SN23862

Cat. No.: HY-120313: FAQs
Data Sheet Handling Instructions Technical Support

SN23862 is a cancer prodrug with anti-cancer activity, and an analogue of CB-1954 (HY-13543). SN23862 can be used for cancer research.

For research use only. We do not sell to patients.

SN23862 Chemical Structure

CAS No. : 142439-61-0

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Description

SN23862 is a cancer prodrug with anti-cancer activity, and an analogue of CB-1954 (HY-13543). SN23862 can be used for cancer research^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
CHO-AA8	IC₅₀	1450 μM Compound: 1	Aerobic cytotoxic activity was evaluated by the growth inhibition of AA8 (chinese hamster) aerobic cells Aerobic cytotoxic activity was evaluated by the growth inhibition of AA8 (chinese hamster) aerobic cells	[PMID: 9873426]
CHO-AA8	IC₅₀	1600 μM Compound: 2a	Compound was tested for aerobic growth inhibition against AA8 cells after 4 hr of exposure Compound was tested for aerobic growth inhibition against AA8 cells after 4 hr of exposure	[PMID: 8691449]
CHO-AA8	IC₅₀	470 μM Compound: 6	Aerobic cytotoxicity was assessed in a growth inhibition assay using log phase cultures of the chinese hamster ovary fibroblast line AA8 Aerobic cytotoxicity was assessed in a growth inhibition assay using log phase cultures of the chinese hamster ovary fibroblast line AA8	[PMID: 8035424]
CHO-AA8	IC₅₀	470 μM Compound: 20	Growth inhibition of aerobic chinese hamster ovary fibroblast AA8 cell line using an exposure time of 18 hours Growth inhibition of aerobic chinese hamster ovary fibroblast AA8 cell line using an exposure time of 18 hours	[PMID: 1507207]
EMT6	IC₅₀	1.85 μM Compound: 4	Antiproliferative activity against mouse EMT6 NTRpuro cells after 18 hrs Antiproliferative activity against mouse EMT6 NTRpuro cells after 18 hrs	[PMID: 17326614]
EMT6	IC₅₀	442 μM Compound: 4	Antiproliferative activity against mouse wild type EMT6 NTR-ve cells after 18 hrs Antiproliferative activity against mouse wild type EMT6 NTR-ve cells after 18 hrs	[PMID: 17326614]
SK-OV-3	IC₅₀	> 1000 μM Compound: 1	Aerobic cytotoxic activity was evaluated by the growth inhibition of SKOV (human ovarian cancer line) aerobic cells Aerobic cytotoxic activity was evaluated by the growth inhibition of SKOV (human ovarian cancer line) aerobic cells	[PMID: 9873426]
UV4	IC₅₀	108 μM Compound: 20	Growth inhibition of aerobic chinese hamster ovary fibroblast UV4 cells using an exposure time of 18 hours Growth inhibition of aerobic chinese hamster ovary fibroblast UV4 cells using an exposure time of 18 hours	[PMID: 1507207]
UV4	IC₅₀	870 μM Compound: 1	Aerobic cytotoxic activity was evaluated by the growth inhibition of UV4 aerobic cells Aerobic cytotoxic activity was evaluated by the growth inhibition of UV4 aerobic cells	[PMID: 9873426]
V79	IC₅₀	17 μM Compound: 4	Antiproliferative activity against chinese hamster V79 NTRpuro cells after 18 hrs Antiproliferative activity against chinese hamster V79 NTRpuro cells after 18 hrs	[PMID: 17326614]
V79	IC₅₀	490 μM Compound: 4	Antiproliferative activity against chinese hamster wild-type V79 NTR-ve cells after 18 hrs Antiproliferative activity against chinese hamster wild-type V79 NTR-ve cells after 18 hrs	[PMID: 17326614]
WiDr	IC₅₀	703 μM Compound: 4	Antiproliferative activity against human wild type WiDr NTR-ve cells after 18 hrs Antiproliferative activity against human wild type WiDr NTR-ve cells after 18 hrs	[PMID: 17326614]
WiDr	IC₅₀	9.5 μM Compound: 4	Antiproliferative activity against human WiDr NTRneo cells after 18 hrs Antiproliferative activity against human WiDr NTRneo cells after 18 hrs	[PMID: 17326614]

Molecular Weight

351.14

Formula

C₁₁H₁₂Cl₂N₄O₅

CAS No.

142439-61-0

SMILES

O=C(C1=CC(N(CCCl)CCCl)=C(C=C1[N+]([O-])=O)[N+]([O-])=O)N

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Çelik A, et al. An unusually cold active nitroreductase for prodrug activations. Bioorg Med Chem. 2012 Jun 1;20(11):3540-50. [Content Brief]

SN23862 Related Classifications

Molarity Calculator
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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SN23862142439-61-0SN 23862SN-23862Drug DerivativeDrug derivativecancer prodruganti-cancerCB-1954 analogueInhibitorinhibitorinhibit

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SN23862

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SN23862 Related Classifications

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