Selepressin acetate  (Synonyms: FE 202158 acetate)

Selepressin (FE 202158) acetate is a selective vasopressin V_1A receptor agonist. Selepressin acetate is a potent vasopressin. Selepressin acetate can be used in the study of septic shock.

Selepressin acetate (100 nM, 48 or 72 h) ameliorates thrombin or VEGF-induced HLMVECs barrier dysfunction^[4].
Selepressin acetate (1-1000 nM, 72 h) prevents the LPS-Induced loss of VE-cadherin and cortical actin in HLMVECs^[4].
Selepressin acetate (100 nM, 48 h) induces the expression of the barrier-protective p53 in HLMVECs^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Selepressin acetate (1 μg/kg/min, left jugular vein infusion for 12 min) increases 38.5% of the mean arterial pressure (MAP) in LPS-induced, fluid-resuscitated rabbit endotoxemia model^[2].
Selepressin acetate (7 pmol/kg/min, 10 μL/min, i.v. infusion) blocks vascular leak in ovine severe sepsis^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1048.28 (free bace)

C₄₆H₇₃N₁₃O₁₁S₂.xC₂H₄O₂

Solid

White to off-white

Room temperature in continental US; may vary elsewhere.

Sealed storage, away from moisture and light, under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)