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no cross-resistance

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Bacterial (2) DNA/RNA Synthesis (2) Estrogen Receptor/ERR (1) Fungal (2) Isotope-Labeled Compounds (1) Parasite (3)
By Research Areas:	Cancer (1) Infection (10) Inflammation/Immunology (1)

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Peptides

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: NO Synthase BCRP P-glycoprotein

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-114591

Spiromesifen BSN 2060	Others	Others
Spiromesifen (BSN 2060) is a broad-spectrum tetrachloro acid derivative acaricide. Spiromesifen can interfere with lipid biosynthesis, and has no cross-resistance to any resistant mite or whitefly populations .

HY-133017

Amcenestrant 3 Publications Verification SAR439859	Estrogen Receptor/ERR	Cancer
SAR439859 (compound 43d) is an orally active, nonsteroidal and selective estrogen receptor degrader (SERD). SAR439859 is a potent ER antagonist and has ER degrading activity with an EC₅₀ of 0.2 nM for ERα degradation . SAR439859 demonstrates robust antitumor efficacy and limited cross-resistance in ER ⁺ breast cancer .

HY-126742

MBX-1162	Others	Others
MBX-1162 is a bisindole compound. In the study of its resistance mechanism in Staphylococcus aureus, it did not show cross-resistance with related compounds and was related to the substrate specificity of MepA and MepR.

HY-114591S

Spiromesifen-d9	Isotope-Labeled Compounds	Others
Spiromesifen-d9 is a deuterated labeled Spiromesifen . Spiromesifen (BSN 2060) is a broad-spectrum tetrachloro acid derivative acaricide. Spiromesifen can interfere with lipid biosynthesis, and has no cross-resistance to any resistant mite or whitefly populations .

HY-114591R

Spiromesifen (Standard)	Others	Others
Spiromesifen (Standard) is the analytical standard of Spiromesifen. This product is intended for research and analytical applications. Spiromesifen (BSN 2060) is a broad-spectrum tetrachloro acid derivative acaricide. Spiromesifen can interfere with lipid biosynthesis, and has no cross-resistance to any resistant mite or whitefly populations .

HY-145287

S-MGB-234	DNA/RNA Synthesis Parasite	Infection
S-MGB-234 is a minor groove binder of Animal African Trypanosomiasis (AAT). S-MGB-234 displays excellent in vitro activities against the principal causative organisms of AAT; Trypanosoma congolense, and Trypanosoma vivax. S-MGB-234 does not show cross-resistance with the current diamidine agents and are not internalized via the transporters used by diamidines .

HY-145287A

S-MGB-234 TFA	DNA/RNA Synthesis Parasite	Infection
S-MGB-234 TFA is a minor groove binder used for African Animal Trypanosomiasis (AAT). S-MGB-234 exhibits excellent in vitro activity against the primary pathogens of AAT: Trypanosoma congolense and Trypanosoma vivax. S-MGB-234 TFA does not show cross-resistance with current diamidine active molecules and is not internalized via the transporters used by diamidines .

HY-126576

Dactylocycline A	Others	Infection
Dactylocycline A is a tetracycline derivative with activity against some tetracycline-resistant microorganisms. Dactylocycline A is produced by fermentation of Dactylosporangium sp. and was found to be the most abundant glycoside in the initial fermentation. Dactylocycline A is acid-sensitive and readily hydrolyzes to the common sugar-free core substance dactylocyclinone. Although the sugar-free core has cross-resistance with tetracycline, Dactylocycline A exhibits activity against some tetracycline-resistant microorganisms .

HY-16745A

Lascufloxacin hydrochloride KRP-AM1977 hydrochloride	Others	Infection
Lascufloxacin (KRP-AM1977) hydrochloride is a potent antibacterial compound candidate with broad-spectrum activity against various clinical isolates. Lascufloxacin hydrochloride shows the most potent activity against Gram-positive bacteria compared to other tested quinolones. Lascufloxacin hydrochloride demonstrates incomplete cross-resistance against existing quinolone-resistant strains. Lascufloxacin hydrochloride has potent inhibitory activity against both wild-type and mutated target enzymes.

HY-N12109

Albizziin	Others	Others
Albizziin is an amino acid analog with activity as a competitive inhibitor of asparagine synthetase. Albizziin has been used to isolate Chinese hamster ovary cell mutants with altered levels of the target enzyme. Several mutational classes of albizziin can be distinguished based on cross-resistance to β-aspartic hydroxamic acid. Studies on asparagine synthetase have shown that resistance to albizziin may be associated with altered regulation of asparagine synthetase, structural mutations of the enzyme, and gene amplification .

HY-B0826

Spirodiclofen BAJ-2740	Parasite	Infection
Spirodiclofen is a broad spectrum acaricide acting via lipid biosynthesis inhibition (LBI) with no cross resistance to currently available acaricides and with additional insecticidal properties.

