2. Metabolic Enzyme/Protease
  3. Mitochondrial Metabolism
  4. SHS4121705

SHS4121705 is an orally effective mitochondrial uncoupling agent with an IC50 of 4.3 μM in L6 myoblasts. SHS4121705 can be used in the study of non-alcoholic steatohepatitis (NASH).

For research use only. We do not sell to patients.

SHS4121705 Chemical Structure

SHS4121705 Chemical Structure

CAS No. : 2379550-82-8

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SHS4121705 Related Antibodies

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Description

SHS4121705 is an orally effective mitochondrial uncoupling agent with an IC50 of 4.3 μM in L6 myoblasts. SHS4121705 can be used in the study of non-alcoholic steatohepatitis (NASH)[1].

Cellular Effect
Cell Line Type Value Description References
L6 EC50
4.3 μM
Compound: 12i; SHS4121705
Induction of mitochondrial uncoupling in rat L6 cells assessed as increase in oxygen consumption rate incubated for 90 mins by Seahorse XF analyzer based assay
Induction of mitochondrial uncoupling in rat L6 cells assessed as increase in oxygen consumption rate incubated for 90 mins by Seahorse XF analyzer based assay
[PMID: 32392051]
L6 EC50
4.3 μM
Compound: SHS4121705
Induction of mitochondrial uncoupled respiration in rat L6 myoblasts assessed as increase in oxygen consumption rate measured by Agilent Seahorse XF analyzer
Induction of mitochondrial uncoupled respiration in rat L6 myoblasts assessed as increase in oxygen consumption rate measured by Agilent Seahorse XF analyzer
[PMID: 35907607]
MCF7 EC50
4.3 μM
Compound: SHS4121705
Antiproliferative activity against human MCF7 assessed as reduction in cell viability incubated for 24 hrs by MTT assay
Antiproliferative activity against human MCF7 assessed as reduction in cell viability incubated for 24 hrs by MTT assay
[PMID: 33569941]
In Vivo

SHS4121705 (25 mg/kg, orally, for 21 days) decreases liver triglyceride levels and improves liver markers in STAM mouse models[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

313.19

Formula

C11H6F3N5O3
CAS No.
SMILES

O=C1N=C2C(N=C1NC3=CC=C(OC(F)(F)F)C=C3)=NON2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SHS4121705 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SHS41217052379550-82-8SHS 4121705SHS-4121705Mitochondrial MetabolismL6 myoblastsNASHSTAM Mouse ModelInhibitorinhibitorinhibit

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HY-137922
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