SK3 Channel-IN-1

Cat. No.: HY-147556: FAQs
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SK3 Channel-IN-1 (compound 7a) is a potent and specific SK3 channel modulator. SK3 Channel-IN-1 has efficient effect on breast cancer MDA-MB-435 cell migration while exhibiting low cytotoxicity in other cell lines. SK3 Channel-IN-1 can modulate ion channels’activity in cancer.

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SK3 Channel-IN-1 Chemical Structure

CAS No. : 2396571-04-1

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Description

IC₅₀ & Target

IC₅₀: 16 μM in CaCo-2^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
Caco-2	IC₅₀	16 μM Compound: 7a	Toxicity in human Caco-2 cells assessed as reduction in cell number after 48 hrs by Hoechst 33342 staining based assay Toxicity in human Caco-2 cells assessed as reduction in cell number after 48 hrs by Hoechst 33342 staining based assay	[PMID: 31753515]
Fibroblast	IC₅₀	> 25 μM Compound: 7a	Toxicity in human skin fibroblasts assessed as reduction in cell number after 48 hrs by Hoechst 33342 staining based assay Toxicity in human skin fibroblasts assessed as reduction in cell number after 48 hrs by Hoechst 33342 staining based assay	[PMID: 31753515]
HCT-116	IC₅₀	> 25 μM Compound: 7a	Toxicity in human HCT-116 cells assessed as reduction in cell number after 48 hrs by Hoechst 33342 staining based assay Toxicity in human HCT-116 cells assessed as reduction in cell number after 48 hrs by Hoechst 33342 staining based assay	[PMID: 31753515]
Huh-7	IC₅₀	> 25 μM Compound: 7a	Toxicity in human Huh-7 cells assessed as reduction in cell number after 48 hrs by Hoechst 33342 staining based assay Toxicity in human Huh-7 cells assessed as reduction in cell number after 48 hrs by Hoechst 33342 staining based assay	[PMID: 31753515]
MCF7	IC₅₀	> 25 μM Compound: 7a	Toxicity in human MCF7 cells assessed as reduction in cell number after 48 hrs by Hoechst 33342 staining based assay Toxicity in human MCF7 cells assessed as reduction in cell number after 48 hrs by Hoechst 33342 staining based assay	[PMID: 31753515]
MDA-MB-231	IC₅₀	> 25 μM Compound: 7a	Toxicity in human MDA-MB-231 cells assessed as reduction in cell number after 48 hrs by Hoechst 33342 staining based assay Toxicity in human MDA-MB-231 cells assessed as reduction in cell number after 48 hrs by Hoechst 33342 staining based assay	[PMID: 31753515]
NCI-H727	IC₅₀	> 25 μM Compound: 7a	Toxicity in human NCI-H727 cells assessed as reduction in cell number after 48 hrs by Hoechst 33342 staining based assay Toxicity in human NCI-H727 cells assessed as reduction in cell number after 48 hrs by Hoechst 33342 staining based assay	[PMID: 31753515]
PC-3	IC₅₀	> 25 μM Compound: 7a	Toxicity in human PC-3 cells assessed as reduction in cell number after 48 hrs by Hoechst 33342 staining based assay Toxicity in human PC-3 cells assessed as reduction in cell number after 48 hrs by Hoechst 33342 staining based assay	[PMID: 31753515]

Molecular Weight

379.66

Formula

C₂₅H₄₉NO

CAS No.

2396571-04-1

SMILES

CCCCCCCCCCCCCCCCC[C@@H](C[C@@H]1C=CCCN1C)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Kouba S, et al. Lipidic synthetic alkaloids as SK3 channel modulators. Synthesis and biological evaluation of 2-substituted tetrahydropyridine derivatives with potential anti-metastatic activity. Eur J Med Chem. 2020;186:111854. [Content Brief]

SK3 Channel-IN-1 Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SK3 Channel-IN-12396571-04-1Potassium ChannelKcsABreast cancerCell migrationIon channelAnticancerMDA-MB-435?cellsInhibitorinhibitorinhibit

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SK3 Channel-IN-1

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