2. Neuronal Signaling NF-κB Metabolic Enzyme/Protease Immunology/Inflammation
  3. Monoamine Oxidase Reactive Oxygen Species
  4. Sembragiline

Sembragiline  (Synonyms: EVT 302; RG1577; RO4602522)

Cat. No.: HY-16731
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Sembragiline (EVT 302) is a potent, selective and reversible monoamine oxidase B (MAO-B) inhibitor. Sembragiline reduces the metabolism of dopamine and other amine neurotransmitters by inhibiting the activity of the MAO-B enzyme, thereby potentially increasing the concentration of these neurotransmitters in the brain. Inhibition of the MAO-B enzyme also reduces the formation of toxic reactive oxygen species (ROS) that play a role in the pathological process of AD. Sembragiline has good oral activity and blood-brain barrier permeability. Sembragiline can be used in studies of AD, especially in patients with AD who show increased MAO-B activity.

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Sembragiline Chemical Structure

Sembragiline Chemical Structure

CAS No. : 676479-06-4

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Sembragiline Related Antibodies

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Description

Sembragiline (EVT 302) is a potent, selective and reversible monoamine oxidase B (MAO-B) inhibitor. Sembragiline reduces the metabolism of dopamine and other amine neurotransmitters by inhibiting the activity of the MAO-B enzyme, thereby potentially increasing the concentration of these neurotransmitters in the brain. Inhibition of the MAO-B enzyme also reduces the formation of toxic reactive oxygen species (ROS) that play a role in the pathological process of AD. Sembragiline has good oral activity and blood-brain barrier permeability. Sembragiline can be used in studies of AD, especially in patients with AD who show increased MAO-B activity[1].

Cellular Effect
Cell Line Type Value Description References
BTI-TN-5B1-4 IC50
3852 nM
Compound: EVT-302; RG1577
Inhibition of human recombinant MAO-A expressed in baculovirus infected BTI-TN-5B1-4 insect cells using p-tyramine as substrate preincubated for 15 mins and measured after 45 mins by resorufin-based fluorescence assay
Inhibition of human recombinant MAO-A expressed in baculovirus infected BTI-TN-5B1-4 insect cells using p-tyramine as substrate preincubated for 15 mins and measured after 45 mins by resorufin-based fluorescence assay
[PMID: 30522087]
BTI-TN-5B1-4 IC50
5.9 nM
Compound: EVT-302; RG1577
Inhibition of human recombinant MAO-B expressed in baculovirus infected BTI-TN-5B1-4 insect cells using p-tyramine as substrate preincubated for 15 mins and measured after 45 mins by resorufin-based fluorescence assay
Inhibition of human recombinant MAO-B expressed in baculovirus infected BTI-TN-5B1-4 insect cells using p-tyramine as substrate preincubated for 15 mins and measured after 45 mins by resorufin-based fluorescence assay
[PMID: 30522087]
Molecular Weight

342.36

Formula

C19H19FN2O3
CAS No.
SMILES

CC(N[C@@H](C1)CN(C2=CC=C(OCC3=CC=CC(F)=C3)C=C2)C1=O)=O
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Sembragiline Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sembragiline676479-06-4EVT 302 RG1577 RO4602522EVT302EVT-302RG1577RG 1577RG-1577RO4602522RO 4602522RO-4602522Monoamine OxidaseReactive Oxygen SpeciesMAOReversible inhibitorneurotransmittersdopamineROSAlzheimer's diseaseMAO-BInhibitorinhibitorinhibit

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