pRb

By Targets:	Apoptosis (1) c-Myc (2) CDK (5) FLT3 (1) JAK (1) Molecular Glues (2) Progesterone Receptor (3) PROTACs (2) Small Interfering RNA (siRNA) (4)
By Research Areas:	Cancer (8) Endocrinology (3)
Oligonucleotides:	Pre-designed siRNA Sets (4) siRNAs (4)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-158106

AZD8421	CDK	Cancer
AZD8421 is a selective CDK2 inhibitor (IC₅₀: 9 nM) with selectivity for CDK1, CDK4 and CDK6. AZD8421 inhibits cancer cell proliferation by inhibiting pRB phosphorylation, inducing cell cycle arrest and senescence. AZD8421 demonstrated promising single efficacy and synergy with CDK4/6 inhibitors such as Palbociclib (HY-50767) in in vivo breast and ovarian models. AZD8421 also has potent single-agent inhibitory activity against drug-resistant breast cancer cells.

HY-162318

MYC degrader 1	Molecular Glues c-Myc	Cancer
MYC degrader 1 (compound A80.2HCl) is an orally available MYC molecular glues degrader with anti-tumor activity. MYC degrader 1 restores pRB1 protein activity and re-establishes sensitivity of MYC overexpressing cancer cells to CDK4/6 inhibitors .

HY-162318A

MYC degrader 1 TFA	Molecular Glues c-Myc	Cancer
MYC degrader 1 TFA (compound A80.2HCl) is an orally available MYC molecular glues degrader with anti-tumor activity. MYC degrader 1 TFA restores pRB1 protein activity and re-establishes sensitivity of MYC overexpressing cancer cells to CDK4/6 inhibitors .

HY-RS11051

PRB1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
PRB1 Human Pre-designed siRNA Set A contains three designed siRNAs for PRB1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PRB1 Human Pre-designed siRNA Set A PRB1 Human Pre-designed siRNA Set A

HY-RS11052

PRB2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
PRB2 Human Pre-designed siRNA Set A contains three designed siRNAs for PRB2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PRB2 Human Pre-designed siRNA Set A PRB2 Human Pre-designed siRNA Set A

HY-RS11053

PRB3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
PRB3 Human Pre-designed siRNA Set A contains three designed siRNAs for PRB3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PRB3 Human Pre-designed siRNA Set A PRB3 Human Pre-designed siRNA Set A

HY-RS11054

PRB4 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
PRB4 Human Pre-designed siRNA Set A contains three designed siRNAs for PRB4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PRB4 Human Pre-designed siRNA Set A PRB4 Human Pre-designed siRNA Set A

HY-147220

Dexamethasone oxetanone Dex-Ox	Progesterone Receptor	Endocrinology
Dexamethasone oxetanone (Dex-Ox), a derivative of the glucocorticoid-selective steroid Dexamethasone (Dex), is an antiglucocorticoid. Dexamethasone oxetanone is an antiprogestin with significant agonist activity with progesterone receptor (PR) A and B isoforms .

HY-118257

Org-31710	Progesterone Receptor	Endocrinology Cancer
Org-31710 is a specific progesterone receptor (PR) inhibitor. Org-31710 shows antiprogestational effect. Org 31710 abolishes the Folic acid (HY-16637)-regulated proliferation and migration in PR positive cancer cell lines. Org 31710 abolishes the folic acid-increased the levels of p-PRA, p-PRB, and p-cSrcY416 .

HY-16290

Lonaprisan ZK 230211; BAY86 5044	Progesterone Receptor	Endocrinology
Lonaprisan (ZK 230211; BAY86 5044) is an antagonist for progesterone receptor, with IC₅₀ of 3.6 pM and 2.5 pM for PR-A and PR-B, respectively. Lonaprisan exhibits antiprogestagenic activity in rabbits, interrupts early pregnancy in rats, and exhibits antitumor efficacy against DMBA (HY-W011845)-induced mammary tumor. Lonaprisan reveals antiglucocorticoid and antiandrogenic effect .

HY-129180

XY028-133	PROTACs CDK	Cancer
XY028-133 (example 14) is a PROTAC-based CDK4/6 degrader with anti-tumor activity, which consists of ligands for von Hippel-Lindau and CDK .

HY-15166

(E/Z)-Zotiraciclib 5 Publications Verification (E/Z)-TG02; (E/Z)-SB1317	CDK JAK FLT3	Cancer
(E/Z)-Zotiraciclib ((E/Z)-TG02) is a potent inhibitor of CDK2, JAK2 and FLT3 with IC₅₀s of 13, 73 and 56 nM, respectively. (E/Z)-Zotiraciclib effectively inhibits the proliferation of cancer cells, it can be used for the research of cancer .

HY-168660

CPD-10	PROTACs Apoptosis CDK	Cancer
CPD-10 is a potent CCND1 and CDK4 PROTAC degrader. CPD-10 shows anti-proliferation. CPD-10 induces apoptosis. CPD-10 decreases the protein expression of cyclin D1, cyclin D3, CDK4, P-Rb(5807/811) in a dose-dependent manner. (Pink: ligand for target protein (HY-50767); black: linker (HY-22391); Blue: E3 ligase ligand (HY-168667)) .

HY-136726

CGP-82996 CINK4	CDK	Cancer
GP-82996 (CINK4) is a pharmacological inhibitor of CDK4/6. GP-82996 has IC₅₀s of 1.5, 5.6 and 25 μM for CDK4/cyclin D1, CDK6/cyclin D1 and Cdk5/p35, respectively. GP-82996 induces the apoptosis of cancer cells U2OS. GP-82996 can be used in the research of cancer .

