2. Neuronal Signaling
  3. OLIG2
  4. SKOG102

SKOG102 is a potent OLIG2 inhibitor that is directly engaging OLIG2 and interferes with the ability of OLIG2 to bind DNA. SKOG102 can be used for the research of glioblastoma (GBM).

For research use only. We do not sell to patients.

SKOG102 Chemical Structure

SKOG102 Chemical Structure

CAS No. : 21062-28-2

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SKOG102 Related Antibodies

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Description

SKOG102 is a potent OLIG2 inhibitor that is directly engaging OLIG2 and interferes with the ability of OLIG2 to bind DNA. SKOG102 can be used for the research of glioblastoma (GBM)[1].

IC50 & Target

OLIG2[1]
Cellular Effect
Cell Line Type Value Description References
PC-12 IC50
1.1 μM
Compound: 18, TKO-10-20
Inhibition of nicotinic cholinergic receptor in rat PC12 cells assessed as inhibition of nicotine-stimulated [3H]-norepinephrine release after 30 mins by liquid scintillation counting analysis
Inhibition of nicotinic cholinergic receptor in rat PC12 cells assessed as inhibition of nicotine-stimulated [3H]-norepinephrine release after 30 mins by liquid scintillation counting analysis
[PMID: 23916146]
In Vitro

SKOG102 (0.1-5 μM; 72 h) inhibits human GBM4 and GBM8 cells grown as neurospheres, with IC50s of 10.66 and 1.536 μM, respectively[1].
SKOG102 (0.5-5 μM; 12 h) increases p21 RNA levels and decreases OMG RNA levels in GBM4 cells[1].
SKOG102 (5 μM; 20 h) suppresses OLIG2-DNA binding, and decreases the serine phosphorylated OLIG2 and total OLIG2 protein levels in GBM8 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SKOG102 Related Antibodies
In Vivo

SKOG102 (10-20 mg/kg; i.p.) inhibits GBM4 tumor growth in mice[1].
SKOG102 (5 mg/kg; i.p.) accumulates in the tumor even over a relatively brief time period and the plasma and brain concentrations are almost identical at 4 hours after injection in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: NSG mice were inoculated in each flank with GBM4 cells[1]
Dosage: 10, 15, and 20 mg/kg; dissolved in solutol:PEG400:water (20%:40%:40%)
Administration: Intraperitoneal injection; first 2 weeks (from day 33 to 46) 10 mg/kg, third week (from day 47 to 54) 15 mg/kg, fourth week (from 55 to 66) first 3 days 20 mg/kg, 2 days break, then alternate days from day 60 to 66
Result: Significantly attenuated tumor growth.
Molecular Weight

422.35

Formula

C19H25Cl2N7
CAS No.
SMILES

N=C(NC1=NC(C)=CC(NC2CN(CC)CCC2)=N1)NC3=CC=C(Cl)C(Cl)=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SKOG102 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SKOG10221062-28-2SKOG 102SKOG-102OLIG2Oligodendrocyte Transcription Factor 2DNAglioblastomaGBMInhibitorinhibitorinhibit

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