SGK1-IN-5

Cat. No.: HY-128221: FAQs
Data Sheet Handling Instructions

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SGK1-IN-5 (Compound 1) is an inhibitor for serum and glucocorticoid regulated kinase SGK 1 with an IC₅₀ of 3 nM. SGK1-IN-5 inhibits SGK-1 dependent phosphorylation of GSK3β in U2OS cells with an IC₅₀ of 1.4 μM. SGK1-IN-5 can be used in research about osteoarthritis or rheumatism.

For research use only. We do not sell to patients.

SGK1-IN-5 Chemical Structure

CAS No. : 1426214-51-8

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Biological Activity
Purity & Documentation
References
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Description

Cellular Effect

Cell Line	Type	Value	Description	References
U2OS	IC₅₀	1.4 μM Compound: 1	Inhibition of recombinant human SGK1 (S61 to L431, S422D) expressed in human U20S cells assessed as inhibition of GSK3beta phosphorylation after 6 hrs by fluorescence assay Inhibition of recombinant human SGK1 (S61 to L431, S422D) expressed in human U20S cells assessed as inhibition of GSK3beta phosphorylation after 6 hrs by fluorescence assay	[PMID: 24900601]

Molecular Weight

435.29

Formula

C₁₇H₁₂Cl₂N₆O₂S

CAS No.

1426214-51-8

SMILES

O=S(C1=CC=CC(Cl)=C1Cl)(NC2=CC=C(C3=CN=C4C(NN=C4N)=N3)C=C2)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Nazare M, et al., N-[4-(1H-PYRAZOLO[3,4-b]PYRAZIN-6-YL)-PHENYL]-SULFONAMIDES AND THEIR USE AS PHARMACEUTICALS. US20130072493.

SGK1-IN-5 Related Classifications

Inflammation/Immunology

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SGK1-IN-51426214-51-8SGKSerum-glucocorticoid regulated kinaseSerum and glucocorticoid-regulated kinaseOsteoarthritisrheumatismdegenerative joint disorderInhibitorinhibitorinhibit

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