2. Epigenetics
  3. Epigenetic Reader Domain
  4. SJ1461

SJ1461 is a potent and orally active BET inhibitor. SJ1461 inhibits BRD2 (BD1), and BRD2 (BD2), BRD4 (BD1), and BRD4 (BD2) with IC50 values of 1.6 nM, 0.1 nM, 6.5 nM, and 0.2 nM, respectively.

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SJ1461 Chemical Structure

SJ1461 Chemical Structure

CAS No. : 2924546-70-1

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SJ1461 Related Antibodies

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Description

SJ1461 is a potent and orally active BET inhibitor. SJ1461 inhibits BRD2 (BD1), and BRD2 (BD2), BRD4 (BD1), and BRD4 (BD2) with IC50 values of 1.6 nM, 0.1 nM, 6.5 nM, and 0.2 nM, respectively[1].

IC50 & Target[1]

BRD2 (BD1)

1.6 nM (IC50)

BRD2 (BD2)

0.1 nM (IC50)

BRD4 (BD1)

6.5 nM (IC50)

BRD4 (BD2)

0.2 nM (IC50)

In Vitro

SJ1461 inhibits cancer cells growth of MV4-11, NALM-16, MOLM-13, HDMB03, and D283 cells, with IC50 values of 20 nM, 3.6 nM, 10.2 nM, 6.6 nM, and 56.2 nM, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SJ1461 Related Antibodies
Molecular Weight

484.00

Formula

C21H18ClN7OS2
CAS No.
SMILES

CC1=NN=C2[C@@H](N=C(C3=C(N12)SC(C)=C3C)C4=CC=C(C=C4)Cl)CC(NC5=NN=CS5)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SJ1461 Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SJ14612924546-70-1SJ 1461SJ-1461Epigenetic Reader DomainBETBRD2 (BD1)BRD2 (BD2)BRD4 (BD1)BRD4 (BD2)orally activeInhibitorinhibitorinhibit

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