sFTX-3.3

Cat. No.: HY-131942: FAQs
Data Sheet Handling Instructions

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sFTX-3.3 is a Ca²⁺ channel antagonist with IC₅₀s of approximately 0.24 mM and 0.70 mM against P-type and N-type channels.

For research use only. We do not sell to patients.

sFTX-3.3 Chemical Structure

CAS No. : 141997-14-0

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N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

Biological Activity
Purity & Documentation
References
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Description

sFTX-3.3 is a Ca²⁺ channel antagonist with IC₅₀s of approximately 0.24 mM and 0.70 mM against P-type and N-type channels^[1]^[2].

IC₅₀ & Target

P/Q-type calcium channel

0.24 mM (IC₅₀)

N-type calcium channel

0.70 mM (IC₅₀)

In Vitro

sFTX-3.3 (100 μM) reduces the duration of the slow component of presynaptic calcium currents by about 50% of the control and also reduces presynaptic sodium current by approximately 20% of the control. sFTX-3.3 (100 μM) reduces whole-cell sodium current recorded from SK.N.SH cells by approximately 15%^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

287.40

Formula

C₁₂H₂₉N₇O

CAS No.

141997-14-0

SMILES

O=C(NCCCNCCCN)[C@@H](N)CCCNC(N)=N

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Maria Elisa Calcagnotto, et al. An examination of calcium current function on heterotopic neurons in hippocampal slices from rats exposed to methylazoxymethanol. Epilepsia. 2003 Mar;44(3):315-21. [Content Brief]

[2]. T M Norris, et al. Block of high-threshold calcium channels by the synthetic polyamines sFTX-3.3 and FTX-3.3. Mol Pharmacol. 1996 Oct;50(4):939-46. [Content Brief]

[3]. M Fatehi, et al. Polyamine FTX-3.3 and polyamine amide sFTX-3.3 inhibit presynaptic calcium currents and acetylcholine release at mouse motor nerve terminals. Neuropharmacology. 1997 Feb;36(2):185-94. [Content Brief]

sFTX-3.3 Related Classifications

Neurological Disease

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Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

sFTX-3.3141997-14-0Calcium ChannelCa2+ channelsCa channelsInhibitorinhibitorinhibit

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