2. Cell Cycle/DNA Damage Epigenetics
  3. Sirtuin
  4. Sirt2-IN-6

Sirt2-IN-6 (compound 24a) potent and selective inhibitor of SIRT2, with an IC50 of 0.815 μM. Sirt2-IN-6 can be used for the research of cancer.

For research use only. We do not sell to patients.

Sirt2-IN-6 Chemical Structure

Sirt2-IN-6 Chemical Structure

CAS No. : 2243151-81-5

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Sirt2-IN-6 Related Antibodies

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Description

Sirt2-IN-6 (compound 24a) potent and selective inhibitor of SIRT2, with an IC50 of 0.815 μM. Sirt2-IN-6 can be used for the research of cancer[1].

IC50 & Target[1]

SIRT2

0.815 μM (IC50)

Cellular Effect
Cell Line Type Value Description References
NCI-H441 IC50
3.93 μM
Compound: 24a
Antiproliferative activity against human NCI-H441 cells after 72 hrs by MTT assay
Antiproliferative activity against human NCI-H441 cells after 72 hrs by MTT assay
[PMID: 29957526]
Molecular Weight

502.59

Formula

C26H26N6O3S
CAS No.
SMILES

O=C(C1=CN(C)N=C1)NC2=CC=C(C=C2)OCC3=CC(NC(CSC4=NC(C)=CC(C)=N4)=O)=CC=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Sirt2-IN-6 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sirt2-IN-62243151-81-5SirtuinInhibitorinhibitorinhibit

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