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  4. SOD1-Derlin-1 inhibitor-1

SOD1-Derlin-1 inhibitor-1 (compound 56-20) is an inhibitor of SOD1-Derlin-1 interaction. SOD1-Derlin-1 inhibitor-1 inhibits SOD1G93A-Derlin-1 complex with an IC50 value of 7.11 μM. SOD1-Derlin-1 inhibitor-1 can be used for the research of amyotrophic lateral sclerosis.

For research use only. We do not sell to patients.

SOD1-Derlin-1 inhibitor-1 Chemical Structure

SOD1-Derlin-1 inhibitor-1 Chemical Structure

CAS No. : 840461-03-2

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Based on 1 publication(s) in Google Scholar

SOD1-Derlin-1 inhibitor-1 Related Antibodies

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Description

SOD1-Derlin-1 inhibitor-1 (compound 56-20) is an inhibitor of SOD1-Derlin-1 interaction. SOD1-Derlin-1 inhibitor-1 inhibits SOD1G93A-Derlin-1 complex with an IC50 value of 7.11 μM. SOD1-Derlin-1 inhibitor-1 can be used for the research of amyotrophic lateral sclerosis[1].

IC50 & Target

IC50: 7.11 μM (SOD1G93A-Derlin-1 complex)[1]
In Vitro

SOD1-Derlin-1 inhibitor-1 (50 μM; 16 h) inhibits SOD1G93A-Derlin-1 complex with an IC50 value of 7.11 μM[1].
SOD1-Derlin-1 inhibitor-1 (250 nM; 6 h) interacts with SOD1G93A with a Kd value of 81.1 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SOD1-Derlin-1 inhibitor-1 Related Antibodies
Molecular Weight

504.20

Formula

C19H12Br2N4OS
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

NC(C1=CC=C(C2=CN=CC=C2)N=C1S3)=C3C(NC(C=CC(Br)=C4)=C4Br)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 2.7 mg/mL (5.36 mM; ultrasonic and warming and adjust pH to 4 with HCl and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9833 mL 9.9167 mL 19.8334 mL
5 mM 0.3967 mL 1.9833 mL 3.9667 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9833 mL 9.9167 mL 19.8334 mL 49.5835 mL
5 mM 0.3967 mL 1.9833 mL 3.9667 mL 9.9167 mL
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SOD1-Derlin-1 inhibitor-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SOD1-Derlin-1 inhibitor-1840461-03-2Otherssmall-moleculemouse modelAmyotrophic lateral sclerosisneurodegenerative disorderdrug targetALSInhibitorinhibitorinhibit

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