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Results for "

tau pathology

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Tau Protein (3) Amyloid-β (1) Autophagy (1) Ferroptosis (1)
By Research Areas:	Cardiovascular Disease (1) Inflammation/Immunology (1) Neurological Disease (6)

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Inhibitory Antibodies

Targets Recommended: Tau Protein

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-103157

PD146176 5 Publications Verification NSC168807	Autophagy Ferroptosis	Cardiovascular Disease
PD146176 (NSC168807), a 15-Lipoxygenase (15-LO) inhibitor, inhibits rabbit reticulocyte 15-LO (K_i=197 nM, IC₅₀=0.54 μM). PD146176 reverses cognitive impairment, brain amyloidosis, and tau pathology by stimulating autophagy in aged triple transgenic mice .

HY-101183

THK5351	Tau Protein	Neurological Disease
THK5351 can be radiolabeled and used as a radiotracer for in vivo imaging of *tau* pathology in the brain.

HY-P99163

Tilavonemab ABBV-8E12; C2N-8E12	Tau Protein	Neurological Disease
Tilavonemab (ABBV-8E12) is a humanized anti-tau antibody that targets the extracellular form of pathological *tau* protein aggregates by binding to the N-terminal 25-30 amino acid residues of *tau* protein. Tilavonemab blocks the ability of human and mouse neurons to take up *tau* aggregates, reduces the loss of brain volume, slows the progression of *tau* pathology, and improves cognitive abilities in transgenic mice expressing mutant human *tau*. Tilavonemab is used in Alzheimer's disease research .

HY-114616

PBB3	Others	Neurological Disease
PBB3, a selective PET ligand, recognizes tau pathology in Alzheimer's disease brains, where dystrophic neurites and diffuse neurofibrils are more clearly detected Tangles with calcification .

HY-162566

REM127	Others	Neurological Disease
REM127 is a small molecule compound capable of modulating calcium homeostasis in cells and possesses neuroprotective effects. REM127 can restore the calcium homeostasis imbalance in cellular models caused by pathological accumulation of tau protein. REM127 can efficiently cross the blood-brain barrier, and it has the potential to rescue synaptic and cognitive deficits in Alzheimer's disease animal models, as well as to slow down the progression of amyloid-beta and tau protein pathologies. REM127 can be used for research in neurodegenerative diseases .

HY-100723

THK-523	Amyloid-β	Neurological Disease
THK-523 has demonstrated its high affinity and selectivity for *tau* pathology both in vitro and in vivo. ¹⁸F-THK523 is a potent tau imaging radiotracer.? ¹⁸F-THK523 is a potent in vivo tau imaging ligand for Alzheimer's disease .

HY-162020

SB1617	Tau Protein	Neurological Disease Inflammation/Immunology
SB1617 is a neuroinflammation-modulating agent, and has neuroprotective effect by reducing pathogenic tau levels through microglia-mediated anti-inflammatory activity .

Cat. No.	Product Name

HY-L069

Anti-Alzheimer's Disease Compound Library	1,448 compounds
Alzheimer’s Disease (AD) is a progressive degenerative brain disease which causes mental and physical decline, gradually resulting in death. Despite the significant public health issue that it poses, only few medical treatments have been approved for Alzheimer’s Disease (AD) and these act to control symptoms rather than alter the course of the disease. Discovery of new therapeutic approaches depends on the study of pathology of AD. Recent research findings have led to greater understanding of disease neurobiology in Alzheimer's Disease (AD) and identification of unique targets for drug development. Several important mechanisms have been proposed to explain the underlying pathology of AD, such as Amyloid cascade hypothesis, Tau hypothesis and Cholinergic hypothesis, etc. MCE offers a unique collection of 1,448 compounds with anti-Alzheimer’s Disease activities or targeting the unique targets of AD. MCE Anti-Alzheimer’s Disease Compound Library is a useful tool for exploring the mechanism of AD and discovering new drugs for AD.

Anti-Alzheimer's Disease Compound Library

1,448 compounds

Alzheimer’s Disease (AD) is a progressive degenerative brain disease which causes mental and physical decline, gradually resulting in death. Despite the significant public health issue that it poses, only few medical treatments have been approved for Alzheimer’s Disease (AD) and these act to control symptoms rather than alter the course of the disease. Discovery of new therapeutic approaches depends on the study of pathology of AD. Recent research findings have led to greater understanding of disease neurobiology in Alzheimer's Disease (AD) and identification of unique targets for drug development. Several important mechanisms have been proposed to explain the underlying pathology of AD, such as Amyloid cascade hypothesis, Tau hypothesis and Cholinergic hypothesis, etc.

MCE offers a unique collection of 1,448 compounds with anti-Alzheimer’s Disease activities or targeting the unique targets of AD. MCE Anti-Alzheimer’s Disease Compound Library is a useful tool for exploring the mechanism of AD and discovering new drugs for AD.

Cat. No.	Product Name	Type

HY-101183

THK5351	Indicators
THK5351 can be radiolabeled and used as a radiotracer for in vivo imaging of *tau* pathology in the brain.

Cat. No.	Product Name	Target	Research Area

HY-P99163

Tilavonemab ABBV-8E12; C2N-8E12	Tau Protein	Neurological Disease
Tilavonemab (ABBV-8E12) is a humanized anti-tau antibody that targets the extracellular form of pathological *tau* protein aggregates by binding to the N-terminal 25-30 amino acid residues of *tau* protein. Tilavonemab blocks the ability of human and mouse neurons to take up *tau* aggregates, reduces the loss of brain volume, slows the progression of *tau* pathology, and improves cognitive abilities in transgenic mice expressing mutant human *tau*. Tilavonemab is used in Alzheimer's disease research .

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