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  4. SN-38-CO-DMEDA TFA

SN-38-CO-DMEDA TFA is the intermediate product for synthesizing antibody-conjugated drug LND1035.

For research use only. We do not sell to patients.

SN-38-CO-DMEDA TFA Chemical Structure

SN-38-CO-DMEDA TFA Chemical Structure

CAS No. : 1224601-17-5

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Based on 1 publication(s) in Google Scholar

SN-38-CO-DMEDA TFA Related Antibodies

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Description

SN-38-CO-DMEDA TFA is the intermediate product for synthesizing antibody-conjugated drug LND1035[1].

IC50 & Target

ADC Intermedia
Molecular Weight

620.57

Formula

C29H31F3N4O8
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

CCC1=C2C(C(N3C2)=CC([C@](O)(C(OC4)=O)CC)=C4C3=O)=NC5=CC=C(OC(N(C)CCNC)=O)C=C51.O=C(O)C(F)(F)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (161.14 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6114 mL 8.0571 mL 16.1142 mL
5 mM 0.3223 mL 1.6114 mL 3.2228 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6114 mL 8.0571 mL 16.1142 mL 40.2855 mL
5 mM 0.3223 mL 1.6114 mL 3.2228 mL 8.0571 mL
10 mM 0.1611 mL 0.8057 mL 1.6114 mL 4.0286 mL
15 mM 0.1074 mL 0.5371 mL 1.0743 mL 2.6857 mL
20 mM 0.0806 mL 0.4029 mL 0.8057 mL 2.0143 mL
25 mM 0.0645 mL 0.3223 mL 0.6446 mL 1.6114 mL
30 mM 0.0537 mL 0.2686 mL 0.5371 mL 1.3429 mL
40 mM 0.0403 mL 0.2014 mL 0.4029 mL 1.0071 mL
50 mM 0.0322 mL 0.1611 mL 0.3223 mL 0.8057 mL
60 mM 0.0269 mL 0.1343 mL 0.2686 mL 0.6714 mL
80 mM 0.0201 mL 0.1007 mL 0.2014 mL 0.5036 mL
100 mM 0.0161 mL 0.0806 mL 0.1611 mL 0.4029 mL
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SN-38-CO-DMEDA TFA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SN-38-CO-DMEDA1224601-17-5Othersintermediate productsynthesizingantibody-conjugated drugInhibitorinhibitorinhibit

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