2. Apoptosis
  3. Apoptosis
  4. Sodium tetradecyl sulfate

Sodium tetradecyl sulfate (Tergitol 4) is a novel scleroembolic agent and an apoptosis inducer. Sodium tetradecyl sulfate can be used for research on varicose veins and vascular malformation diseases.

For research use only. We do not sell to patients.

Sodium tetradecyl sulfate Chemical Structure

Sodium tetradecyl sulfate Chemical Structure

CAS No. : 139-88-8

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Based on 1 publication(s) in Google Scholar

Sodium tetradecyl sulfate Related Antibodies

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Description

Sodium tetradecyl sulfate (Tergitol 4) is a novel scleroembolic agent and an apoptosis inducer. Sodium tetradecyl sulfate can be used for research on varicose veins and vascular malformation diseases[1][2][3].
In Vitro

Sodium tetradecyl sulfate induces endothelial activation and release of endothelial particles in human umbilical vein endothelial cells (HUVEC)[1].
Sodium tetradecyl sulfate can increase the expression of activation markers CD54 and CD62e in human umbilical vein endothelial cells (HUVEC), promoting HUVEC cell activation[1].
Sodium tetradecyl sulfate inhibits proliferation and induces apoptosis in mouse endothelial tumor (EOMA) cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Sodium tetradecyl sulfate Related Antibodies

Cell Proliferation Assay[1].

Cell Line: EOMA cell
Concentration: 0.1%
Incubation Time: 6 days
Result: Inhibited cell proliferation.

Apoptosis Analysis[1].

Cell Line: EOMA cell
Concentration: 0-0.15%
Incubation Time: 15 min
Result: Increased the percentage of apoptotic cells.
In Vivo

Sodium tetradecyl sulfate (5 mL CH–STS; Intratumoral injection) can reduce type I leakage in bilateral iliac aneurysm models after forming gel (CH-STS) with chitosan[2].
Sodium tetradecyl sulfate (0.3 mL 1% STS; 30 days; i.v.) induces muscle inflammatory response in rats and has a vein blocking effect in the femoral vein[3].
Sodium tetradecyl sulfate (0.5 mL 1% STS; s.c.) can cause exudative skin necrosis in rats[4].
Sodium tetradecyl sulfate (0.2 mL of liquid STS 1% or 0.2 mL STS 1% sclerosing foam; i.v.) promotes the release of endothelin in rats and may lead to vascular spasm and cause neurological disorders[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: A bilateral iliac EVAR model with a type I endoleak[2].
Dosage: 5 mL Chitosan–Sodium Tetradecyl Sulfate Hydrogel (CH–STS)
Administration: Intratumoral injection
Result: Reduced internal leakage and tended to adhere to SG rather than arterial wall.
Animal Model: Male and female Sprague-Dawley rats, weighing 310 ± 24 g [3].
Dosage: 0.3 mL 1% STS
Administration: Intravenous injection (i.v.); once daily; 30 days
Result: Produced a solid occlusion of the vein in a significant number of cases.
Animal Model: Rat[5].
Dosage: 0.2 mL of liquid STS 1% or 0.2 mL STS 1% sclerosing foam
Administration: Intravenous injection (i.v.)
Result: Increased ET-1 levels at 1 minute and 5 minutes.
Clinical Trial
Molecular Weight

316.43

Formula

C14H29NaO4S
CAS No.
Appearance

Liquid (Density: 1.06 g/cm3)

Color

Colorless to light yellow

SMILES

O=S(OC(CC(C)C)CCC(CCCC)CC)(O[Na])=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 62.5 mg/mL (197.52 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1603 mL 15.8013 mL 31.6026 mL
5 mM 0.6321 mL 3.1603 mL 6.3205 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

SDS (476 KB)

COA (245 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 3.1603 mL 15.8013 mL 31.6026 mL 79.0064 mL
5 mM 0.6321 mL 3.1603 mL 6.3205 mL 15.8013 mL
10 mM 0.3160 mL 1.5801 mL 3.1603 mL 7.9006 mL
15 mM 0.2107 mL 1.0534 mL 2.1068 mL 5.2671 mL
20 mM 0.1580 mL 0.7901 mL 1.5801 mL 3.9503 mL
25 mM 0.1264 mL 0.6321 mL 1.2641 mL 3.1603 mL
30 mM 0.1053 mL 0.5267 mL 1.0534 mL 2.6335 mL
40 mM 0.0790 mL 0.3950 mL 0.7901 mL 1.9752 mL
50 mM 0.0632 mL 0.3160 mL 0.6321 mL 1.5801 mL
60 mM 0.0527 mL 0.2634 mL 0.5267 mL 1.3168 mL
80 mM 0.0395 mL 0.1975 mL 0.3950 mL 0.9876 mL
100 mM 0.0316 mL 0.1580 mL 0.3160 mL 0.7901 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Sodium tetradecyl sulfate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sodium tetradecyl139-88-8Tergitol 4Tergitol4Tergitol-4Apoptosisvenous obstructionvaricosityhemangiomaInhibitorinhibitorinhibit

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