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Results for "

unwinding

" in MedChemExpress (MCE) Product Catalog:

8

Inhibitors & Agonists

1

Natural
Products

1

Recombinant Proteins

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-12342
    ML216
    Maximum Cited Publications
    7 Publications Verification

    CID-49852229

    		 DNA/RNA Synthesis Cancer
    ML216 (CID-49852229) is a potent, selective and cell permeable inhibitor of the DNA unwinding activity of BLM helicase with IC50s of 2.98 μM and 0.97 μM for BLM full-length and BLM 636-1298, respectively. ML216 inhibits ssDNA-dependent ATPase activity of BLM with a Ki of 1.76 µM. Antitumor avtivity .
    ML216
  • HY-19639
    E-982
    1 Publications Verification

    		 DNA/RNA Synthesis Others
    E-982 is a steroid used for the on-line screening of the DNA unwinding element binding protein (DUE-B) immobilized protein column .
    E-982
  • HY-108666
    ATPγS tetralithium salt
    1 Publications Verification

    Adenosine-5'-O-(3-thiotriphosphate) tetralithium salt; Adenosine 5'-[γ-thio]triphosphate tetralithium salt

    		 Eukaryotic Initiation Factor (eIF) P2Y Receptor Neurological Disease Metabolic Disease Inflammation/Immunology
    ATPγS (tetralithium salt) is a P2Y11 receptor agonist, an antioxidant and a neuroprotective agent. ATPγS (tetralithium salt) can be used as a substrate for the nucleotide hydrolysis and RNA unwinding activities of eukaryotic translation initiation factor eIF4A. ATPγS (tetralithium salt) is active in ATP hydrolysis .
    ATPγS tetralithium salt
  • HY-E70379
    Tte UvrD Helicase

    		DNA/RNA Synthesis Others
    Tte UvrD Helicase is a thermostable UvrD helicase initially isolated from Thermoanaerobacter tengcongensis. Tte UvrD Helicase can unwind DNA duplexes with 3’ or 5’ single-stranded DNA tails, and DNA substrates with blunt ends .
    Tte UvrD Helicase
  • HY-168933
    KWR095

    		DNA/RNA Synthesis Cancer
    KWR095 is an orally active WRN inhibitor with an IC50 of 0.032 μM for WRN ATPase. KWR095 can impede the duplex unwinding activity of WRN and inhibit the proliferation of tumor cells. KWR095 has anti-tumor activity .
    KWR095
  • HY-118138
    NC-182

    		DNA Alkylator/Crosslinker Cancer
    NC-182 is an anti-tumor agent and DNA intercalator with a preference for B-form DNA. NC-182 can also promote the unwinding of Z-form DNA to B-form. NC-182 has a potent inhibitory effect on multidrug-resistant and sensitive tumors.
    NC-182
  • HY-134361
    ATP-γ-S tetrasodium

    		P2Y Receptor Eukaryotic Initiation Factor (eIF) Neurological Disease Metabolic Disease Inflammation/Immunology
    ATP-γ-S (tetrasodium) is a P2Y11 receptor agonist, an antioxidant and a neuroprotective agent. ATP-γ-S (tetrasodium) can be used as a substrate for the nucleotide hydrolysis and RNA unwinding activities of eukaryotic translation initiation factor eIF4A. ATP-γ-S (tetrasodium) is active in ATP hydrolysis .
    ATP-γ-S tetrasodium
  • HY-130050
    Luzopeptin A

    BBM-928 A

    		 Antibiotic HIV Infection Cancer
    Luzopeptin A (BBM-928 A) is an actinoleukin-like antitumor antibiotic. Luzopeptin A is a bifunctional DNA intercalator which can interact with isolated DNA molecules. Luzopeptin A induces an unwinding-rewinding process of the closed superhelical PM2 DNA. Luzopeptin A is active against HIV-1 and HIV-2 reverse transcriptase with IC50s of 7 nM and 68 nM for HIV-1 RT and HIV-2 RT, respectively .
    Luzopeptin A

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