nonsense

By Targets:	Amino Acid Derivatives (1) Apoptosis (1) Autophagy (2) Bcl-2 Family (1) Biochemical Assay Reagents (1) CFTR (3) Eukaryotic Initiation Factor (eIF) (1)
By Research Areas:	Cancer (9) Inflammation/Immunology (1) Metabolic Disease (6)
Oligonucleotides:	Antisense Oligonucleotides (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W009912

H-Tyr(Me)-OH	Amino Acid Derivatives	Others
H-Tyr(Me)-OH is a synthetic amino acid, and can enter into protein in E. coli in response to an amber nonsense codon .

HY-118341

Clitocine	Apoptosis Bcl-2 Family	Cancer
Clitocine, an adenosine nucleoside analog isolated from mushroom, is a potent and efficacious readthrough agent. Clitocine acts as a suppressor of nonsense mutations and can induce the production of p53 protein in cells harboring p53 nonsense-mutated alleles. Clitocine can induce apoptosis in multidrug-resistant human cancer cells by targeting Mcl-1. Anticancer activity .

HY-114231B

Exaluren disulfate 1 Publications Verification ELX-02 disulfate; NB-124 disulfate	Others	Metabolic Disease
Exaluren (ELX-02) disulfate is an investigational, advanced synthetic eukaryotic ribosome selective glycoside (ERSG). Exaluren disulfate is being developed as a therapy for genetic diseases caused by nonsense mutations .

HY-14832

Ataluren Maximum Cited Publications 7 Publications Verification PTC124	CFTR Autophagy	Metabolic Disease Cancer
Ataluren (PTC124) is an orally available CFTR-G542X nonsense allele inhibitor.

HY-161111

KVS0001	Others	Cancer
KVS0001 is a potent inhibitor of SMG1 and nonsense mediated decay (NMD) that has anti-tumor activity .

HY-111374

NMDI14 3 Publications Verification	Others	Cancer
NMDI14 is a nonsense mediated RNA decay (NMD) inhibitor. NMDI14 disrupts the SMG7-UPF1 interactions and inhibits NMD.

HY-101203

GJ103	Others	Metabolic Disease Cancer
GJ103 is a read-through compound that can induce read through of premature stop codons. GJ103 has potential for the research of genetic disorders caused by nonsense mutations .

HY-114231C

Exaluren sulfate ELX-02 sulfate; NB-124 sulfate	Others	Metabolic Disease
Exaluren (ELX-02) sulfate is an investigational, advanced synthetic eukaryotic ribosome selective glycoside (ERSG). Exaluren sulfate is being developed as a therapy for genetic diseases caused by nonsense mutations .

HY-114231

Exaluren ELX-02; NB-124	Others	Others
Exaluren (ELX-02) is an synthetic eukaryotic ribosome-selective glycoside that induces read through of nonsense mutations, resulting in normally localized full-length functional proteins. Exaluren is used for the research of cystic fibrosis caused by nonsense mutations .

HY-123359

RTC14	Others	Others
RTC14 is a read-through compound (RTC) that can induce ribosomes to bypass nonsense mutations in mRNA and allow the production of full-length functional proteins. RTC14 has the potential to be used in the research of various genetic disorders, such as nonsense mutations in the ataxia-telangiectasia mutated (ATM) gene and the dystrophin gene .

HY-101203A

GJ103 sodium 1 Publications Verification	Others	Metabolic Disease Cancer
GJ103 sodium is a read-through compound that can induce read through of premature stop codons. GJ103 sodium has potential for the research of genetic disorders caused by nonsense mutations .

HY-14832R

Ataluren (Standard)	CFTR Autophagy	Metabolic Disease Cancer
Ataluren (Standard) is the analytical standard of Ataluren. This product is intended for research and analytical applications. Ataluren (PTC124) is an orally available CFTR-G542X nonsense allele inhibitor.

HY-126210

GJ072	Biochemical Assay Reagents	Others
GJ072 is a read-through compound (RTCs). GJ072 can induce “readthrough” .

HY-157468

(R)-ELX-02	Others	Others
(R)-ELX-02, also referred to as NB-124, is an eukaryotic ribosomal selective glycoside (ERSG) engineered to enhance read-through activity in patients with nonsense mutations, facilitating the generation of adequate levels of full-length functional protein.

HY-150089

SRI-37240	CFTR	Inflammation/Immunology
SRI-37240 is a potent premature termination codons (PTCs) inhibitor. SRI-37240 suppresses CFTR nonsense mutations. SRI-37240 alters cellular translation termination at PTCs in HEK293T cells. SRI-37240 can also restore CFTR function in primary bronchial epithelial cells when combination with G418 .

HY-101513

eIF4A3-IN-1 3 Publications Verification	Eukaryotic Initiation Factor (eIF)	Cancer
eIF4A3-IN-1 (compound 53a) is a selective eukaryotic initiation factor 4A3 (eIF4A3) inhibitor (IC₅₀=0.26 μM; K_d=0.043 μM), which binds to a non-ATP binding site of eIF4A3 and shows significant cellular nonsense-mediated RNA decay (NMD) inhibition at 10 and 3 μM and can be as a probe for further study of eIF4A3, the exon junction complex (EJC), and NMD .

Cat. No.	Product Name	Target	Research Area

HY-W009912

H-Tyr(Me)-OH	Amino Acid Derivatives	Others
H-Tyr(Me)-OH is a synthetic amino acid, and can enter into protein in E. coli in response to an amber nonsense codon .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-118341

Clitocine	Alkaloids Structural Classification Microorganisms Classification of Application Fields Other Alkaloids Source classification Disease Research Fields Cancer	Apoptosis Bcl-2 Family
Clitocine, an adenosine nucleoside analog isolated from mushroom, is a potent and efficacious readthrough agent. Clitocine acts as a suppressor of nonsense mutations and can induce the production of p53 protein in cells harboring p53 nonsense-mutated alleles. Clitocine can induce apoptosis in multidrug-resistant human cancer cells by targeting Mcl-1. Anticancer activity .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P82113

	RENT1 Antibody (YA1858) UPF1; KIAA0221; RENT1; Regulator of nonsense transcripts 1; ATP-dependent helicase RENT1; nonsense mRNA reducing factor 1; NORF1; Up-frameshift suppressor 1 homolog; hUpf1	WB, IHC-F, IHC-P, ICC/IF, IP	Human
	RENT1 Antibody (YA1858) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1858), targeting RENT1, with a predicted molecular weight of 124 kDa (observed band size: 124 kDa). RENT1 Antibody (YA1858) can be used for WB, IHC-F, IHC-P, ICC/IF, IP experiment in human background.

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Cat. No.	Product Name		Classification

HY-158830

MDM4-targeting ASO sodium		Antisense Oligonucleotides
MDM4-targeting ASO sodium is a 25mer antisense oligonucleotide targeting?MDM4. MDM4-targeting ASO sodium induced exon 6 skipping, leading to nonsense-mediated decay of the mRNA transcript that excludes exon-6. In multiple human melanoma cell lines and in melanoma patient-derived xenograft (PDX) mouse models, MDM4-targeting ASO-mediated skipping of exon 6 decreased MDM4 abundance, inhibited melanoma growth, and enhanced sensitivity to MAPK-targeting therapeutics.

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