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macrophage immune checkpoint

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Area
  • HY-P990061
    Polzastobart

    JTX 8064

    		 Inhibitory Antibodies Inflammation/Immunology Cancer
    Polzastobart (JTX-8064) is a humanized IgG4 monoclonal antagonist antibody that selectively binds LILRB2 and prevents it from binding its ligands, classical and non-classical MHC I molecules. Polzastobart enhances pro-inflammatory cytokine production in macrophages by blocking the ability of LILRB2 to bind HLA-A/B and/or HLA-G, a marker of immunotolerance on cancer cells. Polzastobart is a macrophage immune checkpoint inhibitor .

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