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site-specific

" in MedChemExpress (MCE) Product Catalog:

30

Inhibitors & Agonists

1

Fluorescent Dye

3

Peptides

2

Inhibitory Antibodies

4

Click Chemistry

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-145576B
    2-Amino-8-oxononanoic acid hydrochloride

    		Fluorescent Dye Others
    2-Amino-8-oxononanoic acid (hydrochloride) is the hydrochloride form of 2-Amino-8-oxononanoic acid. 2-Amino-8-oxononanoic acid is an amino acid, incorporation into proteins in E.coli in genetic. 2-Amino-8-oxononanoic acid is efficient in labeling of proteins with different probes with a site-specific manner under a mild condition close to the physiological pH .
    2-Amino-8-oxononanoic acid hydrochloride
  • HY-135140
    Methyltetrazine-Amine

    		Drug Intermediate Others
    Methyltetrazine-Amine, a tetrazine compound, is used for the site-specific dual functionalization of the resulting bioconjugates .
    Methyltetrazine-Amine
  • HY-135140A
    Methyltetrazine-amine hydrochloride

    		Others Others
    Methyltetrazine-Amine, a tetrazine compound, is used for the site-specific dual functionalization of the resulting bioconjugates .
    Methyltetrazine-amine hydrochloride
  • HY-133870
    Itaconate-alkyne
    2 Publications Verification

    ITalk

    		 Fluorescent Dye Inflammation/Immunology
    Itaconate-alkyne (ITalk) is a specific bioorthogonal probe for quantitative and site-specific chemoproteomic profiling of Itaconation in living cells. Itaconate-alkyne, a functional analogue of Itaconate, exhibits comparable antiinflammatory effect with Itaconate and enables the labeling of bona fide targets of Itaconate . Itaconate-alkyne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Itaconate-alkyne
  • HY-126054
    A1062

    		Others Others
    A1062 is an inhibitor for Tn3 encoded resolvase with IC50 in micromolar level. A1062 suppresses the binding of resolvase proteins to res sites, and blocks resolvase-induced site-specific recombination .
    A1062
  • HY-145576
    2-Amino-8-oxononanoic acid

    		Fluorescent Dye Others
    2-Amino-8-oxononanoic acid is an amino acid, incorporation into proteins in E.coli in genetic. 2-Amino-8-oxononanoic acid is efficient in labeling of proteins with different probes with a site-specific manner under a mild condition close to the physiological pH .
    2-Amino-8-oxononanoic acid
  • HY-114684
    A20832

    		Topoisomerase Others
    A20832 is a specific resolvase inhibitor that blocks both the recombination and topoisomerase activities of resolvase. A20832 inhibits the site-specific recombination reaction mediated by the Tn3-encoded resolvase protein at the strand cleavage step and has no effect on synapsis .
    A20832
  • HY-Y1422B
    Lipase (MS grade)

    		Endogenous Metabolite Metabolic Disease
    Lipase (MS grade) catalyzes the hydrolysis of triacylglycerols to release long-chain fatty acids in a site-specific manner.
    Lipase (MS grade)
  • HY-W414321
    Fructosamine hydrochloride

    D-Isoglucosamine hydrochloride

    		 Endogenous Metabolite Others
    Fructosamine hydrochloride (D-Isoglucosamine hydrochloride) is a metabolic intermediate and component of cell membranes and cartilage. Fructosamine hydrochloride induces site-specific breaks in DNA chains, especially in the presence of Cu 2+ .
    Fructosamine hydrochloride
  • HY-161762
    RA-0002034

    		Virus Protease Infection
    RA-0002034 is a Chikungunya virus (CHIKV) nsP2 protease inhibitor with an IC50 of 58 nM. RA-0002034 covalently modifies the catalytic cysteine in a site-specific manner .
    RA-0002034
  • HY-161762A
    (E/Z)-RA-0002034

