Silperisone hydrochloride  (Synonyms: RGH-5002)

Silperisone hydrochloride is an organosilicone compound similar to tolperisone that has centrally acting muscle relaxant properties. Silperisone (hydrochloride) is a sodium channel protein type 2 alpha channel blocker that blocks sodium and calcium channels in cells, reduces muscle cell excitability and contraction, reduces peripheral tone, and acts as a muscle relaxant and peripheral vascular dilator. Silperisone (hydrochloride) is used to study recurrent painful myoclonus due to spinal cord injury, abnormal hypertonia due to cerebrovascular disease, myotonia symptoms, pyramidal tonia syndrome, multiple sclerosis myospasm, and myelitis^[1][2][3].

301.90

C₁₅H₂₅ClFNSi

140944-30-5

FC1=CC=C(C[Si](C)(CN2CCCCC2)C)C=C1.Cl

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Farkas S, et al. Simple pharmacological test battery to assess efficacy and side effect profile of centrally acting muscle relaxant drugs[J]. Journal of Pharmacological and Toxicological methods, 2005, 52(2): 264-273.  [Content Brief]

  [2]. Kocsis P, et al. Tolperisone-type drugs inhibit spinal reflexes via blockade of voltage-gated sodium and calcium channels[J]. Journal of Pharmacology and Experimental Therapeutics, 2005, 315(3): 1237-1246.  [Content Brief]

  [3]. Farkas S, et al. Silperisone: a centrally acting muscle relaxant[J]. CNS Drug Reviews, 2006, 12(3‐4): 218-235.  [Content Brief]