Semagacestat (Standard) (Synonyms: LY450139 (Standard))

Cat. No.: HY-10009R Purity: ≥98%: FAQs
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Semagacestat (Standard) is the analytical standard of Semagacestat. This product is intended for research and analytical applications. Semagacestat is a γ-secretase inhibitor, inhibits β-amyloid (Aβ42), Aβ38 and Aβ40 with IC50s of 10.9, 12 and 12.1 nM, respectively; also inhibits Notch signaling with IC50 of 14.1 nM. Semagacestat can be used for the research of alzheimer's?disease[1].

For research use only. We do not sell to patients.

Semagacestat (Standard) Chemical Structure

CAS No. : 425386-60-3

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Description	Semagacestat (Standard) is the analytical standard of Semagacestat . This product is intended for research and analytical applications. Semagacestat is a γ-secretase inhibitor, inhibits β-amyloid (Aβ42), Aβ38 and Aβ40 with IC50s of 10.9, 12 and 12.1 nM, respectively; also inhibits Notch signaling with IC50 of 14.1 nM. Semagacestat can be used for the research of alzheimer's?disease[1].
Molecular Weight	361.44
Formula	C₁₉H₂₇N₃O₄
CAS No.	425386-60-3
SMILES	O=C([C@H]1NC([C@@H](NC([C@H](C(C)C)O)=O)C)=O)N(CCC2=C1C=CC=C2)C
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Handling Instructions (2659 KB)

Semagacestat (Standard) Related Classifications

Neurological Disease

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Semagacestat (Standard)425386-60-3LY450139 (Standard)γ-secretaseAmyloid-βNotchGamma secretaseβ-amyloid peptideAβAbetaInhibitorinhibitorinhibit

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Semagacestat (Standard) (Synonyms: LY450139 (Standard))

Product Information

Purity & Documentation

Customer Review

Semagacestat (Standard) Related Classifications

Molarity Calculator

Dilution Calculator