SMO-IN-4

Cat. No.: HY-153499: FAQs
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SMO-IN-4 (Compound 24) is a potent and orally active smoothened antagonist (IC₅₀: 24 nM). SMO-IN-4 has antitumor activity.

For research use only. We do not sell to patients.

SMO-IN-4 Chemical Structure

CAS No. : 1567963-99-8

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Description

SMO-IN-4 (Compound 24) is a potent and orally active smoothened antagonist (IC₅₀: 24 nM). SMO-IN-4 has antitumor activity^[1].

In Vitro

SMO-IN-4 (10 μM) shows minimal inhibition of all CYP isoforms, and also has low inhibition on hERG (IC₅₀ = 38 µM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

SMO-IN-4 (50 mg/kg, daily by oral gavage) leads to regression of subcutaneous tumor in a subcutaneous xenograft model of Ptch1^+/- mouse medulloblastoma^[2].
PK properties of SMO-IN-4 (compound 24)^[2].

Species	Dose (mg/kg)	AUC_0-24h (ng·h/mL)	C_max (ng/mL)	t_1/2 (h)	F%
Mouse	p.o. (10 mg/kg)	4183	4132	1.0	49
Rat	p.o. (10 mg/kg)	5541	2180	2.3	62
Dog	p.o. (5 mg/kg)	7656	1300	5.4	72

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

450.96

Formula

C₂₄H₂₇ClN₆O

CAS No.

1567963-99-8

SMILES

ClC1=CN=C(N2CC3=CN=C(N4CCC(CC4)O)N=C3CC2)C=C1C5=C(C)C=C(C)C=N5

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Lu W, et al. Design, Synthesis, and Structure-Activity Relationship of Tetrahydropyrido[4,3-d]pyrimidine Derivatives as Potent Smoothened Antagonists with in Vivo Activity. ACS Chem Neurosci. 2017 Sep 20;8(9):1980-1994. [Content Brief]

SMO-IN-4 Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SMO-IN-41567963-99-8SmoSmoothenedtumorxenograft modelPtch1medulloblastomaInhibitorinhibitorinhibit

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