2,4,6-Triiodophenol

Cat. No.: HY-W073687 Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

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2,4,6-Triiodophenol is an orally active and potent leukotriene B₄ (LTB₄) synthesis inhibitor. 2,4,6-Triiodophenol can induce mouse blastocysts apoptosis.

For research use only. We do not sell to patients.

2,4,6-Triiodophenol Chemical Structure

CAS No. : 609-23-4

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5 mg	USD 50	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 65	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 72	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 90	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 110	In-stock	Estimated Time of Arrival: December 31
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Biological Activity
Purity & Documentation
References
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Description

2,4,6-Triiodophenol is an orally active and potent leukotriene B₄ (LTB₄) synthesis inhibitor. 2,4,6-Triiodophenol can induce mouse blastocysts apoptosis^[1]^[2].

In Vitro

2,4,6-Triiodophenol (5-50 μM; 0-100 h) impairs the quality of pre-implantation mouse embryos in a dose-dependent manner, inducing decline of both total and trophectoderm cell numbers^[2].
2,4,6-Triiodophenol (5?μM; 85 h) shows increasement of apoptotic cells in mouse pre-implantation embryos^[2].
2,4,6-Triiodophenol (5-50?μM; 100 h) induces oxidative stress in mouse pre-implantation embryos^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis^[2]

Cell Line:	Mouse blastocyst cells
Concentration:	5 μM
Incubation Time:	85 hours
Result:	Showed signals of activated Caspase-3/7.

Immunofluorescence^[2]

Cell Line:	Mouse blastocyst cells
Concentration:	5-50 μM
Incubation Time:	100 hours
Result:	Resulted in marked increase of oxygen species (ROS) treated with high dose of 2,4,6-Triiodophenol.

Molecular Weight

471.80

Formula

C₆H₃I₃O

CAS No.

609-23-4

Appearance

Solid

Color

Off-white to pink

SMILES

OC1=C(I)C=C(I)C=C1I

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : 250 mg/mL (529.89 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.1195 mL	10.5977 mL	21.1954 mL
5 mM	0.4239 mL	2.1195 mL	4.2391 mL
10 mM	0.2120 mL	1.0598 mL	2.1195 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.29%

Select Batch:

Data Sheet (273 KB) SDS (393 KB)

COA (248 KB) HNMR (123 KB) RP-HPLC (95 KB)

Handling Instructions (2659 KB)

References

[1]. Liu S, et al. 2,4,6-triiodophenol exhibits embryotoxicity to pre-implantation mouse embryos in an in vitro exposure model. Ecotoxicol Environ Saf. 2022 Aug;241:113745. [Content Brief]

[2]. Trocóniz IF, et al. Dealing with time-dependent pharmacokinetics during the early clinical development of a new leukotriene B4 synthesis inhibitor. Pharm Res. 2006 Jul;23(7):1533-42. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.1195 mL	10.5977 mL	21.1954 mL	52.9886 mL
	5 mM	0.4239 mL	2.1195 mL	4.2391 mL	10.5977 mL
	10 mM	0.2120 mL	1.0598 mL	2.1195 mL	5.2989 mL
	15 mM	0.1413 mL	0.7065 mL	1.4130 mL	3.5326 mL
	20 mM	0.1060 mL	0.5299 mL	1.0598 mL	2.6494 mL
	25 mM	0.0848 mL	0.4239 mL	0.8478 mL	2.1195 mL
	30 mM	0.0707 mL	0.3533 mL	0.7065 mL	1.7663 mL
	40 mM	0.0530 mL	0.2649 mL	0.5299 mL	1.3247 mL
	50 mM	0.0424 mL	0.2120 mL	0.4239 mL	1.0598 mL
	60 mM	0.0353 mL	0.1766 mL	0.3533 mL	0.8831 mL
	80 mM	0.0265 mL	0.1325 mL	0.2649 mL	0.6624 mL
	100 mM	0.0212 mL	0.1060 mL	0.2120 mL	0.5299 mL