Cat. No.	Product Name

HY-L201

Cell Proliferation Compound Library	2,332 compounds
Cell proliferation, the increase in cell numbers resulting from cell division, is a complex and tightly regulated process. Cell proliferation is regulated by coordinated entry into the cell cycle, and changes in proliferation are closely linked to disease development. Evolutionary dynamics links tumor growth and progression with cell proliferation, cell death, and mutation rates. In addition, cell proliferation is central to degenerative diseases, the development of which is often accompanied by accelerated multiplication of cancer cells. Therefore, assays of cell proliferation levels are frequently used for laboratory research purposes and increasingly for clinical assessment of tumor aggressiveness and potentially to guide care. It has been shown that multiple key targets are collectively involved in regulating the process of cell proliferation, such as CDK, E2F, pRB, β-Catenin, and others. MCE collects 2,332 compounds that target and regulate key targets of cell proliferation, which can be used in studies of cell proliferation mechanisms and drug discovery.

Cell Proliferation Compound Library

2,332 compounds

Cell proliferation, the increase in cell numbers resulting from cell division, is a complex and tightly regulated process. Cell proliferation is regulated by coordinated entry into the cell cycle, and changes in proliferation are closely linked to disease development. Evolutionary dynamics links tumor growth and progression with cell proliferation, cell death, and mutation rates. In addition, cell proliferation is central to degenerative diseases, the development of which is often accompanied by accelerated multiplication of cancer cells. Therefore, assays of cell proliferation levels are frequently used for laboratory research purposes and increasingly for clinical assessment of tumor aggressiveness and potentially to guide care. It has been shown that multiple key targets are collectively involved in regulating the process of cell proliferation, such as CDK, E2F, pRB, β-Catenin, and others.

MCE collects 2,332 compounds that target and regulate key targets of cell proliferation, which can be used in studies of cell proliferation mechanisms and drug discovery.

Species:	Human (2)
Tag:	Strep (1) GST (1)
Source:	E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P702946

	RB1 Protein, Human (GST) Retinoblastoma-associated protein; p105-Rb; p110-RB1; pRb (Rb); pp110; RB1	Human	E. coli
	RB1 Protein, Human (GST) is the recombinant human-derived RB1, expressed by E. coli , with GST labeled tag. ,

HY-P703588

	RB1 Protein, Human (StrepⅡ) Retinoblastoma-associated protein; p105-Rb; p110-RB1; pRb; Rb; pp110; RB1; Homo sapiens; Human; Rb; Chromatin regulator; DNA-binding; Repressor	Human	E. coli
	RB1 Protein, Human (Strep) is the recombinant human-derived RB1, expressed by E. coli , with Strep labeled tag. ,

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Cat. No.	Compare	Product Name	Application	Reactivity

HY-P81301

	Phospho-Rb (Thr356) Antibody (YA1029) RB1; Retinoblastoma-associated protein; p105-Rb; pRb; Rb; pp110	WB, IHC-P, IP	Human, Rat
	Phospho-Rb (Thr356) Antibody (YA1029) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1029), targeting Phospho-Rb (Thr356), with a predicted molecular weight of 106 kDa (observed band size: 110 kDa). Phospho-Rb (Thr356) Antibody (YA1029) can be used for WB, IHC-P, IP experiment in human, rat background.

HY-P81301A

	Phospho-Rb (Ser780) Antibody (YA1030) RB1; Retinoblastoma-associated protein; p105-Rb; pRb; Rb; pp110	WB, IP	Human, Rat
	Phospho-Rb (Ser780) Antibody (YA1030) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1030), targeting Phospho-Rb (Ser780), with a predicted molecular weight of 106 kDa (observed band size: 110 kDa). Phospho-Rb (Ser780) Antibody (YA1030) can be used for WB, IP experiment in human, rat background.

HY-P81301B

	Phospho-Rb (Ser811) Antibody (YA1031) RB1; Retinoblastoma-associated protein; p105-Rb; pRb; Rb; pp110	WB	Human, Hamster
	Phospho-Rb (Ser811) Antibody (YA1031) is a biotin-conjugated non-conjugated IgG antibody, targeting Phospho-Rb (Ser811), with a predicted molecular weight of 106 kDa (observed band size: 110 kDa). Phospho-Rb (Ser811) Antibody (YA1031) can be used for WB experiment in human, hamster background.

HY-P81301C

	Phospho-Rb (Ser608) Antibody (YA1032) RB1; Retinoblastoma-associated protein; p105-Rb; pRb; Rb; pp110	WB, IHC-P	Human, Rat
	Phospho-Rb (Ser608) Antibody (YA1032) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1032), targeting Phospho-Rb (Ser608), with a predicted molecular weight of 106 kDa (observed band size: 110 kDa). Phospho-Rb (Ser608) Antibody (YA1032) can be used for WB, IHC-P experiment in human, rat background.

HY-P81301D

	Phospho-Rb (Thr252) Antibody (YA1033) RB1; Retinoblastoma-associated protein; p105-Rb; pRb; Rb; pp110	WB, IHC-P	Human, Rat
	Phospho-Rb (Thr252) Antibody (YA1033) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1033), targeting Phospho-Rb (Thr252), with a predicted molecular weight of 106 kDa (observed band size: 110 kDa). Phospho-Rb (Thr252) Antibody (YA1033) can be used for WB, IHC-P experiment in human, rat background.

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Cat. No.	Product Name		Classification

HY-RS11051

PRB1 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
PRB1 Human Pre-designed siRNA Set A contains three designed siRNAs for PRB1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS11052

PRB2 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
PRB2 Human Pre-designed siRNA Set A contains three designed siRNAs for PRB2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS11053

PRB3 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
PRB3 Human Pre-designed siRNA Set A contains three designed siRNAs for PRB3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS11054

PRB4 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
PRB4 Human Pre-designed siRNA Set A contains three designed siRNAs for PRB4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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