoxygenase inhibitor, blocking leukotriene synthesis with an IC₅₀ of 0.7 μM in intact human polymorphonuclear leukocytes .

HY-118019

Scandenolide	Platelet-activating Factor Receptor (PAFR)	Cardiovascular Disease
Scandenolide is a sesquiterpene lactone that can be found in Philippines medicinal plant Mikania cordata. Scandenolide inhibits leukotriene and platelet activating factor synthesis in leukocytes .

HY-14165

Veliflapon BAY X 1005; DG-031	FLAP Leukotriene Receptor	Cardiovascular Disease Inflammation/Immunology
Veliflapon (BAY X 1005; DG-031) is an orally active and selective 5-lipoxygenase activating protein (FLAP) inhibitor . Veliflapon inhibits the synthesis of the leukotrienes B4 and C4 .

HY-W073687

2,4,6-Triiodophenol	Apoptosis	Others
2,4,6-Triiodophenol is an orally active and potent leukotriene B₄ (LTB₄) *synthesis* inhibitor. 2,4,6-Triiodophenol can induce mouse blastocysts apoptosis .

HY-14460

AM679	FLAP	Inflammation/Immunology
AM679 is a potent, selective 5-lipoxygenase-activating protein (FLAP) inhibitor with an IC₅₀ of 2 nM in a human FLAP membrane binding assay. AM679 markedly reduces the respiratory syncytial virus-driven ocular pathology as well as the synthesis of cysteinyl leukotrienes (CysLTs) in the eye .

HY-113438

15(S)-HPETE	AP-1 JNK	Inflammation/Immunology
15(S)-HPETE is a monohydroperoxy polyunsaturated fatty acid (PUFA) produced by the action of 15-lipoxygenase (15-LO) on arachidonic acid. It is either metabolized to 14,15-leukotriene A41 or reduced to 15(S)-HETE by peroxidases.2,1 15(S)-HpETE mediates a number of biological functions including the induction of c-fos and c-jun, and activation of AP-1.3 15(S)-HpETE inhibits prostacyclin synthesis in porcine aortic microsomes and bovine endothelial cells, and can cause the suicide inactivation of porcine 12-LO.

HY-118848

A63162	Lipoxygenase Leukotriene Receptor	Inflammation/Immunology
A63162 is a specific 5-lipoxygenase (5-LOX) inhibitor. A63162 inhibits mitogen (PHA)-induced horse mononuclear cell (BMC) proliferation and inhibits Calcimycin (HY-N6687)-induced leukotriene LTB4 synthesis at the same concentration. A63162 can be used in the study of chronic obstructive pulmonary disease, arthritis and inflammatory bowel disease .

HY-103158

BW B70C	Lipoxygenase	Others
BW B70C is a potent, selective and orally activearachidonic acid 5-lipoxygenase inhibitor. BW B70C inhibits both acute and allergic bronchoconstriction and late-phase eosinophil accumulation subsequent to allergen inhalation in guinea-pigs. BW B70C prevents leukotriene C4 synthesis and reduces leucocyte migration to the airways lumen as well as albumin microvascular leakage. BW B70C has the potential for the research of anti-asthma agent .

HY-114796

tHGA	Lipoxygenase	Inflammation/Immunology
tHGA is a compound with anti-inflammatory activity and has the activity to inhibit soybean 15-LOX. tHGA showed significant inhibitory effects in experiments on human leukocytes, with an IC₅₀ value of 0.42 μM, which is close to the effect of commonly used standard NDGA. tHGA concentration-dependently inhibits the synthesis of 5-LOX products, especially the cysteine leukotriene LTC(4), with an IC₅₀ value of 1.80 μM. and showed no cytotoxicity. The anti-inflammatory effects of tHGA do not appear to be through redox or metal chelation mechanisms, as the compound was negative in these bioactivity tests. tHGA works through a dual LOX/COX inhibition mechanism and has higher selectivity for 5-LOX and COX-2, with an IC₅₀ value of 0.40 μM .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-107608

Leukotriene B4 1 Publications Verification LTB4; 5(S),12(R)-DiHETE	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease markers Endocrine diseases Nervous System Disorder Endogenous metabolite Inflammation/Immunology Disease Research Fields Cardiovascular System Disorder	Endogenous Metabolite PROTAC Linkers Leukotriene Receptor
Leukotriene B4 (LTB4) is known as one of the most potent chemoattractants and activators of leukocytes and is involved in inflammatory diseases. Leukotriene B4 is also an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-107608R

Leukotriene B4 (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification Disease markers Endocrine diseases Nervous System Disorder Endogenous metabolite Cardiovascular System Disorder	Endogenous Metabolite PROTAC Linkers Leukotriene Receptor
Leukotriene B4 (Standard) is the analytical standard of Leukotriene B4. This product is intended for research and analytical applications. Leukotriene B4 (LTB4) is known as one of the most potent chemoattractants and activators of leukocytes and is involved in inflammatory diseases. Leukotriene B4 is also an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-118019

Scandenolide	Structural Classification Terpenoids Sesquiterpenes Source classification Plants Ballota glandulosissima Hub.-Mor. & Patzak Compositae	Platelet-activating Factor Receptor (PAFR)
Scandenolide is a sesquiterpene lactone that can be found in Philippines medicinal plant Mikania cordata. Scandenolide inhibits leukotriene and platelet activating factor synthesis in leukocytes .

Cat. No.	Product Name	Chemical Structure

HY-107608S

Leukotriene B4-d4
Leukotriene B4-d₄ is the deuterium labeled Leukotriene B4. Leukotriene B4 (LTB4) is known as one of the most potent chemoattractants and activators of leukocytes and is involved in inflammatory diseases. Leukotriene B4 is also an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2][3].

HY-107608S1

Leukotriene B4-d5
Leukotriene B4-d₅ (LTB4-d₅) is deuterium labeled Leukotriene B4. Leukotriene B4 (LTB4) is known as one of the most potent chemoattractants and activators of leukocytes and is involved in inflammatory diseases. Leukotriene B4 is also an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs .

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leukotriene synthesis

Inhibitors & Agonists

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Isotope-Labeled Compounds

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