2. Natural Products
  3. Plants Terpenoids
  4. Plantaginaceae Diterpenoids
  5. Veronicastrum sibiricum (L.) Pennell
  6. Sibiriquinone A

Sibiriquinone A is a diterpene which can be extracted from Veronicastrum sibiricum. Sibiriquinone A exerts immunosuppressive activity and can be used for relevant researches.

For research use only. We do not sell to patients.

Sibiriquinone A Chemical Structure

Sibiriquinone A Chemical Structure

CAS No. : 723300-08-1

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Based on 1 publication(s) in Google Scholar

Sibiriquinone A Related Antibodies

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Description

Sibiriquinone A is a diterpene which can be extracted from Veronicastrum sibiricum. Sibiriquinone A exerts immunosuppressive activity and can be used for relevant researches[1].

Cellular Effect
Cell Line Type Value Description References
AGS IC50
0.34 μM
Compound: 1, sibiriquinone a
Inhibition of HIF1 activation in human AGS cells assessed as inhibition of hypoxia-induced luciferase expression after 16 hrs by reporter assay
Inhibition of HIF1 activation in human AGS cells assessed as inhibition of hypoxia-induced luciferase expression after 16 hrs by reporter assay
[PMID: 17583950]
AGS IC50
21.2 μM
Compound: 1, sibiriquinone a
Viability of human AGS cells under hypoxic conditions after 24 hrs by MTT assay
Viability of human AGS cells under hypoxic conditions after 24 hrs by MTT assay
[PMID: 17583950]
AGS IC50
35.7 μM
Compound: 1, sibiriquinone a
Viability of human AGS cells under normoxic conditions after 24 hrs by MTT assay
Viability of human AGS cells under normoxic conditions after 24 hrs by MTT assay
[PMID: 17583950]
Hep 3B2 IC50
> 50 μM
Compound: 1, sibiriquinone a
Viability of human Hep3B cells under normoxic conditions after 24 hrs by MTT assay
Viability of human Hep3B cells under normoxic conditions after 24 hrs by MTT assay
[PMID: 17583950]
Hep 3B2 IC50
> 50 μM
Compound: 1, sibiriquinone a
Viability of human Hep3B cells under hypoxic conditions after 24 hrs by MTT assay
Viability of human Hep3B cells under hypoxic conditions after 24 hrs by MTT assay
[PMID: 17583950]
Hep 3B2 IC50
0.28 μM
Compound: 1, sibiriquinone a
Inhibition of HIF1 activation in human Hep3B cells assessed as inhibition of hypoxia-induced luciferase expression after 16 hrs by reporter assay
Inhibition of HIF1 activation in human Hep3B cells assessed as inhibition of hypoxia-induced luciferase expression after 16 hrs by reporter assay
[PMID: 17583950]
Hep 3B2 IC50
3.5 μM
Compound: 1, sibiriquinone a
Inhibition of hypoxia-induced secreted VEGF levels in Hep3B cells after 1 hr by ELISA
Inhibition of hypoxia-induced secreted VEGF levels in Hep3B cells after 1 hr by ELISA
[PMID: 17583950]
In Vitro

Sibiriquinone A (5-80 μM, 72 h) inhibits the lymphocyte transformation in a dose-dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Sibiriquinone A Related Antibodies
Molecular Weight

280.36

Formula

C19H20O2
CAS No.
SMILES

O=C1C=C(C(C)C)C(C2=C1C(C=CCC3(C)C)=C3C=C2)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Sibiriquinone A Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sibiriquinone A723300-08-1OthersditerpeneVeronicastrum sibiricumimmunosuppressiveInhibitorinhibitorinhibit

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