2. Metabolic Enzyme/Protease
  3. Epoxide Hydrolase
  4. sEH inhibitor-16

sEH inhibitor-16 is a soluble epoxide hydrolase (sEH) inhibitors with an IC50 of 2 nM. sEH inhibitor-16 reduces the inflammatory damage in Cerulein (HY-A0190)-induced acute pancreatitis (AP) in mice and can be used for inflammation/immunology research.

For research use only. We do not sell to patients.

sEH inhibitor-16 Chemical Structure

sEH inhibitor-16 Chemical Structure

CAS No. : 2999636-75-6

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sEH inhibitor-16 Related Antibodies

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Description

sEH inhibitor-16 is a soluble epoxide hydrolase (sEH) inhibitors with an IC50 of 2 nM. sEH inhibitor-16 reduces the inflammatory damage in Cerulein (HY-A0190)-induced acute pancreatitis (AP) in mice and can be used for inflammation/immunology research[1].

IC50 & Target

IC50: 2 nM (sEH)[1]
In Vivo

sEH inhibitor-16 (Compound 28) (10 mg/kg for i.p.) displays protective effects in mouse Cerulein (HY-A0190)-induced acute pancreatitis[1].
sEH inhibitor-16 (Compound 28) (10 mg/kg for i.p.) shows an T1/2 of 7.6 hours and a Cmax of 4.17 ng/mL in CD-1 mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: The murine model of AP induced by repeated Cerulein (HY-A0190) injections [1]
Dosage: 10mg/kg
Administration: Intraperitoneal injection (i.p.)
Result: Displayed aprotective effect evidenced bythereduction ofedema, cell infiltration, and neutrophil numbers.
Animal Model: Male CD-1 mice (Pharmacokinetic assay)[1]
Dosage: 10mg/kg
Administration: Intraperitoneal injection (i.p.)
Result: Pharmacokinetic parameters for sEH inhibitor-16 (Compound 28) in CD-1 mice[1]
Route Dose (mg/kg) T1/2 (h) Tmax (h) Cmax (ng/mL) AUC0-Ꝏ (h•ng/mL)
i.p. 10 7.6 2 4.17 29.9
Molecular Weight

455.63

Formula

C30H37N3O
CAS No.
SMILES

O=C(NC1=CC2=C(N(CC3=CC=C(C(C)C)C=C3)C=C2)C=C1)NCC4(C5)C[C@H](C[C@H]5C6)C[C@H]6C4
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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sEH inhibitor-16 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

sEH inhibitor-162999636-75-6sEH inhibitor16sEH inhibitor 16Epoxide HydrolaseAcute pancreatitis (AP)sEH InhibitorCerulein -Induced APinflammationInhibitorinhibitorinhibit

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