2. Protein Tyrosine Kinase/RTK
  3. Anaplastic lymphoma kinase (ALK)
  4. SH-E4A-66

SH-E4A-66 is a C2-COUPLr (COvalent Protein Ligator) with carbazole scaffold barring heterogeneous cysteine reactive warheads (acrylamide and chloroacetamide). SH-E4A-66 is capable of coupling with EML4-ALK (EC50=1.5 μM) and inhibiting the activity of EML4-ALK kinase (IC50=2.3 µM).

For research use only. We do not sell to patients.

SH-E4A-66 Chemical Structure

SH-E4A-66 Chemical Structure

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SH-E4A-66 Related Antibodies

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Description

SH-E4A-66 is a C2-COUPLr (COvalent Protein Ligator) with carbazole scaffold barring heterogeneous cysteine reactive warheads (acrylamide and chloroacetamide). SH-E4A-66 is capable of coupling with EML4-ALK (EC50=1.5 μM) and inhibiting the activity of EML4-ALK kinase (IC50=2.3 µM)[1].

IC50 & Target

IC50: 2.3 μM (EML4-ALK)[1].
Molecular Weight

431.87

Formula

C24H18ClN3O3
SMILES

O=C(N1C(C=CC=C2)=C2C3=C1C=CC=C3)C4=CC(NC(C=C)=O)=CC(NC(CCl)=O)=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SH-E4A-66 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SH-E4A-66Anaplastic lymphoma kinase (ALK)Anaplastic lymphoma kinaseALK tyrosine kinase receptorCD246Cluster of differentiation 246carbazole scaffoldEML4-ALKInhibitorinhibitorinhibit

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HY-161910
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