SMO-IN-3

Cat. No.: HY-150567: FAQs
Data Sheet Handling Instructions

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SMO-IN-3 (compound 12a) is a potent smoothened (SMO) inhibitor with an IC₅₀ value of 34.09 nM for hedgehog (Hh) signaling pathway. SMO-IN-3 has antiproliferative activity against human medulloblastoma cell line Daoy. Anticancer activity.

For research use only. We do not sell to patients.

SMO-IN-3 Chemical Structure

CAS No. : 2376914-71-3

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References
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Description

IC₅₀ & Target

IC₅₀: 34.09 nM (Hh)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
A2058	IC₅₀	> 50 μM Compound: 12a	Antiproliferation activity against human A2058 cells incubated for 72 hrs by MTT assay Antiproliferation activity against human A2058 cells incubated for 72 hrs by MTT assay	[PMID: 32063403]
Daoy	IC₅₀	0.48 μM Compound: 12a	Antiproliferative activity against human DaOY cells incubated for 72 hrs by MTT assay Antiproliferative activity against human DaOY cells incubated for 72 hrs by MTT assay	[PMID: 32063403]

In Vitro

SMO-IN-3 (compound 12a) has antiproliferative activity against human medulloblastoma cell line Daoy with an IC₅₀ of 0.48 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

499.50

Formula

C₂₇H₂₅F₄N₃O₂

CAS No.

2376914-71-3

SMILES

O=C(N(C)C1CCN(C(C2=CC=CC=C2NC3=CC=CC=C3)=O)CC1)C4=CC=C(F)C=C4C(F)(F)F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Ji D, et al. Design, synthesis and biological evaluation of anthranilamide derivatives as potent SMO inhibitors. Bioorg Med Chem. 2020 Mar 15;28(6):115354. [Content Brief]

SMO-IN-3 Related Classifications

Molarity Calculator
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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SMO-IN-32376914-71-3SmoHedgehogSmoothenedanticancermedulloblastomaDaoyInhibitorinhibitorinhibit

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