    		Influenza Virus Cancer
    (E/Z)-RA-0002034 is a Chikungunya virus (CHIKV) nsP2 protease inhibitor with IC50 of 58 nM. RA-0002034 covalently modifies the catalytic cysteine in a site-specific manner.
    (E/Z)-RA-0002034
  • HY-148426
    OSu-PEG4-VC-PAB-MMAE

    		Drug-Linker Conjugates for ADC Others
    OSu-PEG4-VC-PAB-MMAE involves in GDP-FAmP4MMAE (Monomethylauristatin E) synthesis, which is for GDP label via site-specific conjugation .
    OSu-PEG4-VC-PAB-MMAE
  • HY-160607
    MMA-NODAGA

    		Radionuclide-Drug Conjugates (RDCs) Others
    MMA-NODAGA is a chelator for site-specific labeling of targeting proteins containing unpaired cysteine. MMA-NODAGA can be used to conjugate with exosome and 64Cu in image with positron emission tomography (PET) <[2].
    MMA-NODAGA
  • HY-P99238
    Rolinsatamab

    		ADC Antibody Inflammation/Immunology Cancer
    Rolinsatamab is a IgG1κ type chimeric antibody targeting to PRLR (prolactin receptor). Rolinsatamab can be conjugated with pyrrolobenzodiazepine (PDB) dimer SGD-1882 (HY-101127) via a cleavable maleimidocaproyl type linker, to form an antibody-drug conjugate, Rolinsatamab talirine. One Rolinsatamab talirine has an average of 2 site-specific drug attachment engineered cysteines (S239C). The linker equips the valine-alanine dipeptide, as cathepsine B cleavage site. on an average of 2 site-specific drug attachment engineered cysteines (S239C) .
    Rolinsatamab
  • HY-E70128
    Leucyl aminopeptidase

    		Others Others
    Leucyl aminopeptidase is a metallopeptidase that cleave N-terminal residues from proteins and peptides. Leucyl aminopeptidase serves as transcriptional repressors to control pyrimidine, alginate and cholera toxin biosynthesis, as well as mediate site-specific recombination events in plasmids and phages .
    Leucyl aminopeptidase
  • HY-P4161
    KWWCRW

    		DNA/RNA Synthesis Cancer
    KWWCRW is a Holliday linker inhibitory peptide with anticancer activity. KWWCRW inhibits homologous recombination repair (HDR) during DNA repair by binding to the reactive Holliday linker intermediate and preventing its degradation, and inhibits site-specific recombination by bacteriophage in vitro .
    KWWCRW
  • HY-118168
    A 9387

    Galosfen

    		 Others Others
    A9387 is an inhibitor of the Tn3 Resolvase, which promotes site-specific recombination reactions between two directly repeated recombination sites. Several inhibitors have been isolated that inhibit this event. A9387 inhibits the binding of resolvase to the res site .
    A 9387
  • HY-148835
    AzGGK

    		Fluorescent Dye Others
    AzGGK is an unnatural amino acid. AzGGK is site-specifically incorporated into proteins via genetic-code expansion. AzGGK can be used as site-specific probe for ubiquitylation and SUMOylation . AzGGK is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    AzGGK
  • HY-E70371
    Cre recombinase

    		Biochemical Assay Reagents Others
    Cre recombinase is a resolvase derived from the P1 bacteriophage. Cre recombinase catalyzes site-specific recombination between two loxP DNA sequences, converts dimers of P1 chromosome into monomers before cell division. Cre recombinase is utilized in genetic engineering and molecular biology applications .
    Cre recombinase
  • HY-123615
    SPD-2

    		Endogenous Metabolite Cardiovascular Disease Inflammation/Immunology
    SPD-2 is a photo-controlled hydrogen sulfide (H2S) donor that can generate hydrogen sulfide (H2S) upon UVA irradiation (325-385 nm). SPD-2 enables photo-controlled, site-specific H2S release in living cells .
    SPD-2
  • HY-148835A
    AzGGK TFA

    		Fluorescent Dye Others
    AzGGK TFA is an unnatural amino acid. AzGGK TFA is site-specifically incorporated into proteins via genetic-code expansion. AzGGK TFA can be used as a site-specific probe for ubiquitylation and SUMOylation. AzGGK TFA is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups .
    AzGGK TFA
  • HY-D1363
    BDP R6G maleimide

