2. MAPK/ERK Pathway Stem Cell/Wnt Autophagy
  3. ERK Autophagy
  4. SKLB-D18

SKLB-D18 is a potent and selective inhibitor of ERK1/2 and ERK5, with an IC50 of 38.69, 40.12 and 59.72 nM, respectively. SKLB-D18 is also an autophagy agonist, played a role in mTOR/p70S6K and NCOA4-mediated ferroptosis, which may mitigate multidrug resistance. SKLB-D18 exhibits significantly superior efficacy in vitro and in vivo against triple-negative breast cancer (TNBC).

For research use only. We do not sell to patients.

SKLB-D18 Chemical Structure

SKLB-D18 Chemical Structure

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SKLB-D18 Related Antibodies

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ERK ERK1 ERK2 ERK5 ERK8

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Description

SKLB-D18 is a potent and selective inhibitor of ERK1/2 and ERK5, with an IC50 of 38.69, 40.12 and 59.72 nM, respectively. SKLB-D18 is also an autophagy agonist, played a role in mTOR/p70S6K and NCOA4-mediated ferroptosis, which may mitigate multidrug resistance. SKLB-D18 exhibits significantly superior efficacy in vitro and in vivo against triple-negative breast cancer (TNBC)[1].

Molecular Weight

472.99

Formula

C22H25ClN6O2S
SMILES

CN(C)CC1=CC=CC(NC2=NC(C3=CSC(C(NN4CCOCC4)=O)=C3)=C(Cl)C=N2)=C1
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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SKLB-D18 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SKLB-D18ERKAutophagyExtracellular signal regulated kinasesInhibitorinhibitorinhibit

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