2. GPCR/G Protein Neuronal Signaling
  3. Neurokinin Receptor
  4. Septide

Septide  (Synonyms: (Pyr6,Pro9)-Substance P)

Cat. No.: HY-P2000 Purity: 98.97%
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Septide ((Pyr6,Pro9)-Substance P) is a potent NK1 receptor agonist with a Kd value of 0.55 nM.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Septide Chemical Structure

Septide Chemical Structure

CAS No. : 79775-19-2

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1 mg USD 60 In-stock
5 mg USD 150 In-stock
10 mg USD 240 In-stock
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Based on 1 publication(s) in Google Scholar

Septide Related Antibodies

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Description

Septide ((Pyr6,Pro9)-Substance P) is a potent NK1 receptor agonist with a Kd value of 0.55 nM[1].

IC50 & Target

Kd: 0.55 ± 0.03 nM (NK1 receptor)[1]
In Vitro

Septide increases inositol phosphate levels (4-6-fold) in NK1 receptor expressed CHO cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Septide Related Antibodies
Molecular Weight

763.95

Formula

C39H53N7O7S
CAS No.
Appearance

Solid

Color

White to off-white

Sequence Shortening

Glp-FFPLM-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (130.90 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3090 mL 6.5449 mL 13.0899 mL
5 mM 0.2618 mL 1.3090 mL 2.6180 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.3090 mL 6.5449 mL 13.0899 mL 32.7247 mL
5 mM 0.2618 mL 1.3090 mL 2.6180 mL 6.5449 mL
10 mM 0.1309 mL 0.6545 mL 1.3090 mL 3.2725 mL
15 mM 0.0873 mL 0.4363 mL 0.8727 mL 2.1816 mL
20 mM 0.0654 mL 0.3272 mL 0.6545 mL 1.6362 mL
25 mM 0.0524 mL 0.2618 mL 0.5236 mL 1.3090 mL
30 mM 0.0436 mL 0.2182 mL 0.4363 mL 1.0908 mL
40 mM 0.0327 mL 0.1636 mL 0.3272 mL 0.8181 mL
50 mM 0.0262 mL 0.1309 mL 0.2618 mL 0.6545 mL
60 mM 0.0218 mL 0.1091 mL 0.2182 mL 0.5454 mL
80 mM 0.0164 mL 0.0818 mL 0.1636 mL 0.4091 mL
100 mM 0.0131 mL 0.0654 mL 0.1309 mL 0.3272 mL
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Septide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Septide79775-19-2(Pyr6,Pro9)-Substance PNeurokinin ReceptorNK receptorTachykinin receptorNK1 receptorCHOInhibitorinhibitorinhibit

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