SM-360320 (Synonyms: CL-087)

Cat. No.: HY-125390 Purity: 98.07%: FAQs
Data Sheet SDS COA Handling Instructions

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SM-360320 (CL-087) is a potent, orally active TLR7 agonist. SM-360320 is a immuno-modulator and exerts an antitumor effect. SM-360320 can act in synergy with DNA vaccines leading to an enhanced Th1 antibody response. SM-360320 can inhibit HCV replication in hepatocytes via a type I IFN-independent mechanism in addition to its IFN-mediated activity.

For research use only. We do not sell to patients.

SM-360320 Chemical Structure

CAS No. : 226907-52-4

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 572	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 572	In-stock	Estimated Time of Arrival: December 31
Solid
1 mg	USD 250	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 520	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 800	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 1500	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 2250	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 3200	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

SM-360320 (CL-087) is a potent, orally active TLR7 agonist. SM-360320 is a immuno-modulator and exerts an antitumor effect. SM-360320 can act in synergy with DNA vaccines leading to an enhanced Th1 antibody response^[1]. SM-360320 can inhibit HCV replication in hepatocytes via a type I IFN-independent mechanism in addition to its IFN-mediated activity^[2].

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	EC₅₀	1.17 μM Compound: SM360320	Agonist activity at human TLR7 expressed in HEK293 cells assessed as induction of NFKappaB activity after 24 hrs by SEAP reporter gene assay Agonist activity at human TLR7 expressed in HEK293 cells assessed as induction of NFKappaB activity after 24 hrs by SEAP reporter gene assay	[PMID: 32001135]
HEK293	EC₅₀	399.4 nM Compound: 3	Agonist activity at human TLR7 expressed in HEK293 cells coexpressing pNiFty2-SEAP reporter by reporter gene assay Agonist activity at human TLR7 expressed in HEK293 cells coexpressing pNiFty2-SEAP reporter by reporter gene assay	[PMID: 20232824]
Huh-7	EC₅₀	30 nM Compound: BHMA	Antiviral activity against HCV infected in human Huh7 cells with persistent PFK1389-Luc-Ubi-Neo-NS3-3'/ET replicon after 48 hrs by luminescence based assay Antiviral activity against HCV infected in human Huh7 cells with persistent PFK1389-Luc-Ubi-Neo-NS3-3'/ET replicon after 48 hrs by luminescence based assay	[PMID: 20028817]

Molecular Weight

315.33

Formula

C₁₅H₁₇N₅O₃

CAS No.

226907-52-4

Appearance

Solid

Color

White to off-white

SMILES

COCCOC1=NC(N)=C2C(N(C(N2)=O)CC3=CC=CC=C3)=N1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (396.41 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.1713 mL	15.8564 mL	31.7128 mL
5 mM	0.6343 mL	3.1713 mL	6.3426 mL
10 mM	0.3171 mL	1.5856 mL	3.1713 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.07%

Select Batch:

Data Sheet (271 KB) SDS (251 KB)

COA (248 KB) HNMR (240 KB) LCMS (261 KB)

Handling Instructions (2659 KB)

References

[1]. Dharmapuri S, et al. An oral TLR7 agonist is a potent adjuvant of DNA vaccination in transgenic mouse tumor models. Cancer Gene Ther. 2009;16(5):462-472. [Content Brief]

[2]. Lee J, et al. Activation of anti-hepatitis C virus responses via Toll-like receptor 7. Proc Natl Acad Sci U S A. 2006;103(6):1828-1833. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.1713 mL	15.8564 mL	31.7128 mL	79.2820 mL
	5 mM	0.6343 mL	3.1713 mL	6.3426 mL	15.8564 mL
	10 mM	0.3171 mL	1.5856 mL	3.1713 mL	7.9282 mL
	15 mM	0.2114 mL	1.0571 mL	2.1142 mL	5.2855 mL
	20 mM	0.1586 mL	0.7928 mL	1.5856 mL	3.9641 mL
	25 mM	0.1269 mL	0.6343 mL	1.2685 mL	3.1713 mL
	30 mM	0.1057 mL	0.5285 mL	1.0571 mL	2.6427 mL
	40 mM	0.0793 mL	0.3964 mL	0.7928 mL	1.9821 mL
	50 mM	0.0634 mL	0.3171 mL	0.6343 mL	1.5856 mL
	60 mM	0.0529 mL	0.2643 mL	0.5285 mL	1.3214 mL
	80 mM	0.0396 mL	0.1982 mL	0.3964 mL	0.9910 mL
	100 mM	0.0317 mL	0.1586 mL	0.3171 mL	0.7928 mL

SM-360320 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SM-360320226907-52-4CL-087SM360320SM 360320CL087CL 087Toll-like Receptor (TLR)oralTLR7antitumor effectDNA vaccinesTh1Inhibitorinhibitorinhibit

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SM-360320 (Synonyms: CL-087)

Customer Review

SM-360320 Related Antibodies

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Biological Activity

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References

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Complete Stock Solution Preparation Table

SM-360320 Related Classifications

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