    		Fluorescent Dye Others
    BDP R6G maleimide is a borodipyrromethane fluorophore with absorption and emission wavelengths similar to those of R6G rhodamine. Sulfhydryl labelling is a common protein modification where the cysteine residues in the protein allow more site-specific labelling than the NHS ester of the amine group. BDP R6G maleimide is a thiol reactive dye that reacts with thiol groups to form thioester bonds .
    BDP R6G maleimide
  • HY-130426
    Maleimido-tri(ethylene glycol)-propionic acid

    Mal-PEG3-acid

    		 ADC Linker PROTAC Linkers Cancer
    Maleimido-tri(ethylene glycol)-propionic acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Maleimido-tri(ethylene glycol)-propionic acid is used for the preparation of neolymphostin-based ADC precursors for site-specific cysteine mutant trastuzumab-A114C conjugation . Maleimido-tri(ethylene glycol)-propionic acid also can be used as a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Maleimido-tri(ethylene glycol)-propionic acid
  • HY-151379
    EM127

    		Histone Methyltransferase Cancer
    EM127 (compound 11c) is a SMYD3 covalent inhibitor with high selectivity, high affinity (KD=13 μM) and site-specificity. EM127 effectively inhibits ERK1/2 phosphorylation and reduces transcriptional regulation of SMYD3 target genes. EM127 effectively and prolongedly impairs methyltransferase activity. EM127 can be used in cancer research, particularly in SMYD3 positive tumours .
    EM127
  • HY-P990027
    Izeltabart

    		ADC Antibody Cancer
    Izeltabart is a high-affinity humanized antibody targeting ADAM9. Izeltabart can be used as ADC Antibody for site-specific conjugation with Maytansinoid-based DM21-C (a Drug-Linker Conjugates for ADC), to synthesize IMGC936 (Antibody-Drug Conjugates (ADCs)) with strong anti-cancer activity. DM21-C is composed of Maytansinoid (microtubule inhibitor) and a stable tripeptide linker. IMGC936 exhibits cytotoxicity against ADAM9-positive human tumor cell lines and potent antitumor activity in xenograft tumor models .
    Izeltabart
  • HY-139957
    Mal-amido-PEG8-Val-Ala-PAB-SG3200

    		Drug-Linker Conjugates for ADC Others
    Mal-amido-PEG8-Val-Ala-PAB-SG3200 is a conjugate for antibody-drug conjugate (ADC) (extracted from patent WO2016166300A1) .
    Mal-amido-PEG8-Val-Ala-PAB-SG3200
  • HY-Y0364
    Ethyl 2-chloroacetoacetate

    A 21960

    		 Others Others
    Ethyl 2-chloroacetoacetate (A 21960) is a Tn3 resolvase inhibitor, and inhibit synapse formation between resolvase and two directly repeated res sites .
    Ethyl 2-chloroacetoacetate
  • HY-157140
    HibK

    		Others Others
    HibK is is a new type of histone mark that is widely distributed in histone proteins. HibK as a useful tool can be used for probing post-translational modification by site-specifically incorporate HibK into proteins .
    HibK
  • HY-E70370
    hrv 3c Protease

    		Virus Protease Others
    hrv 3c Protease is a protease originated from human rhinoviruses. hrv 3c Protease recognizes the sequence LEVLFQGP and cleaves precisely between the Q and GP residues. hrv 3c Protease can be used to remove additional tags from the target proteins .
    hrv 3c Protease
  • HY-103700B
    (Rac)-Azide-phenylalanine

    		Amino Acid Derivatives Others
    (Rac)-Azide-phenylalanine is a racemate of Azide-phenylalanine. Azide-phenylalanine is a phenylalanine derivative and a non-natural amino acid. Azide-phenylalanine can be site-specifically incorporated into proteins and used to label proteins . (Rac)-Azide-phenylalanine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    (Rac)-Azide-phenylalanine

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