2. Stem Cell/Wnt
  3. Wnt β-catenin
  4. SKL2001 (GMP)

SKL2001 (GMP) is SKL2001 (HY-101085) produced by using GMP guidelines. SKL2001 is an agonist of the Wnt/β-catenin pathway, with anti-cancer activity. SKL2001 stabilizes intracellular β-catenin via disruption of the Axin/β-catenin interaction.

For research use only. We do not sell to patients.

SKL2001 (GMP) Chemical Structure

SKL2001 (GMP) Chemical Structure

CAS No. : 909089-13-0

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SKL2001 (GMP) Related Antibodies

Top Publications Citing Use of Products

45 Publications Citing Use of MCE SKL2001 (GMP)

WB

    SKL2001 (GMP) purchased from MedChemExpress. Usage Cited in: Mol Ther Nucleic Acids. 2020 Jun 27;21:577-591.  [Abstract]

    Western blotting confirmed that β-catenin signaling is activated after GC cells are cultured with SKL2001 (40 μM), accompanied by the enhanced expression of the downstream molecules Cyclin D1, c-Myc, and nuclear β-catenin in BGC-823 cells.

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    Description

    SKL2001 (GMP) is SKL2001 (HY-101085) produced by using GMP guidelines. SKL2001 is an agonist of the Wnt/β-catenin pathway, with anti-cancer activity. SKL2001 stabilizes intracellular β-catenin via disruption of the Axin/β-catenin interaction[1].

    IC50 & Target

    Wnt/β-catenin[1]
    In Vitro

    SKL2001 is an agonist of the Wnt/β-catenin pathway, and also upregulates the expression of Axin2, a downstream target of the Wnt/β-catenin pathway, but shows no effect on NF-κB, p53 reporter activity and GSK-3β activity. SKL2001 causes osteoblast differentiation (20 and 40 μM) and suppresses preadipocyte differentiation (5, 10, and 30 μM) via the activation of the Wnt/β-catenin pathway. SKL2001 (5, 10, and 30 μM) stabilizes intracellular β-catenin in 3T3-L1 cells[1]. SKL2001 (40 μM) significantly inhibits the proliferation of HCT116 spheroids independently of cytotoxicity and the inhibition is reversible; SKL2001 cuases cell cycle arrest in HCT116 spheroids. SKL2001 (40 μM) enhances round-shape spheroid formation and E-cadherin expression[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    SKL2001 (GMP) Related Antibodies
    Molecular Weight

    286.29

    Formula

    C14H14N4O3
    CAS No.
    SMILES

    O=C(C1=NOC(C2=CC=CO2)=C1)NCCCN3C=CN=C3
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
    References
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    SKL2001 (GMP) Related Classifications

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    SKL2001 (GMP)909089-13-0Wntβ-cateninBeta cateninInhibitorinhibitorinhibit

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