2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. Calcium Channel
  4. SNX-482

SNX-482, a peptide, is a potent, high affinity, selective and voltage-dependent R-type CaV2.3 channel blocker with an IC50 of 30 nM. SNX-482 has antinociceptive effect.

For research use only. We do not sell to patients.

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SNX-482 Chemical Structure

SNX-482 Chemical Structure

CAS No. : 203460-30-4

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50 μg In-stock

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Based on 1 publication(s) in Google Scholar

SNX-482 Related Antibodies

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N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

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Description

SNX-482, a peptide, is a potent, high affinity, selective and voltage-dependent R-type CaV2.3 channel blocker with an IC50 of 30 nM. SNX-482 has antinociceptive effect[1][2][3].

IC50 & Target

IC50: 30 nM (CaV2.3 channel)[2]
In Vitro

SNX-482 blocks the class E Ca2+ channel with an IC50 of 15-30 nM, using either patch clamp electrophysiology or K+-evoked Ca2+ flux[1].
At low nanomolar concentrations, SNX-482 also blocks a native resistant or R-type Ca2+ current in rat neurohypophyseal nerve terminals, but concentrations of 200-500 nM have no effect on R-type Ca2+ currents in several types of rat central neurons[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SNX-482 Related Antibodies
In Vivo

SNX-482 (0.5-4 μg/5 0μL; applied directly onto the spinal cord; 14-17 days post-operation) in the spinal nerve ligation (SNL) rat model dose - dependently inhibits nociceptive C-fiber and Aδ-fiber-mediated neuronal responses, and the responses to non-noxious mechanical and thermal stimuli are more sensitive in SNL rats than in sham - operated rats[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats (initially weighing 130-150 g) + Spinal nerve ligation[3]
Dosage: 0.5 μg/50 μL, 1.5 μg/50 μL, 4 μg/50 μL
Administration: Applied directly onto the spinal cord, 14-17 days post-operation
Result: Exerted a significant dose-related inhibitory effect on C-fiber evoked responses, Aδ-fiber responses, post-discharge and input measurements.
Inhibited the "wind-up" of neurons.
Molecular Weight

4495.00

Formula

C192H274N52O60S7
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Gly-Val-Asp-Lys-Ala-Gly-Cys-Arg-Tyr-Met-Phe-Gly-Gly-Cys-Ser-Val-Asn-Asp-Asp-Cys-Cys-Pro-Arg-Leu-Gly-Cys-His-Ser-Leu-Phe-Ser-Tyr-Cys-Ala-Trp-Asp-Leu-Thr-Phe-Ser-Asp (Disulfide bridge:Cys7-Cys21;Cys14-Cys26;Cys20-Cys33)
Sequence Shortening

GVDKAGCRYMFGGCSVNDDCCPRLGCHSLFSYCAWDLTFSD (Disulfide bridge:Cys7-Cys21;Cys14-Cys26;Cys20-Cys33)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 0.5 mg/mL (0.11 mM; Need ultrasonic and warming)

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This equation is commonly abbreviated as: C1V1 = C2V2

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Purity & Documentation

Purity: ≥99.0%

SDS (252 KB)

COA (281 KB)

Handling Instructions (2659 KB)
References
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SNX-482 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SNX-482203460-30-4SNX482SNX 482Calcium ChannelCa2+ channelsCa channelsR-typepeptidyltoxinCaV2.3voltage-dependentantinociceptiveInhibitorinhibitorinhibit

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