2. PI3K/Akt/mTOR Protein Tyrosine Kinase/RTK Cell Cycle/DNA Damage Apoptosis Metabolic Enzyme/Protease
  3. Akt PI3K Anaplastic lymphoma kinase (ALK) CDK Apoptosis Mitochondrial Metabolism
  4. ALK/PI3K/AKT-IN-1

ALK/PI3K/AKT-IN-1 (Compound 45) inhibits the proliferation of cancer cell A549, H1975 and PC9 with an IC50 of 0.44, 0.83 and 1.51 μM. ALK/PI3K/AKT-IN-1 increases the expression of p21 and p27, inhibits the activity of CDK2 and p-Rb, arrests the cell cycle at G1 phase. ALK/PI3K/AKT-IN-1 inhibits the ALK/PI3K/AKT signaling pathway, promotes the depolarization of mitochondrial membrane potential, and inducing apoptosis in A549 cell. ALK/PI3K/AKT-IN-1 inhibits the formation and growth of A549 cell spheroids.

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ALK/PI3K/AKT-IN-1 Chemical Structure

ALK/PI3K/AKT-IN-1 Chemical Structure

CAS No. : 3050831-84-7

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ALK/PI3K/AKT-IN-1 Related Antibodies

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Akt Akt1 Akt2 Akt3

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PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

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CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85

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Description

ALK/PI3K/AKT-IN-1 (Compound 45) inhibits the proliferation of cancer cell A549, H1975 and PC9 with an IC50 of 0.44, 0.83 and 1.51 μM. ALK/PI3K/AKT-IN-1 increases the expression of p21 and p27, inhibits the activity of CDK2 and p-Rb, arrests the cell cycle at G1 phase. ALK/PI3K/AKT-IN-1 inhibits the ALK/PI3K/AKT signaling pathway, promotes the depolarization of mitochondrial membrane potential, and inducing apoptosis in A549 cell. ALK/PI3K/AKT-IN-1 inhibits the formation and growth of A549 cell spheroids[1].

Molecular Weight

473.52

Formula

C25H20FN5O2S
CAS No.
SMILES

O=C(NC1=NC2=CC(C3=CC4=C(N=CN(CCC)C4=O)C=C3)=CC=C2S1)NC5=CC=C(F)C=C5
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ALK/PI3K/AKT-IN-1 Related Classifications

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  • Do most proteins show cross-species activity?

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Keywords:

ALK/PI3K/AKT-IN-13050831-84-7AktPI3KAnaplastic lymphoma kinase (ALK)CDKApoptosisMitochondrial MetabolismPKBProtein kinase BPhosphoinositide 3-kinaseAnaplastic lymphoma kinaseALK tyrosine kinase receptorCD246Cluster of differentiation 246Cyclin dependent kinaseH1975A549PC9Inhibitorinhibitorinhibit

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