2. MAPK/ERK Pathway GPCR/G Protein Stem Cell/Wnt Protein Tyrosine Kinase/RTK
  3. Raf Ras MEK ERK VEGFR Tie c-Fms
  4. SJ-C1044

SJ-C1044 is an orally available pan-RAF inhibitor with immunomodulatory and anti-tumor activities. SJ-C1044 inhibits wild-type BRAF, wild-type CRAF, and BRAF (V600E) with IC50 values ??of 331, 257, and 187 nM, respectively. SJ-C1044 inhibits tumor cell proliferation by inhibiting kras activation and MEK-ERK phosphorylation. In addition, SJ-C1044 also has a certain inhibitory effect on VEGFR2, TIE2, and CSF1R, with IC50 values ??of 100, 23, and 235 nM, respectively. SJ-C1044 improves the tumor immune microenvironment by inhibiting angiogenesis and regulating macrophage function. SJ-C1044 can be used in the study of colorectal cancer.

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SJ-C1044 Chemical Structure

SJ-C1044 Chemical Structure

CAS No. : 2121503-76-0

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SJ-C1044 Related Antibodies

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Tie2

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Description

SJ-C1044 is an orally available pan-RAF inhibitor with immunomodulatory and anti-tumor activities. SJ-C1044 inhibits wild-type BRAF, wild-type CRAF, and BRAF (V600E) with IC50 values ??of 331, 257, and 187 nM, respectively. SJ-C1044 inhibits tumor cell proliferation by inhibiting kras activation and MEK-ERK phosphorylation. In addition, SJ-C1044 also has a certain inhibitory effect on VEGFR2, TIE2, and CSF1R, with IC50 values ??of 100, 23, and 235 nM, respectively. SJ-C1044 improves the tumor immune microenvironment by inhibiting angiogenesis and regulating macrophage function. SJ-C1044 can be used in the study of colorectal cancer[1].

IC50 & Target[1]

VEGFR2

100 nM (IC50)

BRAFWT

331 nM (IC50)

BRafV600E

187 nM (IC50)

CRAF

257 nM (IC50)

Tie2

23 nM (IC50)

CSF1R

235 nM (IC50)

Molecular Weight

561.41

Formula

C25H14F7N7O
CAS No.
SMILES

FC(C(NC(C1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1)=O)=C2)=CC=C2NC3=NC=CC=C3C4=NC=NC5=C4N=CN5
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SJ-C1044 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SJ-C10442121503-76-0RafRasMEKERKVEGFRTiec-FmsRaf kinasesMitogen-activated protein kinase kinaseMAPKKMAP2KExtracellular signal regulated kinasesVascular endothelial growth factor receptorAngiopoietin receptorCSF-1 receptorcolony stimulating factor 1 receptorCSF-1RCSF1RInhibitorsImmunomodulatoryAntiproliferativeTumor MicroenvironmentAngiogenesisMacrophagesInhibitorinhibitorinhibit

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