HY-129262

Deoxypheganomycin D	Others	Infection
Deoxypheganomycin D is a specific antimycobacterial inhibitor with activity against the growth of Mycobacterium smegmatis ATCC 607. Deoxypheganomycin D inhibits bacterial growth in a bacteriostatic manner at concentrations up to 7 X 10(-5) M and has no cross-resistance to other antibiotics such as paromomycin, capreomycin, viomycin, streptothricin, kanamycin and streptomycin. Deoxypheganomycin D only partially inhibits the cell growth of M. 607 at 2.8 X 10(-7) M, but has no significant inhibitory effect on DNA, RNA or protein synthesis, while there is a significant reduction in the accumulation of [14C]glycerol-derived radioactive material in the cell wall. Deoxypheganomycin D affects the influx of the amino acid leucine in the presence of 7 X 10(-6) M, while having no effect on the influx of thymidine, whereas the reverse is true for the outflux. The effects of deoxypheganomycin D may be related to cell membrane and specific mycobacterial lipid components .

HY-124408

Mepronil	Fungal	Infection
Mepronil, a compound belonging to the carboxyamine group of fungicides, has a particularly strong bactericidal effect on basidiomycete fungi. Mepronil acts as a single point inhibitor of the succinate ubiquinone reductase or succinate dehydrogenase complex. Mepronil can be used in the study of cross resistance and biological infection .

HY-147017

GSK2556286 GSK286	Bacterial	Infection Inflammation/Immunology
GSK2556286 (GSK286) is an orally active inhibitor of M. tuberculosis. GSK2556286 inhibits growth within human macrophages (IC50 = 0.07 μM). GSK2556286 is effective against both multidrug-resistant (MDR) or extensively drug-resistant (XDR) and agent-sensitive (DS) M. tuberculosis.

HY-124408R

Mepronil (Standard)	Fungal	Infection
Mepronil (Standard) is the analytical standard of Mepronil. This product is intended for research and analytical applications. Mepronil, a compound belonging to the carboxyamine group of fungicides, has a particularly strong bactericidal effect on basidiomycete fungi. Mepronil acts as a single point inhibitor of the succinate ubiquinone reductase or succinate dehydrogenase complex. Mepronil can be used in the study of cross resistance and biological infection .

HY-P3350

LS-BF1	Bacterial	Infection
LS-BF1 is a stable and low toxic cationic antimicrobial peptide. LS-BF1 displays broad spectrum of antibacterial activity, including the challenging ESKAPE pathogens, by cell membrane disruptive mechanism. LS-BF1 shows good in vivo efficacy for elimination of bacteria in a mouse infection model[1].

Cat. No.	Product Name	Target	Research Area

HY-P3350

LS-BF1	Bacterial	Infection
LS-BF1 is a stable and low toxic cationic antimicrobial peptide. LS-BF1 displays broad spectrum of antibacterial activity, including the challenging ESKAPE pathogens, by cell membrane disruptive mechanism. LS-BF1 shows good in vivo efficacy for elimination of bacteria in a mouse infection model[1].

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-126576

Dactylocycline A	Structural Classification Microorganisms Antibiotics Source classification	Others
Dactylocycline A is a tetracycline derivative with activity against some tetracycline-resistant microorganisms. Dactylocycline A is produced by fermentation of Dactylosporangium sp. and was found to be the most abundant glycoside in the initial fermentation. Dactylocycline A is acid-sensitive and readily hydrolyzes to the common sugar-free core substance dactylocyclinone. Although the sugar-free core has cross-resistance with tetracycline, Dactylocycline A exhibits activity against some tetracycline-resistant microorganisms .

HY-N12109

Albizziin	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification	Others
Albizziin is an amino acid analog with activity as a competitive inhibitor of asparagine synthetase. Albizziin has been used to isolate Chinese hamster ovary cell mutants with altered levels of the target enzyme. Several mutational classes of albizziin can be distinguished based on cross-resistance to β-aspartic hydroxamic acid. Studies on asparagine synthetase have shown that resistance to albizziin may be associated with altered regulation of asparagine synthetase, structural mutations of the enzyme, and gene amplification .

Cat. No.	Product Name	Chemical Structure

HY-114591S

Spiromesifen-d9
Spiromesifen-d9 is a deuterated labeled Spiromesifen . Spiromesifen (BSN 2060) is a broad-spectrum tetrachloro acid derivative acaricide. Spiromesifen can interfere with lipid biosynthesis, and has no cross-resistance to any resistant mite or whitefly populations .

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no cross-resistance

Inhibitors & Agonists

Peptides

NaturalProducts

Isotope-Labeled Compounds

Natural
Products